{ "abstract": "Purpose: Estimated pulse wave velocity (ePWV) is a surrogate of arterial stiffness that may influence stroke outcomes and potentially affect collateral circulation. We examined the association of ePWV with collateral status and 3-month functional outcome after successful endovascular thrombectomy and explored the contribution of collateral status to this relationship across blood pressure (BP) management strategies.\n\nMaterials and Methods: In this secondary analysis of the Outcome in Patients Treated With Intra-Arterial Thrombectomy–Optimal Blood Pressure Control trial, 285 patients were analyzed. Collateral status was assessed using the Tan scale (poor, 0–1; good, 2–3). Poor functional outcome was defined as 3-month modified Rankin Scale score of 3–6. Multivariable logistic and mediation analyses were performed to evaluate the association between ePWV and functional outcomes and to explore direct and indirect pathways.\n\nResults: A total of 285 patients were included (mean age, 73.3±11.3 years; 40.4% women). Each 1 m/s increase in ePWV was associated with poor collaterals (adjusted odds ratio [OR] 1.276, 95% confidence interval [CI] 1.083–1.503) and poor functional outcome (adjusted OR 1.338, 95% CI 1.121–1.597). In mediation analyses, collateral status accounted for only a small proportion of the association between ePWV and poor functional outcome (indirect effect: adjusted β 0.022, 95% CI 0.001–0.053), whereas the direct effect remained significant (adjusted β 0.237, 95% CI 0.115–0.359). Neither the direct effect of ePWV on functional outcome nor the indirect effect through collateral status differed according to BP management strategy.\n\nConclusion: Higher ePWV was associated with poor collateral status and unfavorable functional outcome after successful reperfusion. Collateral status accounted for only a small proportion of the observed association between ePWV and functional outcome.", "abstract_shown": true, "affiliations": [ "Department of Neurology, Yonsei University College of Medicine, Seoul, Korea", "Integrative Research Center for Cerebrovascular and Cardiovascular Diseases, Yonsei University College of Medicine, Seoul, Korea", "Department of Neurology, Kyungpook National University Chilgok Hospital, School of Medicine, Kyungpook National University, Daegu, Korea", "Department of Neurology, Keimyung University Dongsan Hospital, Keimyung University School of Medicine, Daegu, Korea", "Department of Neurology, Seoul Medical Center, Seoul, Korea", "Department of Neurology, Kyung Hee University Hospital at Gangdong, Seoul, Korea", "Department of Radiology, Yonsei University College of Medicine, Seoul, Korea", "Department of Neurology, Korea University Anam Hospital, Korea University College of Medicine, Seoul, Korea", "Department of Neurology, Chosun University School of Medicine, Gwangju, Korea", "Department of Neurology, Ewha Womans University Seoul Hospital, Ewha Womans University College of Medicine, Seoul, Korea", "Graduate Program in System Health Science and Engineering, Ewha Womans University, Seoul, Korea", "Department of Neurology, Ewha Womans University Mokdong Hospital, Ewha Womans University College of Medicine, Seoul, Korea", "Department of Neurology, National Health Insurance Service Ilsan Hospital, Goyang, Korea", "Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea", "Department of Neurology, Dong-A University Hospital, Busan, Korea", "Department of Neurology, Busan Paik Hospital, Inje University College of Medicine, Busan, Korea", "Department of Neurology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea", "Department of Neurology, Pusan National University School of Medicine, Busan, Korea", "Department of Neurology, Gachon University Gil Medical Center, Incheon, Korea", "Department of Neurology, Yongin Severance Hospital, Yonsei University College of Medicine, Yongin, Korea", "Department of Neurology, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea", "Department of Neurology, Kyungpook National University Hospital, School of Medicine, Kyungpook National University, Daegu, Korea", "Department of Neurology, Korea University Guro Hospital, Korea University College of Medicine, Seoul, Korea", "Department of Neurology, Daejeon Eulji Medical Center, Eulji University School of Medicine, Daejeon, Korea", "Department of Health Promotion, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea", "Cardiovascular Research Institute, Yonsei University College of Medicine, Seoul, Korea", "Department of Research Affairs, Biostatistics Collaboration Unit, Yonsei University College of Medicine, Seoul, Korea", "Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea", "Department of Neurology, CHA Bundang Medical Center, CHA University School of Medicine, Seongnam, Korea" ], "article_type": "research article", "arxiv": null, "author_total": 46, "authors": [ { "affs": [ 0, 1 ], "name": "Minho Han", "orcid": "0000-0003-2951-0963" }, { "affs": [ 1 ], "name": "Eunjeong Park", "orcid": "0000-0003-2257-3478" }, { "affs": [ 0 ], "name": "Jae Wook Jung", "orcid": "0000-0002-9219-8522" }, { "affs": [ 0 ], "name": "Hyungwoo Lee", "orcid": "0000-0002-3111-3476" }, { "affs": [ 0 ], "name": "JoonNyung Heo", "orcid": "0000-0001-6287-6348" }, { "affs": [ 0 ], "name": "Young Dae Kim", "orcid": "0000-0001-5750-2616" }, { "affs": [ 0 ], "name": "Haram Joo", "orcid": "0000-0002-3297-1288" }, { "affs": [ 2 ], "name": "Kwang Hyun Kim", "orcid": "0009-0006-1436-0009" }, { "affs": [ 3 ], "name": "Jaeseob Yun", "orcid": "0000-0002-8884-4114" }, { "affs": [ 4 ], "name": "Jin Kyo Choi", "orcid": "0000-0002-2599-4385" }, { "affs": [ 5 ], "name": "Il Hyung Lee", "orcid": "0000-0002-7921-580X" }, { "affs": [ 6 ], "name": "Byung Moon Kim", "orcid": "0000-0001-8593-6841" }, { "affs": [ 6 ], "name": "Dong Joon Kim", "orcid": "0000-0002-7035-087X" }, { "affs": [ 6 ], "name": "Na Young Shin", "orcid": "0000-0003-1157-6366" }, { "affs": [ 7 ], "name": "Bang-Hoon Cho", "orcid": "0000-0003-1730-4345" }, { "affs": [ 8 ], "name": "Seong Hwan Ahn", "orcid": "0000-0002-4778-491X" }, { "affs": [ 3 ], "name": "Hyungjong Park", "orcid": "0000-0002-6112-2939" }, { "affs": [ 3 ], "name": "Sung-Il Sohn", "orcid": "0000-0002-6900-1242" }, { "affs": [ 3 ], "name": "Jeong-Ho Hong", "orcid": "0000-0002-8235-9855" }, { "affs": [ 9, 10 ], "name": "Tae-Jin Song", "orcid": "0000-0002-9937-762X" }, { "affs": [ 11 ], "name": "Yoonkyung Chang", "orcid": "0000-0002-0345-2278" }, { "affs": [ 12 ], "name": "Gyu Sik Kim", "orcid": "0000-0002-9185-0857" }, { "affs": [ 12 ], "name": "Kwon-Duk Seo", "orcid": "0000-0003-3154-8864" }, { "affs": [ 12 ], "name": "Kijeong Lee", "orcid": "0000-0001-6459-2365" }, { "affs": [ 13 ], "name": "Jun Young Chang", "orcid": "0000-0003-4880-9258" }, { "affs": [ 14 ], "name": "Jung Hwa Seo", "orcid": "0000-0003-0207-2772" }, { "affs": [ 15 ], "name": "Sukyoon Lee", "orcid": "0000-0002-5551-0273" }, { "affs": [ 16 ], "name": "Jang-Hyun Baek", "orcid": "0000-0002-6733-0683" }, { "affs": [ 17 ], "name": "Han-Jin Cho", "orcid": "0000-0001-7152-9225" }, { "affs": [ 18 ], "name": "Dong Hoon Shin", "orcid": "0000-0002-1103-1983" }, { "affs": [ 19 ], "name": "Jinkwon Kim", "orcid": "0000-0003-0156-9736" }, { "affs": [ 19 ], "name": "Joonsang Yoo", "orcid": "0000-0003-1169-6798" }, { "affs": [ 19 ], "name": "Minyoul Baik", "orcid": "0000-0002-6582-0953" }, { "affs": [ 20 ], "name": "Yo Han Jung", "orcid": "0000-0002-3048-4718" }, { "affs": [ 21 ], "name": "Yang-Ha Hwang", "orcid": "0000-0002-6665-7481" }, { "affs": [ 22 ], "name": "Chi Kyung Kim", "orcid": "0000-0002-0423-7297" }, { "affs": [ 23 ], "name": "Jae Guk Kim", "orcid": "0000-0003-1418-0033" }, { "affs": [ 24 ], "name": "Chan Joo Lee", "orcid": "0000-0002-8756-409X" }, { "affs": [ 24, 25 ], "name": "Sungha Park", "orcid": "0000-0001-5362-478X" }, { "affs": [ 26 ], "name": "Soyoung Jeon", "orcid": "0000-0002-9916-1917" }, { "affs": [ 26 ], "name": "Hye Sun Lee", "orcid": "0000-0001-6328-6948" }, { "affs": [ 13 ], "name": "Sun U Kwon", "orcid": "0000-0003-2247-3039" }, { "affs": [ 27 ], "name": "Oh Young Bang", "orcid": "0000-0002-7962-8751" }, { "affs": [ 28 ], "name": "Ji Hoe Heo", "orcid": "0000-0001-9898-3321" }, { "affs": [ 0 ], "name": "Hyo Suk Nam", "orcid": "0000-0002-4415-3995" }, { "name": "for the OPTIMAL-BP trial investigators" } ], "bibtex": "https://research.draconitic.com/paper/93rtar2x8dna4.bib", "cited_by": 0, "doi": "10.5469/neuroint.2026.00822", "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13725173/", "id": "93rtar2x8dna4", "issns": [ "2093-9043", "2233-6273" ], "landing_url": "https://doi.org/10.5469/neuroint.2026.00822", "language": "en", "licence": "CC-BY-NC-4.0", "licence_label": "CC BY-NC 4.0", "licence_source": "article", "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/", "metadata_licence": null, "native_subjects": [ [ "heading", "Original Paper" ], [ "openalex", "2713|Acute Ischemic Stroke Management" ] ], "openalex": "W7220898072", "pdf_url": "https://neurointervention.org/upload/pdf/neuroint-2026-00822.pdf", "pmcid": "PMC13725173", "pmid": "42844856", "published": "2026-10-08", "publisher": "Korean Society of Interventional Neuroradiolgy", "ris": "https://research.draconitic.com/paper/93rtar2x8dna4.ris", "sources": [ { "first_seen": "2026-11-04T12:23:37Z", "native_id": "PMC13725173", "source": "pmc", "url": "https://doi.org/10.5469/neuroint.2026.00822" } ], "subjects": [ { "field": "medicine", "origin": "openalex:2713|Acute Ischemic Stroke Management", "subfield": "epidemiology-public-health" } ], "title": "Association of Estimated Arterial Stiffness with Collateral Status and Functional Outcome after Endovascular Thrombectomy: A Secondary Analysis of the OPTIMAL-BP Trial", "title_text": "Association of Estimated Arterial Stiffness with Collateral Status and Functional Outcome after Endovascular Thrombectomy: A Secondary Analysis of the OPTIMAL-BP Trial", "type": "peer-reviewed", "updated_at": "2026-11-06T12:21:30Z", "url": "https://research.draconitic.com/paper/93rtar2x8dna4", "venue": "Neurointervention", "versions": [] }