{
  "abstract": "Psoriasis is a chronic inflammatory skin disease associated with systemic metabolic dysregulation; however, the molecular pathways linking metabolic signaling to skin inflammation remain poorly understood. Here, we identify cannabinoid 1 receptor (CB1R) in macrophages as a key immunometabolic regulator of psoriatic inflammation and a potential therapeutic target. CB1R expression was increased in macrophages infiltrating psoriatic lesional skin in both humans and mice, and both pharmacological inhibition and genetic deletion of CB1R markedly attenuated psoriasis-like pathology in mouse models by reducing epidermal hyperplasia, inflammation, and barrier dysfunction in a macrophage-dependent manner. Mechanistically, CB1R signaling in macrophages suppressed expression of the RNA-binding protein AUF1, leading to stabilization of Nlrp3 mRNA and enhanced NLRP3 inflammasome activation. AUF1 directly bound an AU-rich region within the Nlrp3 3' untranslated region and promoted mRNA destabilization, thereby limiting inflammasome activation and IL-1β production. Restoration of AUF1 expression, either by CB1R inhibition or overexpression, reduced NLRP3 levels and alleviated psoriasis-like pathology, whereas Nlrp3 deficiency abrogated these effects. Collectively, these findings define a CB1R-AUF1-NLRP3 signaling axis that links metabolic signaling to inflammasome-driven skin inflammation in macrophages. Targeting macrophage CB1R may therefore represent a promising therapeutic strategy for psoriasis and other immunometabolic inflammatory diseases.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Molecular Science & Technology, Ajou University, Suwon, Republic of Korea.",
    "Department of Medical Science, Graduate School, The Catholic University of Korea, Seoul, Republic of Korea.",
    "Department of Life Science, Chung-Ang University, Seoul, Republic of Korea.",
    "Advanced College of Bio-Convergence Engineering, Ajou University, Suwon, Republic of Korea.",
    "Department of Dermatology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.",
    "National Institute on Aging, National Institutes of Health, Baltimore, Maryland, USA.",
    "Department of Biochemistry, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 23,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Hongseo Choi",
      "orcid": "0000-0003-4639-5995"
    },
    {
      "affs": [
        1
      ],
      "name": "Sukyoung Han",
      "orcid": "0009-0004-0284-7093"
    },
    {
      "affs": [
        2
      ],
      "name": "Jinho Kim"
    },
    {
      "affs": [
        0
      ],
      "name": "Ji Hye Han",
      "orcid": "0009-0001-7204-8682"
    },
    {
      "affs": [
        0
      ],
      "name": "Eunsu Kim"
    },
    {
      "affs": [
        0
      ],
      "name": "Yeonjeong Heo"
    },
    {
      "affs": [
        0
      ],
      "name": "Minju Lee",
      "orcid": "0009-0002-0417-3489"
    },
    {
      "affs": [
        0
      ],
      "name": "Jooyoung Lee"
    },
    {
      "affs": [
        0
      ],
      "name": "Heerim You"
    },
    {
      "affs": [
        0
      ],
      "name": "Soyoun Lee"
    },
    {
      "affs": [
        0
      ],
      "name": "Su-Hee Han"
    },
    {
      "affs": [
        0
      ],
      "name": "Ilrok Yoon"
    },
    {
      "affs": [
        0
      ],
      "name": "Sung Anjeon"
    },
    {
      "affs": [
        0
      ],
      "name": "Hyerim Kang"
    },
    {
      "affs": [
        1
      ],
      "name": "Seungyeon Ryu"
    },
    {
      "affs": [
        0,
        3
      ],
      "name": "Hyun-Ji Park",
      "orcid": "0000-0001-9688-4418"
    },
    {
      "affs": [
        0,
        3
      ],
      "name": "Eunha Kim",
      "orcid": "0000-0002-0766-696X"
    },
    {
      "affs": [
        4
      ],
      "name": "Chul Hwan Bang"
    },
    {
      "affs": [
        4
      ],
      "name": "Ji Hyun Lee",
      "orcid": "0000-0002-3671-502X"
    },
    {
      "affs": [
        5
      ],
      "name": "Josephine M Egan"
    },
    {
      "affs": [
        2
      ],
      "name": "Jung-Woong Kim",
      "orcid": "0000-0003-4458-7213"
    },
    {
      "affs": [
        1,
        6
      ],
      "name": "Eun Kyung Lee",
      "orcid": "0000-0003-4207-2080"
    },
    {
      "affs": [
        0,
        3
      ],
      "name": "Wook Kim",
      "orcid": "0000-0002-7701-4684"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/9614bfhmjkzba.bib",
  "cited_by": 0,
  "doi": "10.1002/advs.78313",
  "fulltext_url": "https://europepmc.org/articles/PMC13669225",
  "id": "9614bfhmjkzba",
  "issns": [
    "2198-3844"
  ],
  "landing_url": "https://europepmc.org/article/MED/42875876",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2403|Psoriasis: Treatment and Pathogenesis"
    ]
  ],
  "openalex": "W7222325033",
  "pdf_url": "https://europepmc.org/articles/PMC13669225?pdf=render",
  "pmcid": "PMC13669225",
  "pmid": "42875876",
  "published": "2026-10-14",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/9614bfhmjkzba.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:18:46Z",
      "native_id": "MED:42875876",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42875876"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:2403|Psoriasis: Treatment and Pathogenesis",
      "subfield": "immunology"
    }
  ],
  "title": "Targeting Cannabinoid 1 Receptor in Macrophages Alleviates Psoriatic Skin Inflammation Through the AUF1-NLRP3 Axis.",
  "title_text": "Targeting Cannabinoid 1 Receptor in Macrophages Alleviates Psoriatic Skin Inflammation Through the AUF1-NLRP3 Axis.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:18:46Z",
  "url": "https://research.draconitic.com/paper/9614bfhmjkzba",
  "venue": "Advanced science (Weinheim, Baden-Wurttemberg, Germany)",
  "versions": []
}