{
  "abstract": "A new synthetic strategy for the functionalization of the 1,8-naphthalimide core with weak nucleophiles was developed and is presented herein. By selection of the appropriate base and reaction temperature, access to difluoro, dialkoxy (including with a fused dioxa ring), and mixed fluoro-alkoky and alkoxy-hydroxy derivatives was achieved. All of the reactions proceed rapidly on a gram scale, affording the target products in a high yield (80–97%) and purity from inexpensive, commercially available starting compounds and reagents.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 10,
  "authors": [
    {
      "name": "Monika Mutovska"
    },
    {
      "name": "Konstantin Konstantinov"
    },
    {
      "name": "Irena Zagranyarska"
    },
    {
      "name": "Darío Puchán Sánchez"
    },
    {
      "name": "Magali Allain"
    },
    {
      "name": "Arthur David"
    },
    {
      "name": "Silvia Angelova"
    },
    {
      "name": "Stanimir Stoyanov"
    },
    {
      "name": "Clément Cabanetos"
    },
    {
      "name": "Yulian Zagranyarski"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/960bvebhb8g4w.bib",
  "cited_by": 0,
  "doi": "10.1021/acs.orglett.5c05282",
  "fulltext_url": null,
  "id": "960bvebhb8g4w",
  "issns": [
    "1523-7060",
    "1523-7052"
  ],
  "landing_url": "https://hal.science/hal-05698602v1",
  "language": "en",
  "licence": "CC-BY-NC-ND-4.0",
  "licence_label": "CC BY-NC-ND 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "hal",
      "0.chim"
    ],
    [
      "hal",
      "1.chim.orga"
    ],
    [
      "openalex",
      "3003|Fluorine in Organic Chemistry"
    ]
  ],
  "openalex": "W7125559403",
  "pdf_url": "https://hal.science/hal-05698602/document",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-08",
  "publisher": "American Chemical Society",
  "ris": "https://research.draconitic.com/paper/960bvebhb8g4w.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:51Z",
      "native_id": "hal-05698602",
      "source": "hal",
      "url": "https://hal.science/hal-05698602v1"
    }
  ],
  "subjects": [
    {
      "field": "chemistry",
      "origin": "hal:1.chim.orga",
      "subfield": "organic"
    }
  ],
  "title": "Functionalization of the 1,8-Naphthalimide Core with Weak Nucleophiles",
  "title_text": "Functionalization of the 1,8-Naphthalimide Core with Weak Nucleophiles",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:51Z",
  "url": "https://research.draconitic.com/paper/960bvebhb8g4w",
  "venue": "Organic Letters",
  "versions": []
}