{
  "abstract": "A Rh(III)-catalyzed exclusive [4 + 2] cascade cyclization of 2-phenylbenzimidazoles with 3-methylmaleimides for the synthesis of spiro-fused benzimidazoisoquinoline succinimides via C-H activation is reported. The detailed mechanistic study revealed that the reaction proceeds through N-directed C-H activation of 2-phenylbenzimidazole. Subsequent migratory insertion of the rhodium-mediated formation of isomeric maleimide into the Rh-C bond and reductive elimination affords the polycyclic spiro-fused benzimidazoisoquinoline succinimide.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Applied Chemistry, Laboratory of Combinatorial Drug Design, National Yang-Ming Chiao-Tung University, Hsinchu300-10, Taiwan.",
    "Department of Chemistry, MES Abasaheb Garware College, Pune411004, Maharashtra, India.",
    "Department of Medicinal and Applied Chemistry, Kaohsiung Medical University, Kaohsiung807-08, Taiwan."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 4,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Wei-Jung Chiu"
    },
    {
      "affs": [
        0
      ],
      "name": "Meng-Han Shih"
    },
    {
      "affs": [
        1
      ],
      "name": "Indrajeet J Barve"
    },
    {
      "affs": [
        0,
        2
      ],
      "name": "Chung-Ming Sun",
      "orcid": "0000-0002-1804-1578"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/94by7khfe98b3.bib",
  "cited_by": 0,
  "doi": "10.1021/acs.orglett.6c03335",
  "fulltext_url": "https://europepmc.org/articles/PMC13640432",
  "id": "94by7khfe98b3",
  "issns": [
    "1523-7060",
    "1523-7052"
  ],
  "landing_url": "https://europepmc.org/article/MED/42917809",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1605|Catalytic C–H Functionalization Methods"
    ]
  ],
  "openalex": "W7213873963",
  "pdf_url": "https://europepmc.org/articles/PMC13640432?pdf=render",
  "pmcid": "PMC13640432",
  "pmid": "42917809",
  "published": "2026-10-01",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/94by7khfe98b3.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:20:36Z",
      "native_id": "MED:42917809",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42917809"
    }
  ],
  "subjects": [
    {
      "field": "chemistry",
      "origin": "openalex:1605|Catalytic C–H Functionalization Methods",
      "subfield": "organic"
    }
  ],
  "title": "Rh(III)-Catalyzed [4 + 2] Spiroannulation of 2-Phenylbenzimidazoles with Isomerizable 3-Methylmaleimides: Synthesis of Spiro-Fused Benzimidazoisoquinoline Succinimides.",
  "title_text": "Rh(III)-Catalyzed [4 + 2] Spiroannulation of 2-Phenylbenzimidazoles with Isomerizable 3-Methylmaleimides: Synthesis of Spiro-Fused Benzimidazoisoquinoline Succinimides.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:20:36Z",
  "url": "https://research.draconitic.com/paper/94by7khfe98b3",
  "venue": "Organic letters",
  "versions": []
}