{
  "abstract": "BACKGROUND: SPES links municipal-cluster biomonitoring with questionnaire data in Campania. We evaluated associations between food-frequency questionnaire (FFQ)-derived food-source patterns, water intake, and serum trace-element biomarkers. METHODS: This cross-sectional analysis included 4137 diet responders. Fifteen food-density groups and water were modelled with covariate adjustment and municipal-cluster random intercepts. Below-LOQ values underwent censoring-aware multiple imputation; false discovery rate (FDR) control was applied within prespecified families. Primary endpoints were Hg-202, As-75, Cd-111, Pb-208, and Ni-60. RESULTS: Five of 65 primary tests met the FDR threshold. Per interquartile-range (IQR) increase, seafood total density was associated with higher As-75 (geometric mean ratio [GMR] 1.238, 95% CI 1.147-1.335) and Hg-202 (GMR 1.145, 1.084-1.210). Sentinel models showed positive associations of fish and crustaceans/molluscs with As-75 and of fish with Hg-202. Quartile, spline, measured-only, energy-intake, and alcohol-adjusted analyses supported these findings. No association met the FDR threshold for Cd-111, Pb-208, or Ni-60. CONCLUSIONS: Seafood intake was associated with total serum Hg-202 and As-75. Because As-75 was non-speciated and may partly reflect recent seafood-derived organic arsenic, its toxicological significance was uncertain. The design did not establish speciation, source, causality, or individual clinical risk.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Precision Medicine, University of Campania “Luigi Vanvitelli”, Via Luigi De Crecchio 7, 80138 Naples, Italy",
    "Department of Public Health, University of Naples “Federico II”, Via Sergio Pansini 5, 80131 Naples, Italy",
    "Department of Human Sciences and Quality of Life Promotion, San Raffaele University, 00166 Rome, Italy"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 9,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Annachiara Coppola",
      "orcid": "0000-0003-4818-9714"
    },
    {
      "affs": [
        1
      ],
      "name": "Paolo Montuori",
      "orcid": "0000-0002-8745-232X"
    },
    {
      "affs": [
        2,
        1
      ],
      "name": "Maria Triassi",
      "orcid": "0000-0002-9420-9571"
    },
    {
      "affs": [
        0
      ],
      "name": "Alessandro Federico",
      "orcid": "0000-0002-0885-0793"
    },
    {
      "affs": [
        0
      ],
      "name": "Marcello Dallio",
      "orcid": "0000-0003-4153-815X"
    },
    {
      "affs": [
        1
      ],
      "name": "Fabiana Di Duca",
      "orcid": "0000-0002-8677-8619"
    },
    {
      "affs": [
        2,
        1
      ],
      "name": "Elvira De Rosa"
    },
    {
      "affs": [
        1
      ],
      "name": "Carlo Buonerba",
      "orcid": "0000-0002-1806-442X"
    },
    {
      "affs": [
        1
      ],
      "name": "Pellegrino Cerino",
      "orcid": "0009-0009-7944-239X"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/94v8gqqzeq103.bib",
  "cited_by": 5,
  "doi": "10.3390/jox16040153",
  "fulltext_url": null,
  "id": "94v8gqqzeq103",
  "issns": [
    "2039-4705",
    "2039-4713"
  ],
  "landing_url": "https://doi.org/10.3390/jox16040153",
  "language": "en",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2307|Heavy Metal Exposure and Toxicity"
    ]
  ],
  "openalex": "W7203747140",
  "pdf_url": null,
  "pmcid": "PMC13514463",
  "pmid": "42646067",
  "published": "2026-08-19",
  "publisher": "PAGEPress (Italy)",
  "ris": "https://research.draconitic.com/paper/94v8gqqzeq103.ris",
  "sources": [
    {
      "first_seen": "2026-10-31T13:20:53Z",
      "native_id": "W7203747140",
      "source": "openalex",
      "url": "https://doi.org/10.3390/jox16040153"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2307|Heavy Metal Exposure and Toxicity",
      "subfield": "pharmacology-toxicology"
    }
  ],
  "title": "Food-Source Patterns and Serum Trace-Metal Biomarkers in the SPES Population Biomonitoring Study, Campania, Italy",
  "title_text": "Food-Source Patterns and Serum Trace-Metal Biomarkers in the SPES Population Biomonitoring Study, Campania, Italy",
  "type": "peer-reviewed",
  "updated_at": "2026-11-07T13:21:03Z",
  "url": "https://research.draconitic.com/paper/94v8gqqzeq103",
  "venue": "Journal of Xenobiotics",
  "versions": []
}