{
  "abstract": "The exploration of zeolitic imidazolate framework (ZIF)-based nanoplatforms for drug delivery has attracted increasing attention in recent years. In this study, a bimetallic ZIF (BZIF) containing Zn and Co was synthesized through a simple one-pot approach under mild conditions. The formation of BZIF was confirmed through comprehensive physicochemical characterization. Curcumin (CUR) was subsequently loaded onto BZIF to obtain the CBZIF nanoplatform. CBZIF exhibited pH-responsive CUR release, with cumulative release reaching 78.19% at pH 5.5 compared with 44.25% at pH 7.4 after 72 h. In vitro studies demonstrated that CBZIF maintained favorable biocompatibility toward normal L929 cells while exhibiting enhanced anticancer activity against C26 cancer cells compared with free CUR and pristine BZIF. Overall, these findings suggest that CBZIF is a promising nanoplatform for pH-responsive CUR delivery and provide a basis for further investigation of its potential biomedical applications.",
  "abstract_shown": true,
  "affiliations": [
    "Institute of Advanced Technology, Vietnam Academy of Science and Technology 1B TL29 Street, An Phu Dong Ward Ho Chi Minh City 700000 Vietnam nguyenminhluan.work@gmail.com nguyendaihai0511@gmail.com.",
    "Graduate University of Science and Technology, Vietnam Academy of Science and Technology 18 Hoang Quoc Viet Street, Nghia Do Ward Hanoi City 100000 Vietnam.",
    "School of Biomedical Engineering, International University Ho Chi Minh City 700000 Vietnam.",
    "Vietnam National University Ho Chi Minh City Ho Chi Minh City 700000 Vietnam."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 7,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Luan Minh Nguyen",
      "orcid": "0000-0003-3981-2084"
    },
    {
      "affs": [
        0
      ],
      "name": "Giao Thuy Quynh Vu",
      "orcid": "0009-0006-9047-9706"
    },
    {
      "affs": [
        0
      ],
      "name": "Tan Phat Nguyen",
      "orcid": "0000-0001-9672-2785"
    },
    {
      "affs": [
        0
      ],
      "name": "Manh Hoang Tran",
      "orcid": "0000-0001-6862-2381"
    },
    {
      "affs": [
        0
      ],
      "name": "Thi My Huyen Nguyen",
      "orcid": "0000-0003-2804-2635"
    },
    {
      "affs": [
        2,
        3
      ],
      "name": "Long Binh Vong",
      "orcid": "0000-0002-2117-4312"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Dai Hai Nguyen",
      "orcid": "0000-0003-3501-7390"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/960q9gfnkfm7v.bib",
  "cited_by": 0,
  "doi": "10.1039/d6ra08606c",
  "fulltext_url": "https://europepmc.org/articles/PMC13678591",
  "id": "960q9gfnkfm7v",
  "issns": [
    "2046-2069"
  ],
  "landing_url": "https://europepmc.org/article/MED/42898706",
  "language": "eng",
  "licence": "CC-BY-NC",
  "licence_label": "CC BY-NC",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Chemistry"
    ],
    [
      "lcc",
      "QD1-999"
    ],
    [
      "openalex",
      "1313|Curcumin's Biomedical Applications"
    ]
  ],
  "openalex": "W7222971828",
  "pdf_url": "https://europepmc.org/articles/PMC13678591?pdf=render",
  "pmcid": "PMC13678591",
  "pmid": "42898706",
  "published": "2026-10-01",
  "publisher": "The Royal Society of Chemistry",
  "ris": "https://research.draconitic.com/paper/960q9gfnkfm7v.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:32Z",
      "native_id": "MED:42898706",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42898706"
    },
    {
      "first_seen": "2026-11-05T14:21:06Z",
      "native_id": "05bff6d0aeff4b12b29cc7f3b687af70",
      "source": "doaj",
      "url": "https://doi.org/10.1039/d6ra08606c"
    },
    {
      "first_seen": "2026-11-07T12:23:33Z",
      "native_id": "PMC13678591",
      "source": "pmc",
      "url": "https://doi.org/10.1039/d6ra08606c"
    }
  ],
  "subjects": [
    {
      "field": "chemistry",
      "origin": "heading:Chemistry",
      "subfield": "general"
    }
  ],
  "title": "Bimetallic ZIF nanoplatform for pH-responsive curcumin delivery: synthesis, characterization, and in vitro evaluation.",
  "title_text": "Bimetallic ZIF nanoplatform for pH-responsive curcumin delivery: synthesis, characterization, and in vitro evaluation.",
  "type": "peer-reviewed",
  "updated_at": "2026-11-08T12:21:02Z",
  "url": "https://research.draconitic.com/paper/960q9gfnkfm7v",
  "venue": "RSC advances",
  "versions": []
}