{
  "abstract": "Apigenin, a ubiquitous dietary flavone from vegetables, fruits and herbal teas, exhibits multi-target hypotensive effects, yet its poor water solubility limits oral bioavailability and industrial translation. Previous reviews only summarized its general bioactivities and anti-atherosclerotic effects, without comprehensively analyzing its antihypertensive mechanisms. Most evidence derives from preclinical studies; human trials merely use crude celery seed extracts instead of purified apigenin, lacking reliable clinical proof for its antihypertensive efficacy. This review summarizes apigenin’s sources, chemical properties, safety and solubility-enhanced delivery systems to support functional food exploitation. We elaborate four core antihypertensive pathways, and also point out translational bottlenecks and propose strategies including food-grade nanoformulation and standardized clinical trials. This work links preclinical mechanisms to food industry application, providing theoretical evidence for developing apigenin-enriched functional foods for hypertension adjuvant intervention.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Clinical Pharmacy, Hunan University of Medicine General Hospital, Huaihua, Hunan, People’s Republic of China",
    "Institute of Grand Health, Guangxi Academy of Sciences, Nanning, Guangxi, People’s Republic of China",
    "Department of Pharmacy, Xiangya Hospital, Changsha, Hunan, People’s Republic of China",
    "Department of Pharmacy, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, People’s Republic of China"
  ],
  "article_type": "review article",
  "arxiv": null,
  "author_total": 7,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Xiaolin Liao",
      "orcid": "0000-0003-4601-948X"
    },
    {
      "affs": [
        0
      ],
      "name": "Hangxing Huang"
    },
    {
      "affs": [
        0
      ],
      "name": "Junlong Cai"
    },
    {
      "affs": [
        1
      ],
      "name": "Huaguan Lu"
    },
    {
      "affs": [
        0,
        2
      ],
      "name": "Jing Li"
    },
    {
      "affs": [
        3
      ],
      "name": "Hongfang Li",
      "orcid": "0009-0007-0976-1825"
    },
    {
      "affs": [
        0,
        2
      ],
      "name": "Yueping Jiang"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/944jjb3yasrj9.bib",
  "cited_by": 0,
  "doi": "10.2147/dddt.s629109",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13738091/",
  "id": "944jjb3yasrj9",
  "issns": [
    "1177-8881"
  ],
  "landing_url": "https://doi.org/10.2147/dddt.s629109",
  "language": "en",
  "licence": "CC-BY-NC-4.0",
  "licence_label": "CC BY-NC 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Review"
    ],
    [
      "openalex",
      "2736|Flavonoids in Medical Research"
    ]
  ],
  "openalex": "W7224989640",
  "pdf_url": "https://www.dovepress.com/article/download/121652",
  "pmcid": "PMC13738091",
  "pmid": "42992106",
  "published": "2026-11-01",
  "publisher": "Dove Press",
  "ris": "https://research.draconitic.com/paper/944jjb3yasrj9.ris",
  "sources": [
    {
      "first_seen": "2026-11-09T12:23:08Z",
      "native_id": "PMC13738091",
      "source": "pmc",
      "url": "https://doi.org/10.2147/dddt.s629109"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2736|Flavonoids in Medical Research",
      "subfield": "pharmacology-toxicology"
    }
  ],
  "title": "Apigenin: Antihypertensive Effects and Underlying Mechanisms — A Comprehensive Review",
  "title_text": "Apigenin: Antihypertensive Effects and Underlying Mechanisms — A Comprehensive Review",
  "type": "peer-reviewed",
  "updated_at": "2026-11-09T12:23:08Z",
  "url": "https://research.draconitic.com/paper/944jjb3yasrj9",
  "venue": "Drug Design, Development and Therapy",
  "versions": []
}