{
  "abstract": "Diabetic wounds are highly susceptible to chronicity and infection due to impaired healing involving multiple pathophysiological factors. Despite extensive preclinical and clinical research, few approved drugs have been shown to effectively accelerate diabetic wound healing. This review highlights pharmacological interventions for diabetic wound healing, summarizes the current status of drug development, and discusses their potential mechanisms of action. These agents include inflammation-modulating agents, pro-proliferative agents, remodeling-regulating agents, hypoxia- and microcirculation-targeting agents, antioxidant agents, and multi-target agents, such as bioactive constituents from plants and traditional Chinese medicine (TCM) formulas. This review aims to guide future drug development strategies for diabetic wound healing.",
  "abstract_shown": true,
  "affiliations": [
    "Beijing Key Laboratory of Innovative Drug Discovery and Polymorphic Druggability Research for Cerebrovascular Diseases, Institute of Materia Medica of Peking Union Medical College, Beijing 100050, China",
    "Department of Pharmacy, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua Medicine, Tsinghua University, Beijing 102218, China"
  ],
  "article_type": "review article",
  "arxiv": null,
  "author_total": 10,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Jiamin Shang"
    },
    {
      "affs": [
        0
      ],
      "name": "Zhaoyu Liu"
    },
    {
      "affs": [
        1
      ],
      "name": "Meidai Liang"
    },
    {
      "affs": [
        0
      ],
      "name": "Xiaomeng Ye"
    },
    {
      "affs": [
        0
      ],
      "name": "Zijie Yin"
    },
    {
      "affs": [
        0
      ],
      "name": "Zeyu Yang"
    },
    {
      "affs": [
        0
      ],
      "name": "Jiaqi Zhao"
    },
    {
      "affs": [
        0
      ],
      "name": "Hongjing Wu"
    },
    {
      "affs": [
        0
      ],
      "name": "Guanhua Du"
    },
    {
      "affs": [
        0
      ],
      "name": "Xiuying Yang"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/94h4rejc1kxx7.bib",
  "cited_by": 0,
  "doi": "10.1016/j.apsb.2026.09.007",
  "fulltext_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13729541/?tool=EBI",
  "id": "94h4rejc1kxx7",
  "issns": [
    "2211-3835",
    "2211-3843"
  ],
  "landing_url": "https://europepmc.org/article/PMC/PMC13729541",
  "language": "eng",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Review"
    ],
    [
      "openalex",
      "2746|Wound Healing and Treatments"
    ]
  ],
  "openalex": "W7212376466",
  "pdf_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13729541/pdf/?tool=EBI",
  "pmcid": "PMC13729541",
  "pmid": "42979440",
  "published": "2026-09-12",
  "publisher": "Elsevier",
  "ris": "https://research.draconitic.com/paper/94h4rejc1kxx7.ris",
  "sources": [
    {
      "first_seen": "2026-11-04T15:20:47Z",
      "native_id": "PMC:PMC13729541",
      "source": "europepmc",
      "url": "https://europepmc.org/article/PMC/PMC13729541"
    },
    {
      "first_seen": "2026-11-07T12:22:16Z",
      "native_id": "PMC13729541",
      "source": "pmc",
      "url": "https://doi.org/10.1016/j.apsb.2026.09.007"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2746|Wound Healing and Treatments",
      "subfield": "surgery"
    }
  ],
  "title": "Pharmacological agents for promoting diabetic wound healing",
  "title_text": "Pharmacological agents for promoting diabetic wound healing",
  "type": "peer-reviewed",
  "updated_at": "2026-11-07T12:22:16Z",
  "url": "https://research.draconitic.com/paper/94h4rejc1kxx7",
  "venue": "Acta pharmaceutica Sinica. B",
  "versions": []
}