{
  "abstract": "The emergence and rapid spread of methicillin-resistant Staphylococcus aureus (MRSA) have created an urgent need for new antibacterial agents capable of overcoming established resistance mechanisms. Among the diverse sulfur-containing scaffolds, thioethers have attracted increasing attention because of their structural versatility and ability to modulate antibacterial activity through incorporation into different pharmacophores. This review provides a comprehensive overview of synthetic, semisynthetic, and natural or natural-product-derived thioether compounds evaluated against MRSA, with emphasis on their structural features, structure-activity relationships (SAR), antibacterial potency, and mechanisms of action. The major classes discussed include aminoglycoside-derived thioether amphiphiles, membrane-active small-molecule thioethers, quinazolinone and quinoline thioether scaffolds, pleuromutilin thioether derivatives, SecA-targeting thioethers, chalcone and oxazolidinone derivatives, FtsZ-targeting thioethers, anti-virulence and antibiofilm agents, antimicrobial peptidomimetics, and natural-product-derived thioether compounds. The studies demonstrate that sulfur-containing motifs can contribute to anti-MRSA activity through membrane disruption, inhibition of bacterial protein synthesis and targeting of essential non-ribosomal proteins. The available SAR evidence highlights the scaffold-dependent nature of thioether activity and supports their continued exploration as versatile structural motifs for the development of new therapeutic strategies against drug-resistant MRSA.",
  "abstract_shown": true,
  "affiliations": [
    "Medicinal and Process Chemistry Division",
    "CSIR-Central Drug Research Institute",
    "Department of Chemistry",
    "Punjab Agricultural University",
    "Chemistry Division",
    "Indian Institute of Technology Roorkee"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 3,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Aditya G Lavekar"
    },
    {
      "affs": [
        2,
        3
      ],
      "name": "Radha Ahuja"
    },
    {
      "affs": [
        4,
        5
      ],
      "name": "Deepti Gairola"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/93taxsv0j2hgh.bib",
  "cited_by": 0,
  "doi": "10.26434/chemrxiv.15008364/v1",
  "fulltext_url": null,
  "id": "93taxsv0j2hgh",
  "issns": [],
  "landing_url": "https://chemrxiv.org/doi/full/10.26434/chemrxiv.15008364/v1",
  "language": null,
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2725|Antimicrobial Resistance in Staphylococcus"
    ]
  ],
  "openalex": "W7211897970",
  "pdf_url": "https://chemrxiv.org/doi/pdf/10.26434/chemrxiv.15008364/v1",
  "pmcid": null,
  "pmid": null,
  "published": "2026-09-06",
  "publisher": "American Chemical Society (ACS)",
  "ris": "https://research.draconitic.com/paper/93taxsv0j2hgh.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:17Z",
      "native_id": "10.26434/chemrxiv.15008364",
      "source": "chemrxiv",
      "url": "https://chemrxiv.org/doi/full/10.26434/chemrxiv.15008364/v2"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2725|Antimicrobial Resistance in Staphylococcus",
      "subfield": "infectious-disease"
    }
  ],
  "title": "THIOETHERS AS POTENTIAL ANTIBACTERIAL AGENTS AGAINST METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS (MRSA)",
  "title_text": "THIOETHERS AS POTENTIAL ANTIBACTERIAL AGENTS AGAINST METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS (MRSA)",
  "type": "preprint",
  "updated_at": "2026-10-30T12:17:19Z",
  "url": "https://research.draconitic.com/paper/93taxsv0j2hgh",
  "venue": "ChemRxiv",
  "versions": []
}