{
  "abstract": "Proteolytic imbalance involving host and microbial serine proteases and their inhibitors (serpins) contributes to intestinal barrier disruption and chronic inflammation in inflam matory bowel disease (IBD). However, the interplay among these components remains insufficiently characterized. Here, we survey 13,304 publications over five decades, to map protease-serpin-microbiome literature in IBD. Our analysis reveals a fragmented literature structure, with uneven coverage and limited cross-domain integration among host proteases, microbial proteases, and inhibitory pathways. We synthesize evidence linking these components to intestinal barrier integrity, mucosal immunity, extracellular-matrix remodeling, and microbial ecology. Considering the proteaseserpin-microbiome axis may provide an integrative direction for future studies of IBD pathogenesis, including the investigation of mechanisms underlying disease heteroge neity, prioritizing future biomarker and therapeutic studies.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 13,
  "authors": [
    {
      "name": "Meshal Almalki"
    },
    {
      "name": "Camilla R de Pierri"
    },
    {
      "name": "Tristan Méric"
    },
    {
      "name": "Héla Mkaouar"
    },
    {
      "name": "Donia Slimani"
    },
    {
      "name": "Vincent Mariaule"
    },
    {
      "name": "Sirine Tebassi"
    },
    {
      "name": "Nizar Akermi"
    },
    {
      "name": "Emmanuelle Maguin"
    },
    {
      "name": "Juan Hernandez"
    },
    {
      "name": "Roberto T Raittz"
    },
    {
      "name": "Moez Rhimi"
    },
    {
      "name": "Francesco Asnicar"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/94hdzb4ns1shd.bib",
  "cited_by": 0,
  "doi": "10.1080/19490976.2026.2726641",
  "fulltext_url": null,
  "id": "94hdzb4ns1shd",
  "issns": [
    "1949-0976",
    "1949-0984"
  ],
  "landing_url": "https://hal.science/hal-05736225v1",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "hal",
      "0.sdv"
    ],
    [
      "hal",
      "1.sdv.ba"
    ],
    [
      "hal",
      "1.sdv.bbm"
    ],
    [
      "hal",
      "1.sdv.mp"
    ],
    [
      "openalex",
      "1311|Inflammatory Bowel Disease"
    ]
  ],
  "openalex": "W7205006067",
  "pdf_url": "https://hal.science/hal-05736225/document",
  "pmcid": null,
  "pmid": null,
  "published": "2026-09-02",
  "publisher": "Taylor & Francis",
  "ris": "https://research.draconitic.com/paper/94hdzb4ns1shd.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:27Z",
      "native_id": "hal-05736225",
      "source": "hal",
      "url": "https://hal.science/hal-05736225v1"
    }
  ],
  "subjects": [
    {
      "field": "biochemistry",
      "origin": "hal:1.sdv.bbm",
      "subfield": "general"
    },
    {
      "field": "biology",
      "origin": "hal:1.sdv.mp",
      "subfield": "microbiology"
    },
    {
      "field": "biology",
      "origin": "hal:1.sdv.ba",
      "subfield": "zoology-behaviour"
    }
  ],
  "title": "Protease-serpin-microbiome interactions in inflammatory bowel disease: toward integrated biomarkers of gut health",
  "title_text": "Protease-serpin-microbiome interactions in inflammatory bowel disease: toward integrated biomarkers of gut health",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:27Z",
  "url": "https://research.draconitic.com/paper/94hdzb4ns1shd",
  "venue": "Gut microbes",
  "versions": []
}