{
  "abstract": "In the objective of exploiting the MnII/III redox couple combined with the bispidine scaffold for the development of redox-responsive magnetic resonance imaging (MRI) probes, we have designed and synthesized H3L1 ligand, featuring a phenol pendant arm. This novel ligand is hypothesized to lower the MnII/III redox potential relative to previously reported derivatives, while retaining the high kinetic inertness and good relaxivity properties characteristic of MnII bispidine complexes. The [MnIIL1(H2O)]- complex exhibits high thermodynamic stability (log KMnIIL1 = 14.2), notable kinetic inertness (dissociation half-life, t1/2 = 20.4 h at pH 6 in the presence of 50 equiv of ZnII), and high relaxivity (r1 = 3.91 mM–1s–1 at 60 MHz, 25 °C, pH 7), highlighting the suitability of the MnII complex as a platform for MRI probe development. Electrochemical studies revealed a significantly lower oxidation potential (E1/2 = 306 mV vs SCE) compared to other Mn-bispidine chelates, enabling successful synthesis of the oxidized [MnIIIL1] form in methanol. Although the aqueous stability of the +III oxidation state remains limited and highly dependent on water content, these results demonstrate that the incorporation of a phenolate donor effectively tunes the MnII/III redox properties of the bispidine scaffold.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 8,
  "authors": [
    {
      "name": "Anli Mahamoud"
    },
    {
      "name": "Zoltán Garda"
    },
    {
      "name": "Jean Bouvet"
    },
    {
      "name": "Daouda Ndiaye"
    },
    {
      "name": "Clotilde Policar"
    },
    {
      "name": "Mourad Elhabiri"
    },
    {
      "name": "Éva Tóth"
    },
    {
      "name": "Aline Nonat"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/947by26ccdy17.bib",
  "cited_by": 0,
  "doi": "10.1021/acs.inorgchem.6c01966",
  "fulltext_url": null,
  "id": "947by26ccdy17",
  "issns": [
    "0020-1669",
    "1520-510X"
  ],
  "landing_url": "https://hal.science/hal-05843456v1",
  "language": "en",
  "licence": "CC-BY-NC-ND-4.0",
  "licence_label": "CC BY-NC-ND 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "hal",
      "0.chim"
    ],
    [
      "openalex",
      "2505|Lanthanide and Transition Metal Complexes"
    ]
  ],
  "openalex": "W7170092189",
  "pdf_url": "https://hal.science/hal-05843456/document",
  "pmcid": null,
  "pmid": "42484020",
  "published": "2026-07-22",
  "publisher": "American Chemical Society",
  "ris": "https://research.draconitic.com/paper/947by26ccdy17.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:18:03Z",
      "native_id": "hal-05843456",
      "source": "hal",
      "url": "https://hal.science/hal-05843456v1"
    }
  ],
  "subjects": [
    {
      "field": "chemistry",
      "origin": "openalex:2505|Lanthanide and Transition Metal Complexes",
      "subfield": "materials-polymers"
    }
  ],
  "title": "Tuning the Redox Sensitivity of MnII/MnIII-Bispidine MRI Probes by the Introduction of a Phenolate Donor",
  "title_text": "Tuning the Redox Sensitivity of MnII/MnIII-Bispidine MRI Probes by the Introduction of a Phenolate Donor",
  "type": "peer-reviewed",
  "updated_at": "2026-10-31T12:20:56Z",
  "url": "https://research.draconitic.com/paper/947by26ccdy17",
  "venue": "Inorganic Chemistry",
  "versions": []
}