{
  "abstract": "Myeloperoxidase (MPO)-derived hypochlorous acid (HClO) is a key oxidant in inflammatory diseases such as sepsis and neuroinflammation. Selective detection of MPO-derived HClO in complex biological matrices remains challenging. 19F NMR spectroscopy offers zero-background, environment-sensitive chemical shifts and easy quantification. Herein, we report a series of drug-derived, nitrone-based 19F NMR probes (19FP-1 to 19FP-14) that respond specifically to HClO via nitrone oxidation, producing a distinct 19F chemical shift change. Systematic screening identified 19FP-10 as the optimal probe, exhibiting a chemical shift change of >2 ppm, high selectivity over other reactive oxygen species, and a linear concentration-dependent response to HClO. Importantly, 19FP-10 enables effective detection of HClO in mouse plasma from a sepsis model and discriminates between inflamed and healthy brain tissue in a neuroinflammation model. Additionally, 19FP-10 protects cells from oxidative stress and exhibits good in vivo biosafety, underscoring its translational potential. This work successfully establishes a class of activatable 19F NMR probes based on drug scaffolds, featuring both low toxicity and high selectivity, providing a clinically translatable molecular tool for assessing MPO-associated inflammation.",
  "abstract_shown": true,
  "affiliations": [
    "State Key Laboratory of Microbial Technology, Department of Radiology, Nanjing Drum Tower Hospital, Jiangsu Collaborative Innovation Center of Biomedical Functional Materials, School of Chemistry and Materials Science, Nanjing Normal University Nanjing 210023 China",
    "Department of Radiology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University Nanjing 210008 China"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 7,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Xiangjie Luo",
      "orcid": "0009-0006-0266-2536"
    },
    {
      "affs": [
        0
      ],
      "name": "Xinran Ji"
    },
    {
      "affs": [
        0
      ],
      "name": "Zhuoying Chen"
    },
    {
      "affs": [
        0
      ],
      "name": "Haoyu Wu"
    },
    {
      "affs": [
        1
      ],
      "name": "Han Cheng"
    },
    {
      "affs": [
        1
      ],
      "name": "Bing Zhang"
    },
    {
      "affs": [
        0
      ],
      "name": "Yong Qian"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/9553wtwbg2qmy.bib",
  "cited_by": 0,
  "doi": "10.1039/d6sc06063c",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13595111/",
  "id": "9553wtwbg2qmy",
  "issns": [
    "2041-6520",
    "2041-6539"
  ],
  "landing_url": "https://doi.org/10.1039/d6sc06063c",
  "language": "en",
  "licence": "CC-BY-NC-3.0",
  "licence_label": "CC BY-NC 3.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/3.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Chemistry"
    ],
    [
      "openalex",
      "1607|Molecular Sensors and Ion Detection"
    ]
  ],
  "openalex": "W7213983090",
  "pdf_url": "https://pubs.rsc.org/sc/article-pdf/doi/10.1039/d6sc06063c/14750918/d6sc06063c.pdf",
  "pmcid": "PMC13595111",
  "pmid": "42775038",
  "published": "2026-09-22",
  "publisher": "Royal Society of Chemistry",
  "ris": "https://research.draconitic.com/paper/9553wtwbg2qmy.ris",
  "sources": [
    {
      "first_seen": "2026-11-07T12:23:31Z",
      "native_id": "PMC13595111",
      "source": "pmc",
      "url": "https://doi.org/10.1039/d6sc06063c"
    }
  ],
  "subjects": [
    {
      "field": "chemistry",
      "origin": "openalex:1607|Molecular Sensors and Ion Detection",
      "subfield": "physical"
    }
  ],
  "title": "Activatable 19F NMR probes from drug scaffolds for assessing myeloperoxidase-associated inflammation",
  "title_text": "Activatable 19F NMR probes from drug scaffolds for assessing myeloperoxidase-associated inflammation",
  "type": "peer-reviewed",
  "updated_at": "2026-11-08T12:21:00Z",
  "url": "https://research.draconitic.com/paper/9553wtwbg2qmy",
  "venue": "Chemical Science",
  "versions": []
}