{
  "abstract": "OBJECTIVES: The objective is to investigate the association between antidepressant drugs intake and falls reporting, as well as the potential mediators in-between, in older adults. METHODS: In VigiBase®, the World Health Organization's pharmacovigilance database, we performed a disproportionality analysis to probe the putative associations between each antidepressant drugs class (non-selective monoamine reuptake inhibitors [NSMRIs], selective serotonin reuptake inhibitors [SSRIs], serotonin-norepinephrine reuptake inhibitors [SNRIs], alpha-2-adrenergic receptor antagonists, and \"other antidepressants\") and reports of falls in people aged 65 and over (NCT05628467). The reporting odds ratios and their 95% confidence interval were derived from logistic regression models with adjustment for confounders. We studied the falls-inducing mechanisms (delirium, hyponatremia, hypotension) by using causal mediation analyses and by using a disproportionality analysis for the co-occurrence of falls and these events. RESULTS: Our main analysis included 86,200 cases of falls reporting in older adults (of which 57% were 75 and over). A significant association was found between falls and every antidepressant drugs class, except for NSMRIs. According to causal mediation analysis, a direct effect on the falls reports was shown for alpha-2-adrenergic receptor antagonists and for \"other antidepressants\". According to the co-reports analyses, all antidepressant drugs classes except SNRIs were associated with the co-event fall-delirium; SSRIs, alpha-2-adrenergic receptor antagonists, and \"other antidepressants\" with fall-hypotension; all antidepressant drugs classes except NSMRIs with fall-hyponatremia. CONCLUSIONS: In multivariate disproportionality analyses, all antidepressant drugs classes were associated with signals of disproportionate reporting of falls in older adults, except for NSMRIs. In mediation analyses, a direct effect on the falls reports was only found for alpha-2-adrenergic receptor antagonists. Single-mediators based models seem insufficient to explain the diversity of clinical settings resulting in falls. These findings underline the necessity of a comprehensive analysis of all clinical and pharmacological features in older falling adults treated with antidepressant drugs.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 10,
  "authors": [
    {
      "name": "Elise-Marie Minoc"
    },
    {
      "name": "Cédric Villain"
    },
    {
      "name": "Basile Chrétien"
    },
    {
      "name": "Soumia Benbrika"
    },
    {
      "name": "Marie Heraudeau"
    },
    {
      "name": "Claire Lafont"
    },
    {
      "name": "Clémence Béchade"
    },
    {
      "name": "Thierry Lobbedez"
    },
    {
      "name": "Véronique Lelong-Boulouard"
    },
    {
      "name": "Charles Dolladille"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/95t2161wc7934.bib",
  "cited_by": 1,
  "doi": "10.1016/j.therap.2025.01.004",
  "fulltext_url": null,
  "id": "95t2161wc7934",
  "issns": [
    "0040-5957",
    "1958-5578"
  ],
  "landing_url": "https://hal.science/hal-05746268v1",
  "language": "en",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "hal",
      "0.sdv"
    ],
    [
      "hal",
      "0.shs"
    ],
    [
      "openalex",
      "3005|Pharmacovigilance and Adverse Drug Reactions"
    ]
  ],
  "openalex": "W4407121989",
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-09-11",
  "publisher": "Elsevier Masson",
  "ris": "https://research.draconitic.com/paper/95t2161wc7934.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:33Z",
      "native_id": "hal-05746268",
      "source": "hal",
      "url": "https://hal.science/hal-05746268v1"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:3005|Pharmacovigilance and Adverse Drug Reactions",
      "subfield": "pharmacology-toxicology"
    }
  ],
  "title": "Association between antidepressant drugs and falls in older adults: A mediation analysis in the World Health Organization's pharmacovigilance database",
  "title_text": "Association between antidepressant drugs and falls in older adults: A mediation analysis in the World Health Organization's pharmacovigilance database",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:33Z",
  "url": "https://research.draconitic.com/paper/95t2161wc7934",
  "venue": "Therapies",
  "versions": []
}