{
  "abstract": "The human gut microbiota has been explored for the last two decades and studies have uncovered its major role in the degradation of complex glycans from the diet as well as the host tissues. Strikingly, until very recently, no similar investigation has been carried out on the human oral cavity microbiota, which is increasingly recognized has an important parameter in gastrointestinal health. Prevotellaceae are an important and under-investigated family of bacteria in both the gut and the oral cavity microbiota. The oral cavity is particularly rich in glycosaminoglycans which could provide an abundant carbon source for the inhabiting microorganisms, and play a significant role in host-pathogen interactions. Hence, we analyzed Polysaccharide Utilization Loci in oral microbiota species and we identified a glycosaminoglycan-degrading Polysaccharide Utilization Locus in Segatella oris. We produced and characterized the four enzymes, confirmed their ability to degrade glycosaminoglycans, and we focused our efforts on the biochemical and structural characterization of the first reported Prevotellaceae endosulfatase.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": "New results",
  "arxiv": null,
  "author_total": 13,
  "authors": [
    {
      "name": "Abel Cousin"
    },
    {
      "name": "Yara Awad"
    },
    {
      "name": "Rebecca-Joe Boustany"
    },
    {
      "name": "Rosa Lorizolla Cordeiro"
    },
    {
      "name": "Melanie Friedel-Arboleas"
    },
    {
      "name": "Sophie Drouillard"
    },
    {
      "name": "Melanie Loiodice"
    },
    {
      "name": "Laurine Buon"
    },
    {
      "name": "Chrystel Lopin-Bon"
    },
    {
      "name": "Rebekka Wild"
    },
    {
      "name": "William Helbert"
    },
    {
      "name": "Romain Vives"
    },
    {
      "name": "Marie Couturier"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/93apajahs68s4.bib",
  "cited_by": 0,
  "doi": "10.64898/2026.10.07.757250",
  "fulltext_url": "https://www.biorxiv.org/content/10.64898/2026.10.07.757250v1.full",
  "id": "93apajahs68s4",
  "issns": [],
  "landing_url": "https://hal.science/hal-05793575v1",
  "language": "en",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "biorxiv",
      "biochemistry"
    ],
    [
      "hal",
      "0.sdv"
    ],
    [
      "openalex",
      "3506|Oral microbiology and periodontitis research"
    ]
  ],
  "openalex": "W7221118632",
  "pdf_url": "https://www.biorxiv.org/content/10.64898/2026.10.07.757250v1.full.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-07",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/93apajahs68s4.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:54Z",
      "native_id": "hal-05793575",
      "source": "hal",
      "url": "https://hal.science/hal-05793575v1"
    },
    {
      "first_seen": "2026-10-30T12:26:52Z",
      "native_id": "10.64898/2026.10.07.757250",
      "source": "biorxiv",
      "url": "https://www.biorxiv.org/content/10.64898/2026.10.07.757250v1"
    }
  ],
  "subjects": [
    {
      "field": "biochemistry",
      "origin": "biorxiv:biochemistry",
      "subfield": "general"
    },
    {
      "field": "biology",
      "origin": "hal:0.sdv",
      "subfield": "general"
    }
  ],
  "title": "A glycosaminoglycan degrading Polysaccharide Utilization Locus in the oral microbiota species Segatella oris",
  "title_text": "A glycosaminoglycan degrading Polysaccharide Utilization Locus in the oral microbiota species Segatella oris",
  "type": "preprint",
  "updated_at": "2026-10-30T12:26:52Z",
  "url": "https://research.draconitic.com/paper/93apajahs68s4",
  "venue": "HAL",
  "versions": []
}