{
  "abstract": "Introduction\n\nMalignant melanoma (MM) is among the most lethal skin cancers, with rising global incidence and persistent mortality disparities. In the United States, long-term trends in MM-related mortality and their variation across demographic and geographic subgroups remain incompletely defined.Methods\n\nWe conducted a population-based analysis of MM mortality in the United States from 1999 to 2024, using national mortality data. Age-adjusted mortality rates per 100 000 population were calculated and stratified by sex, age, race/ethnicity, geographic region, and urbanization level. Temporal trends were evaluated using annual percent changes.Results\n\nBetween 1999 and 2024, MM mortality demonstrated dynamic shifts, with an initial increase followed by a decline and stabilization after 2017. Men consistently exhibited higher mortality rates than women, and older adults experienced disproportionately greater burdens. Racial and ethnic minorities, despite a lower incidence, showed poorer survival. Geographic variation was evident, with elevated mortality in certain states and in non-metropolitan areas relative to metropolitan regions. The decline in mortality corresponded temporally with the introduction of immune checkpoint inhibitors and targeted therapies, although disparities persisted across subgroups.Conclusion\n\nMM mortality in the United States has improved over the past two decades, largely due to advances in treatment. However, enduring disparities by sex, age, race and ethnicity, and geography emphasize the need for equitable access to therapies, improved early detection, and targeted public health interventions to sustain progress and reduce inequities.",
  "abstract_shown": true,
  "affiliations": [
    "King Abdullah Bin Abdulaziz University Hospital, Riyadh, Saudi Arabia",
    "College of Medicine, Imam Mohammad Ibn Saud Islamic University, Riyadh, Saudi Arabia",
    "College of Medicine, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia",
    "Liaquat University of Medical and Health Sciences, Jamshoro, Pakistan",
    "College of Medicine, Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia",
    "College of Medicine, Qassim University, Unaizah, Qassim, Saudi Arabia",
    "College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia",
    "College of Medicine, Jouf University, Al Jouf, Saudi Arabia",
    "College of Medicine, King Saud University, Riyadh, Saudi Arabia",
    "Department of Dermatology, King Faisal Specialist Hospital & Research Centre (KFSHRC), Riyadh, Saudi Arabia",
    "College of Medicine, Najran University, Najran, Saudi Arabia",
    "Department of Internal Medicine, Faculty of Medical Sciences, Lebanese University, Beirut, Lebanon"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 14,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Ibraheem Altamimi"
    },
    {
      "affs": [
        1
      ],
      "name": "Maha Mohammed Alkharisi"
    },
    {
      "affs": [
        2
      ],
      "name": "Naif Mohammed Alzahrani"
    },
    {
      "affs": [
        3
      ],
      "name": "Nimerta Lohana"
    },
    {
      "affs": [
        4
      ],
      "name": "Abeer Abdulkarim Aloraini"
    },
    {
      "affs": [
        5
      ],
      "name": "Abdelmalek Ammar AlHaj Abdelghani"
    },
    {
      "affs": [
        6
      ],
      "name": "Hoor Jawad Alalwan"
    },
    {
      "affs": [
        7
      ],
      "name": "Lojain Abdulsalam Alkhaldi"
    },
    {
      "affs": [
        8
      ],
      "name": "Abdulrhman Abdulaziz Alnoshan"
    },
    {
      "affs": [
        9
      ],
      "name": "Abdullah Almeziny"
    },
    {
      "affs": [
        10
      ],
      "name": "Hind Hussain Alghtani"
    },
    {
      "affs": [
        8
      ],
      "name": "Lubna Musa Altamimi"
    },
    {
      "affs": [
        0
      ],
      "name": "Haifa Alfalah"
    },
    {
      "affs": [
        11
      ],
      "name": "Aalaa Saleh"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/956f1v1psmdx7.bib",
  "cited_by": 0,
  "doi": "10.1097/ms9.0000000000005737",
  "fulltext_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13754381/?tool=EBI",
  "id": "956f1v1psmdx7",
  "issns": [
    "2049-0801"
  ],
  "landing_url": "https://europepmc.org/article/PMC/PMC13754381",
  "language": "eng",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Cross-sectional Study"
    ],
    [
      "openalex",
      "2730|Cutaneous Melanoma Detection and Management"
    ]
  ],
  "openalex": "W7225699554",
  "pdf_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13754381/pdf/?tool=EBI",
  "pmcid": "PMC13754381",
  "pmid": "43017689",
  "published": "2026-10-27",
  "publisher": "Wolters Kluwer Health",
  "ris": "https://research.draconitic.com/paper/956f1v1psmdx7.ris",
  "sources": [
    {
      "first_seen": "2026-11-12T15:23:59Z",
      "native_id": "PMC:PMC13754381",
      "source": "europepmc",
      "url": "https://europepmc.org/article/PMC/PMC13754381"
    },
    {
      "first_seen": "2026-11-15T03:20:07Z",
      "native_id": "MED:43017689",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/43017689"
    },
    {
      "first_seen": "2026-11-15T12:23:18Z",
      "native_id": "PMC13754381",
      "source": "pmc",
      "url": "https://doi.org/10.1097/ms9.0000000000005737"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2730|Cutaneous Melanoma Detection and Management",
      "subfield": "oncology"
    }
  ],
  "title": "Trends in malignant melanoma mortality in the United States, 1999–2024: a population-based retrospective epidemiologic analysis",
  "title_text": "Trends in malignant melanoma mortality in the United States, 1999–2024: a population-based retrospective epidemiologic analysis",
  "type": "peer-reviewed",
  "updated_at": "2026-11-15T12:23:18Z",
  "url": "https://research.draconitic.com/paper/956f1v1psmdx7",
  "venue": "Annals of medicine and surgery (2012)",
  "versions": []
}