{
  "abstract": "Skeletal editing enables precise structural modifications of molecules at late stages of a synthetic sequence, with applications in drug discovery and materials science. We recently demonstrated skeletal editing on the single-molecule scale. Voltage pulses applied by the tip of a scanning probe microscope to an oxygen-containing seven-membered heterocycle led to both oxygen deletion and ring-contraction rearrangement reactions. An open question is whether selective skeletal editing of a heterocyclic core can be achieved by an appropriate choice of the heteroatom. Here, we show that tip-induced reactions of an analogous sulfur-containing seven-membered ring results in sulfur deletion in virtually all cases. Our results demonstrate that the combination of tip-induced chemistry and heteroatom selection in the molecular design is a powerful strategy for single-molecule skeletal editing, with the potential to enable diverse structural transformations of heterocyclic frameworks.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": "2606.22677",
  "author_total": 8,
  "authors": [
    {
      "name": "Shantanu Mishra"
    },
    {
      "name": "Rasmus Svensson"
    },
    {
      "name": "Valentina Malave"
    },
    {
      "name": "Florian Albrecht"
    },
    {
      "name": "Manuel Vilas-Varela"
    },
    {
      "name": "Henrik Grönbeck"
    },
    {
      "name": "Leo Gross"
    },
    {
      "name": "Diego Peña"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/956yxmzp01npv.bib",
  "cited_by": 0,
  "doi": "10.48550/arxiv.2606.22677",
  "fulltext_url": null,
  "id": "956yxmzp01npv",
  "issns": [],
  "landing_url": "https://arxiv.org/abs/2606.22677",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "http://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": "CC0-1.0",
  "native_subjects": [
    [
      "arxiv",
      "cond-mat.mes-hall"
    ]
  ],
  "openalex": null,
  "pdf_url": "https://arxiv.org/pdf/2606.22677",
  "pmcid": null,
  "pmid": null,
  "published": "2026-06-21",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/956yxmzp01npv.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:26:45Z",
      "native_id": "2606.22677",
      "source": "arxiv",
      "url": "https://arxiv.org/abs/2606.22677"
    }
  ],
  "subjects": [
    {
      "field": "physics",
      "origin": "arxiv:cond-mat.mes-hall",
      "subfield": "condensed-matter"
    }
  ],
  "title": "Selectivity in tip-induced skeletal editing via heteroatom substitution",
  "title_text": "Selectivity in tip-induced skeletal editing via heteroatom substitution",
  "type": "preprint",
  "updated_at": "2026-10-30T12:26:45Z",
  "url": "https://research.draconitic.com/paper/956yxmzp01npv",
  "venue": "arXiv",
  "versions": [
    {
      "doi": "10.1021/jacs.6c12567",
      "pid": null,
      "relation": "published-as",
      "title": null,
      "venue": null
    }
  ]
}