{
  "abstract": "Aryl-substituted azetidines are found in pharmacologically active compounds; however, efficient synthetic methods to access this scaffold remain limited. Existing approaches predominantly enable the synthesis of azetidines bearing electron-rich aryl substituents. Herein, we report a new and straightforward route to 3-substituted 1-azabicyclo[1.1.0]-butanes (ABBs) from commercially available tert-butyl 3-oxoazetidine-1-carboxylate in four steps. The ABBs were then applied in a three-component photocatalytic ring-opening reaction, affording 3,3-diaryl-N-sulfonylazetidines with a variety of electron-poor (hetero)-arene units, a previously inaccessible chemical space. Under the optimized conditions, 29 examples of 3,3-diaryl-N-sulfonylazetidines were prepared in yields of up to 72%.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Chemistry, Johannes Gutenberg-University, Duesbergweg 10-14, Mainz 55128, Germany.",
    "Centre of Excellence for Research in Sustainable Chemistry, Department of Chemistry, Federal University of São Carlos, São Carlos 13565-905, Brazil."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Lucas G Furniel",
      "orcid": "0000-0003-1280-1449"
    },
    {
      "affs": [
        0
      ],
      "name": "Niklas Ehlenz"
    },
    {
      "affs": [
        0
      ],
      "name": "Dieter Schollmeyer"
    },
    {
      "affs": [
        1
      ],
      "name": "Arlene G Corrêa",
      "orcid": "0000-0003-4247-2228"
    },
    {
      "affs": [
        0
      ],
      "name": "Till Opatz",
      "orcid": "0000-0002-3266-4050"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/95hqfhgv15j35.bib",
  "cited_by": 1,
  "doi": "10.1021/jacsau.6c01100",
  "fulltext_url": "https://europepmc.org/articles/PMC13714842",
  "id": "95hqfhgv15j35",
  "issns": [
    "2691-3704"
  ],
  "landing_url": "https://europepmc.org/article/MED/42953189",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Article"
    ],
    [
      "openalex",
      "1605|Synthesis of β-Lactam Compounds"
    ]
  ],
  "openalex": "W7211886407",
  "pdf_url": "https://europepmc.org/articles/PMC13714842?pdf=render",
  "pmcid": "PMC13714842",
  "pmid": "42953189",
  "published": "2026-09-07",
  "publisher": "American Chemical Society",
  "ris": "https://research.draconitic.com/paper/95hqfhgv15j35.ris",
  "sources": [
    {
      "first_seen": "2026-10-31T00:20:41Z",
      "native_id": "MED:42953189",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42953189"
    },
    {
      "first_seen": "2026-11-01T12:22:15Z",
      "native_id": "PMC13714842",
      "source": "pmc",
      "url": "https://doi.org/10.1021/jacsau.6c01100"
    }
  ],
  "subjects": [
    {
      "field": "chemistry",
      "origin": "openalex:1605|Synthesis of β-Lactam Compounds",
      "subfield": "organic"
    }
  ],
  "title": "Synthesis and Photocatalytic Three-Component Ring-Opening of 3‑Substituted-1-azabicyclo[1.1.0]butanes toward 3,3-Disubstituted N‑Sulfonylazetidines.",
  "title_text": "Synthesis and Photocatalytic Three-Component Ring-Opening of 3‑Substituted-1-azabicyclo[1.1.0]butanes toward 3,3-Disubstituted N‑Sulfonylazetidines.",
  "type": "peer-reviewed",
  "updated_at": "2026-11-01T12:22:15Z",
  "url": "https://research.draconitic.com/paper/95hqfhgv15j35",
  "venue": "JACS Au",
  "versions": []
}