{
  "abstract": "Background\n\nAlthough atopic dermatitis (AD) is associated with a decrease of filaggrin levels, the underlying mechanisms are not clearly understood. Here, we aimed to investigate the pathogenic roles of the splicing factor proline- and glutamine-rich (SFPQ)/S100 calcium-binding protein A8 (S100A8) complex, a critical regulator inducing filaggrin deficiency in AD.Methods\n\nThe formation of SFPQ/S100A8 complex was analyzed in the keratinocytes and skin tissues from patients with AD and 2,4-dinitrochlorobenzene (DNCB)-induced AD-like mice. The effects of leptomycin B, a CRM1 inhibitor, and rapamycin, a mTOR inhibitor were determined in DNCB-induced AD-like mice and the non-lesional and lesional primary keratinocytes of AD patients.Results\n\nThe relocation of SFPQ from the nucleus to the cytoplasm, elevated S100A8 levels, and SFPQ/S100A8 complex formation were proportional to filaggrin deficiency and AD severity in the keratinocytes of AD patients and AD-like mice. Interaction of the complex with filaggrin and c-Jun N-terminal kinase (JNK) accelerated filaggrin degradation via selective autophagy and filaggrin downregulation via JNK phosphorylation, respectively. The mechanistic target of rapamycin kinase (mTOR) and chromosomal region maintenance 1 (CRM1) facilitated the cytosolic export of SFPQ to form the complex in human keratinocytes. Administration of leptomycin B and rapamycin suppressed the decrease in filaggrin levels by inhibiting SFPQ/S100A8 complex formation in AD-like mice.Conclusions\n\nThis study demonstrates that the formation of SFPQ/S100A8 complex is a critical process in AD progression, which provides key insights into the pathogenic mechanisms of AD. The elucidation of the SFPQ/S100A8 complex axis in AD pathogenesis can be leveraged to develop therapeutic drugs for AD treatment.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Senior Healthcare, Graduate School, Eulji University, Uijeongbu, 11759, Republic of Korea.",
    "Department of Dermatology, Nowon Eulji Medical Center, Eulji University, Seoul, 01830, Republic of Korea.",
    "Department of Dermatology, Uijeongbu Eulji Medical Center, Eulji University, Uijeongbu, 11759, Republic of Korea.",
    "Department of Biomedical Laboratory Science, College of Health Science, Eulji University, Seongnam, 13135, Republic of Korea.",
    "Department of Biomedical Laboratory Science, Daegu Haany University, Gyeongsan, 38610, Republic of Korea.",
    "Department of Otorhinolaryngology-Head and Neck Surgery, Uijeongbu Eulji Medical Center, Eulji University, Uijeongbu, 11759, Republic of Korea.",
    "College of Pharmacy and Institute of Pharmaceutical Sciences, CHA University, Pocheon, 11160, Republic of Korea.",
    "Department of Biomedical Laboratory Science, College of Healthcare and Medical Sciences, Wonkwang University, Iksan, 54538, Republic of Korea. oliver73@wku.ac.kr.",
    "Department of Senior Healthcare, Graduate School, Eulji University, Uijeongbu, 11759, Republic of Korea. orientree@hanmail.net.",
    "Department of Biomedical Laboratory Science, College of Health Science, Eulji University, 712, Dongil-ro, Uijeongbu, 11759, Republic of Korea. orientree@hanmail.net."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 12,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Geunyeong Kim"
    },
    {
      "affs": [
        0
      ],
      "name": "Yujin Hong"
    },
    {
      "affs": [
        1
      ],
      "name": "Tae Young Han"
    },
    {
      "affs": [
        2
      ],
      "name": "Byeol Han"
    },
    {
      "affs": [
        3
      ],
      "name": "Beom Seok Park"
    },
    {
      "affs": [
        4
      ],
      "name": "Eun Ju Yang"
    },
    {
      "affs": [
        0
      ],
      "name": "Ayesha Kashif"
    },
    {
      "affs": [
        5
      ],
      "name": "Young Joon Jun"
    },
    {
      "affs": [
        6
      ],
      "name": "Hongchan An"
    },
    {
      "affs": [
        0
      ],
      "name": "Juram Lee"
    },
    {
      "affs": [
        7
      ],
      "name": "Ji Sook Lee"
    },
    {
      "affs": [
        8,
        9
      ],
      "name": "In Sik Kim"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/962s8kvnzc6ba.bib",
  "cited_by": 0,
  "doi": "10.1186/s12964-026-02776-5",
  "fulltext_url": "https://europepmc.org/articles/PMC13681959",
  "id": "962s8kvnzc6ba",
  "issns": [
    "1478-811X"
  ],
  "landing_url": "https://europepmc.org/article/MED/42897640",
  "language": "eng",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "lcc",
      "QH573-671"
    ],
    [
      "lcc",
      "R"
    ],
    [
      "openalex",
      "2708|Dermatology and Skin Diseases"
    ]
  ],
  "openalex": "W7170139328",
  "pdf_url": "https://europepmc.org/articles/PMC13681959?pdf=render",
  "pmcid": "PMC13681959",
  "pmid": "42897640",
  "published": "2026-07-01",
  "publisher": "BMC",
  "ris": "https://research.draconitic.com/paper/962s8kvnzc6ba.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:42Z",
      "native_id": "MED:42897640",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42897640"
    },
    {
      "first_seen": "2026-10-30T13:46:09Z",
      "native_id": "3dc722df59a84d63911f5216c7cb36a9",
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      "url": "https://doi.org/10.1186/s12964-026-02776-5"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "lcc:QH573-671",
      "subfield": "cell-biology"
    },
    {
      "field": "medicine",
      "origin": "lcc:R",
      "subfield": "general"
    }
  ],
  "title": "SFPQ/S100A8 complex induces filaggrin deficiency via selective autophagy and JNK phosphorylation in atopic dermatitis.",
  "title_text": "SFPQ/S100A8 complex induces filaggrin deficiency via selective autophagy and JNK phosphorylation in atopic dermatitis.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T13:46:09Z",
  "url": "https://research.draconitic.com/paper/962s8kvnzc6ba",
  "venue": "Cell communication and signaling : CCS",
  "versions": []
}