{
  "abstract": "Objective\n\nTo assess post-vaccination changes in chemosensory function among individuals with and without COVID-19-related chemosensory impairment.Methods\n\nIn this global, multilingual online survey, participants reported vaccination status, vaccine side effects, and changes in smell and taste before and after each vaccine dose. Responses were collected between May 2022 and August 2023 through convenience sampling. Of 2955 responses, 1352 were included after applying exclusion criteria.Results\n\nPfizer-BioNTech accounted for 46.2% of vaccine doses, followed by Sputnik V (16.3%), Moderna (15.4%), AstraZeneca (8.9%), and Sinopharm (7.4%). More than 90% of participants reported no change in general smell or taste following vaccination, regardless of pre-existing chemosensory impairment. Among participants with qualitative chemosensory distortions, improvement was reported by 11%-18% for parosmia, 20%-29% for phantosmia, and 12%-21% for distorted taste, depending on vaccine dose, whereas worsening was reported by 3% or fewer. Side effects varied by vaccine type and were more frequent among individuals reporting worsened chemosensory symptoms.Conclusion\n\nMost participants reported stable smell and taste perception following vaccination. A subset of individuals with qualitative chemosensory distortions reported improvement, while worsening was uncommon.",
  "abstract_shown": true,
  "affiliations": [
    "Indiana University School of Medicine Indianapolis Indiana USA.",
    "Department of Molecular Medicine University of Padova Padova Italy.",
    "Severtsov Institute of Ecology & Evolution, Russian Academy of Sciences Moscow Russia.",
    "Centre de Recherche du CHU de Québec, Laval University Quebec Canada.",
    "Institute for Molecular Bioscience, The University of Queensland Brisbane Queensland Australia.",
    "Department of Neuroscience, Reproductive and Dentistry Science, ENT Unit Federico II University of Naples Naples Italy.",
    "Shiraz Institute for Stem Cell & Regenerative Medicine, Shiraz University of Medical Sciences Shiraz Iran.",
    "Food Quality and Technology, IRTA-Food Research Institute Monells Spain.",
    "The Department of Otolaryngology Head and Neck Surgery Second Affiliated Hospital of Xi'an Jiaotong University Xi'an China.",
    "Monell Chemical Senses Center Philadelphia Pennsylvania USA.",
    "Science & Research, dsm-firmenich Satigny Switzerland."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 18,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Sachiko Koyama",
      "orcid": "0000-0002-6886-1961"
    },
    {
      "affs": [
        1
      ],
      "name": "Carla Mucignat-Caretta"
    },
    {
      "affs": [
        2
      ],
      "name": "Maria A Klyuchnikova",
      "orcid": "0000-0001-9254-8927"
    },
    {
      "affs": [
        2
      ],
      "name": "Tatiana K Laktionova"
    },
    {
      "affs": [
        3
      ],
      "name": "Svetlana Kopishinskaia"
    },
    {
      "affs": [
        2
      ],
      "name": "Ilya G Kvasha"
    },
    {
      "affs": [
        4
      ],
      "name": "Junpeng Ye"
    },
    {
      "affs": [
        5
      ],
      "name": "Elena Cantone",
      "orcid": "0000-0002-7389-2033"
    },
    {
      "affs": [
        6
      ],
      "name": "Shima Parsa"
    },
    {
      "affs": [
        7
      ],
      "name": "Maria Dolors Guàrdia"
    },
    {
      "affs": [
        4
      ],
      "name": "Valentin Hivert",
      "orcid": "0000-0002-5144-6956"
    },
    {
      "affs": [
        4
      ],
      "name": "Solal Chauquet"
    },
    {
      "affs": [
        8
      ],
      "name": "Jingguo Chen",
      "orcid": "0000-0002-7051-4037"
    },
    {
      "affs": [
        4
      ],
      "name": "Giulio Centorame"
    },
    {
      "affs": [
        9
      ],
      "name": "Valentina Parma",
      "orcid": "0000-0003-0276-7072"
    },
    {
      "affs": [
        10
      ],
      "name": "Kathrin Ohla"
    },
    {
      "affs": [
        2
      ],
      "name": "Vera V Voznessenskaya"
    },
    {
      "affs": [
        4,
        9
      ],
      "name": "Liang-Dar Hwang",
      "orcid": "0000-0002-5535-2199"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/94ygzeqakv2nh.bib",
  "cited_by": 0,
  "doi": "10.1002/lio2.70589",
  "fulltext_url": "https://europepmc.org/articles/PMC13679654",
  "id": "94ygzeqakv2nh",
  "issns": [
    "2378-8038"
  ],
  "landing_url": "https://europepmc.org/article/MED/42898918",
  "language": "eng",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2809|Olfactory and Sensory Function Studies"
    ]
  ],
  "openalex": "W7222928631",
  "pdf_url": "https://europepmc.org/articles/PMC13679654?pdf=render",
  "pmcid": "PMC13679654",
  "pmid": "42898918",
  "published": "2026-10-19",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/94ygzeqakv2nh.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:32Z",
      "native_id": "MED:42898918",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42898918"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:2809|Olfactory and Sensory Function Studies",
      "subfield": "neuroscience"
    }
  ],
  "title": "Post-Vaccination Chemosensory Dysfunction: Changes Following SARS-CoV-2 Vaccination in a Global Study.",
  "title_text": "Post-Vaccination Chemosensory Dysfunction: Changes Following SARS-CoV-2 Vaccination in a Global Study.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:19:32Z",
  "url": "https://research.draconitic.com/paper/94ygzeqakv2nh",
  "venue": "Laryngoscope investigative otolaryngology",
  "versions": []
}