{
  "abstract": "Cervical cancer is strongly associated with persistent infection by high-risk human papillomavirus (HPV) and continues to pose a major global health burden in recent times. Oncolytic virotherapy has emerged as a promising targeted strategy that selectively eliminates cancer cells while simultaneously activating host immune responses. In this study, a deterministic mathematical model is developed to investigate the dynamics of HPV-induced cervical cancer under oncolytic virotherapy, both as a standalone intervention and in combination with chemotherapy. The model captures the interactions among HPV-infected epithelial cells, cancer cells, oncolytic virus–infected cancer cells, free viral particles, and virus-specific cytotoxic T-lymphocytes. Fundamental qualitative properties of the system are established, and threshold conditions governing oncolytic virus persistence are identified. To elucidate the relative influence of biological and therapeutic parameters, a comprehensive global sensitivity analysis is performed using the extended Fourier amplitude sensitivity test (eFAST) and partial rank correlation coefficients. This analysis reveals key mechanisms regulating cancer cell dynamics and highlights parameters that critically shape treatment outcomes. An optimal control framework is further employed to assess time-dependent therapeutic strategies, providing insight into effective scheduling of virotherapy and chemotherapy while balancing treatment cost. Furthermore, numerical simulation-based evidences justify the analytical findings obtained in the study and demonstrate the comparative advantages of the combined strategy.",
  "abstract_shown": true,
  "affiliations": [
    "School of Mathematics and Statistics, Beijing Technology and Business University, Beijing, P. R. China",
    "Department of Mathematics, Centre for Mathematical Biology and Ecology, Jadavpur University, Kolkata, West Bengal, India",
    "Department of Mathematics, K. L. S. College, Magadh University, Nawada, Bodh Gaya, Bihar, India"
  ],
  "article_type": "Research Article",
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Salil Ghosh"
    },
    {
      "affs": [
        1
      ],
      "name": "Amit Kumar Bag"
    },
    {
      "affs": [
        2
      ],
      "name": "Satyajit Mukherjee"
    },
    {
      "name": "Xianbing Cao"
    },
    {
      "name": "Amarnath Chatterjee"
    },
    {
      "name": "Priti Kumar Roy"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/939d01zxxna94.bib",
  "cited_by": 0,
  "doi": "10.1371/journal.pone.0342672",
  "fulltext_url": null,
  "id": "939d01zxxna94",
  "issns": [
    "1932-6203"
  ],
  "landing_url": "https://doi.org/10.1371/journal.pone.0342672",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2611|Mathematical Biology Tumor Growth"
    ],
    [
      "plos",
      "/Biology and life sciences/Anatomy/Biological tissue/Epithelium/Epithelial cells"
    ],
    [
      "plos",
      "/Biology and life sciences/Cell biology/Cellular types/Animal cells/Epithelial cells"
    ],
    [
      "plos",
      "/Biology and life sciences/Microbiology/Virology/Viral structure/Virions"
    ],
    [
      "plos",
      "/Medicine and health sciences/Anatomy/Biological tissue/Epithelium/Epithelial cells"
    ],
    [
      "plos",
      "/Medicine and health sciences/Clinical medicine/Clinical oncology/Cancer chemotherapy"
    ],
    [
      "plos",
      "/Medicine and health sciences/Medical conditions/Infectious diseases/Sexually transmitted diseases/Human papillomavirus infection"
    ],
    [
      "plos",
      "/Medicine and health sciences/Medical conditions/Infectious diseases/Viral diseases/Human papillomavirus infection"
    ],
    [
      "plos",
      "/Medicine and health sciences/Oncology/Cancer treatment"
    ],
    [
      "plos",
      "/Medicine and health sciences/Oncology/Cancer treatment/Cancer chemotherapy"
    ],
    [
      "plos",
      "/Medicine and health sciences/Oncology/Cancer treatment/Oncolytic viruses"
    ],
    [
      "plos",
      "/Medicine and health sciences/Oncology/Cancers and neoplasms"
    ],
    [
      "plos",
      "/Medicine and health sciences/Oncology/Cancers and neoplasms/Gynecological tumors/Cervical cancer"
    ],
    [
      "plos",
      "/Medicine and health sciences/Oncology/Clinical oncology/Cancer chemotherapy"
    ],
    [
      "plos",
      "/Medicine and health sciences/Pharmaceutics/Drug therapy/Chemotherapy/Cancer chemotherapy"
    ],
    [
      "plos",
      "/Medicine and health sciences/Urology/Genitourinary infections/Human papillomavirus infection"
    ]
  ],
  "openalex": "W7213900537",
  "pdf_url": "https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0342672&type=printable",
  "pmcid": null,
  "pmid": null,
  "published": "2026-09-21",
  "publisher": "Public Library of Science",
  "ris": "https://research.draconitic.com/paper/939d01zxxna94.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:43Z",
      "native_id": "10.1371/journal.pone.0342672",
      "source": "plos",
      "url": "https://doi.org/10.1371/journal.pone.0342672"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "plos:oncology",
      "subfield": "oncology"
    }
  ],
  "title": "A quantitative treatment assessment for optimizing combined virotherapy-chemotherapy regimens against HPV-induced cervical cancer",
  "title_text": "A quantitative treatment assessment for optimizing combined virotherapy-chemotherapy regimens against HPV-induced cervical cancer",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:43Z",
  "url": "https://research.draconitic.com/paper/939d01zxxna94",
  "venue": "PLOS One",
  "versions": []
}