{
  "abstract": "Periodontitis is a prevalent chronic inflammatory disease characterized by gingival inflammation and progressive alveolar bone loss. The NLRP3 inflammasome functions as a molecular mediator that drives its pathogenesis. Bergapten (BeG), a natural furanocoumarin, exhibits anti-inflammatory properties and bone-protective effects. This study demonstrates that BeG alleviates experimental periodontitis in mice by inhibiting the NLRP3 inflammasome. Mechanistically, BeG does not affect NLRP3 priming, dispersed trans-Golgi network (dTGN) localization, or oligomerization; instead, it induces mitophagy by inhibiting the AKT-mTOR axis and consequently suppresses the mtROS-dependent NEK7-NLRP3 interaction. Notably, BeG also suppressed cytosolic release of oxidized mitochondrial DNA (ox-mtDNA), a known endogenous ligand for NLRP3. This effect was attributed to BeG-mediated inhibition of NLRP3 activation, likely via blockade of GSDMD-NT mitochondrial localization. These findings deepen our understanding of the anti-inflammatory mechanisms of BeG and position it as a promising candidate for periodontitis treatment.",
  "abstract_shown": true,
  "affiliations": [
    "Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University, Xi'an 710004, China.",
    "Clinical Research Center of Shaanxi Province for Dental and Maxillofacial Diseases, College of Stomatology, Xi'an Jiaotong University, Xi'an 710004, China.",
    "Department of Urology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, China.",
    "Key Laboratory for Tumor Precision Medicine of Shaanxi Province, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, China.",
    "Engineering Research Center of Tibetan Medicine Detection Technology, Ministry of Education, School of Medicine, Xizang Minzu University, Xianyang 712082, China.",
    "Department of Implant Dentistry, College of Stomatology, Xi'an Jiaotong University, Xi'an 710004, China."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 9,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Xiangbin Jia"
    },
    {
      "affs": [
        2,
        3
      ],
      "name": "Yuzhao Wang"
    },
    {
      "affs": [
        4
      ],
      "name": "Jiao Cao"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Lifei Pan"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Xiaoxuan Cui"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Hanxue Shan"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Yiqing Wang"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Xiao Cao"
    },
    {
      "affs": [
        0,
        1,
        5
      ],
      "name": "Qin Zhou",
      "orcid": "0000-0001-6549-4740"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/94ct9zchhhnmz.bib",
  "cited_by": 0,
  "doi": "10.3390/antiox15101304",
  "fulltext_url": "https://europepmc.org/articles/PMC13700881",
  "id": "94ct9zchhhnmz",
  "issns": [
    "2076-3921"
  ],
  "landing_url": "https://europepmc.org/article/MED/42939878",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1312|Inflammasome and immune disorders"
    ]
  ],
  "openalex": "W7221129771",
  "pdf_url": "https://europepmc.org/articles/PMC13700881?pdf=render",
  "pmcid": "PMC13700881",
  "pmid": "42939878",
  "published": "2026-10-09",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/94ct9zchhhnmz.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:22:24Z",
      "native_id": "MED:42939878",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42939878"
    }
  ],
  "subjects": [
    {
      "field": "biochemistry",
      "origin": "openalex:1312|Inflammasome and immune disorders",
      "subfield": "molecular-biology"
    }
  ],
  "title": "Bergapten Alleviates Periodontitis by Suppressing NLRP3 Inflammasome Activation via Mitophagy-Induced Disruption of NEK7-NLRP3 Interaction.",
  "title_text": "Bergapten Alleviates Periodontitis by Suppressing NLRP3 Inflammasome Activation via Mitophagy-Induced Disruption of NEK7-NLRP3 Interaction.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:22:24Z",
  "url": "https://research.draconitic.com/paper/94ct9zchhhnmz",
  "venue": "Antioxidants (Basel, Switzerland)",
  "versions": []
}