{
  "abstract": "Circadian rhythms, serving as a crucial temporal bridge linking neural activity and pathological biology, are regulated by central pacemaker neurons to maintain cellular homeostasis and coordinate diverse biological processes. Circadian rhythm disruption is closely associated with various diseases, including neurodegenerative disorders, metabolic disorders, and cancer. Circadian rhythms are controlled by core clock genes, such as BMAL1 and CLOCK, modulating numerous physiological processes, encompassing metabolism, immune responses, neural activity, and hormone regulation. Circadian rhythms disruptions arising from shift work, jet lag, or inconsistent sleep schedules are implicated in both the onset and progression of numerous diseases, notably Alzheimer's disease, Parkinson's disease, diabetes, and cardiovascular disease. The article highlights how circadian dysregulation alters cellular processes to potentially accelerate disease progression. Circadian disruption results in impaired immune function, further promoting disease development and resistance to treatment. Potential therapeutic applications based on circadian biology, such as chronotherapy and personalized medicine, are also discussed. Recent technological advances, embodied in wearable devices and omics approaches, are increasingly providing deeper insights into circadian biology. Further unveiling the role of circadian in health and disease opens new avenues for tailoring treatment timing to patients' biological rhythms, thereby enhancing therapeutic outcomes across various diseases. By bridging fundamental circadian mechanisms with clinical pathology, this review provides a roadmap for future chronotherapeutic interventions in precision medicine.",
  "abstract_shown": true,
  "affiliations": [
    "College of Life and Health Sciences, Northeastern University, Shenyang, 110169, China.",
    "Frontiers Science Center for Molecular Design Breeding (MOE), State Key Laboratory of Animal Biotech Breeding, College of Biological Sciences, China Agricultural University, Beijing, China.",
    "Institute of Neurology, Jiangxi Academy of Clinical Medical Sciences, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, 330200, China.",
    "Joint Research Center of Wenzhou Institute, University of Chinese Academy of Sciences, and the Second Affiliated Hospital, Wenzhou Medical University, Wenzhou, 325000, Zhejiang, China.",
    "Human Phenome Institute, Fudan University, Shanghai, 201203, China.",
    "Department of Infectious Diseases and Center of Infectious Diseases and Pathogen Biology, The First Hospital of Jilin University, Changchun, China.",
    "Xinjiang Key Laboratory of Reproductive Regulation and Breeding for Ruminant Livestock, Urumqi, Xinjiang, 830000, China.",
    "Joint Research Center of Wenzhou Institute, University of Chinese Academy of Sciences, and the Second Affiliated Hospital, Wenzhou Medical University, Wenzhou, 325000, Zhejiang, China. minwoo2022@126.com.",
    "Human Phenome Institute, Fudan University, Shanghai, 201203, China. minwoo2022@126.com.",
    "Department of Infectious Diseases and Center of Infectious Diseases and Pathogen Biology, The First Hospital of Jilin University, Changchun, China. minwoo2022@126.com.",
    "College of Life and Health Sciences, Northeastern University, Shenyang, 110169, China. huangyongye88@163.com.",
    "National Key Laboratory for Swine Genetic Improvement and Germplasm Innovation, Ministry of Science and Technology of China, Jiangxi Agricultural University, Nanchang, 330045, China. huangyongye88@163.com."
  ],
  "article_type": "review article",
  "arxiv": null,
  "author_total": 11,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Xiaoyan Liu"
    },
    {
      "affs": [
        1
      ],
      "name": "Xuguang Du"
    },
    {
      "affs": [
        0
      ],
      "name": "Shihong Qi"
    },
    {
      "affs": [
        2
      ],
      "name": "Lin Yuan"
    },
    {
      "affs": [
        3,
        4
      ],
      "name": "Liyu Liu"
    },
    {
      "affs": [
        5
      ],
      "name": "Kaiyu Zhang"
    },
    {
      "affs": [
        6
      ],
      "name": "Liqin Wang"
    },
    {
      "affs": [
        0
      ],
      "name": "Wanlu Zhang"
    },
    {
      "affs": [
        3
      ],
      "name": "Qian Liu"
    },
    {
      "affs": [
        7,
        8,
        9
      ],
      "name": "Min Wu"
    },
    {
      "affs": [
        10,
        11
      ],
      "name": "Yongye Huang",
      "orcid": "0000-0002-9083-250X"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/94fmqhx565dv0.bib",
  "cited_by": 0,
  "doi": "10.1186/s43556-026-00646-7",
  "fulltext_url": "https://europepmc.org/articles/PMC13694672",
  "id": "94fmqhx565dv0",
  "issns": [
    "2662-8651"
  ],
  "landing_url": "https://europepmc.org/article/MED/42909824",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "lcc",
      "R"
    ],
    [
      "openalex",
      "2807|Circadian rhythm and melatonin"
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  "openalex": "W7223304976",
  "pdf_url": "https://europepmc.org/articles/PMC13694672?pdf=render",
  "pmcid": "PMC13694672",
  "pmid": "42909824",
  "published": "2026-10-23",
  "publisher": "Springer",
  "ris": "https://research.draconitic.com/paper/94fmqhx565dv0.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:20:03Z",
      "native_id": "MED:42909824",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42909824"
    },
    {
      "first_seen": "2026-10-30T13:45:34Z",
      "native_id": "76a74da92afb477bb1589c2004f57034",
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      "url": "https://doi.org/10.1186/s43556-026-00646-7"
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  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2807|Circadian rhythm and melatonin",
      "subfield": "physiology"
    }
  ],
  "title": "Circadian rhythms in health and disease.",
  "title_text": "Circadian rhythms in health and disease.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T13:45:34Z",
  "url": "https://research.draconitic.com/paper/94fmqhx565dv0",
  "venue": "Molecular biomedicine",
  "versions": []
}