{
  "abstract": "Background\n\nPulmonary embolism (PE) is a potentially life-threatening diagnosis that commonly presents to the emergency department with nonspecific symptoms. Despite advances in diagnostic algorithms, rapid identification remains challenging, particularly when definitive imaging is delayed or unavailable. Simple and readily available biomarkers may assist in the early evaluation of patients with suspected PE. This study investigated the diagnostic value of the monocyte-to-large platelet ratio (MLPR), a novel inflammation- and thrombosis-related biomarker, in acute PE.Methods\n\nThis retrospective exploratory study reviewed 115 medical records of patients presenting with suspected PE to the emergency department between January and December 2024 who underwent computed tomography pulmonary angiography. After applying exclusion criteria, 53 patients were included (25 PE, 28 non-PE). Admission complete blood count parameters, including MLPR, monocyte and lymphocyte counts, and derived ratios, were analyzed.Results\n\nAge and sex distribution were similar between groups. Total leukocyte, monocyte, neutrophil, and lymphocyte counts were significantly higher in the PE group, alongside significantly elevated MLPR (1.19 ± 0.45 vs. 0.61 ± 0.39; P < 0.001), while NLR did not differ significantly (P = 0.4235). MLPR demonstrated the highest diagnostic performance among individual hematological markers (AUC 0.854, 95% CI 0.752-0.956; P < 0.001). Combining MLPR with lymphocyte count further improved diagnostic accuracy (AUC 0.907, 95% CI 0.827-0.986), achieving 92% sensitivity and 85.7% specificity.Conclusion\n\nMLPR is a promising, readily available biomarker for diagnosing acute PE, with enhanced performance when combined with lymphocyte count.",
  "abstract_shown": true,
  "affiliations": [
    "Division of Critical Care, Department of Anesthesia and Critical Care, Faculty of Medicine, Ain Shams University, Cairo, Egypt.",
    "Department of Anesthesia and Critical Care, Faculty of Medicine, Ain Shams University, Cairo, Egypt."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 4,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Mohamed K A Awad"
    },
    {
      "affs": [
        1
      ],
      "name": "Reem H El Kabarity"
    },
    {
      "affs": [
        1
      ],
      "name": "Hadeel Magdy Abdelhamid"
    },
    {
      "affs": [
        1
      ],
      "name": "Azza M Youssef"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/96a27qc2r0v40.bib",
  "cited_by": 0,
  "doi": "10.1016/j.ahjo.2026.100951",
  "fulltext_url": "https://europepmc.org/articles/PMC13692137",
  "id": "96a27qc2r0v40",
  "issns": [
    "2666-6022"
  ],
  "landing_url": "https://europepmc.org/article/MED/42921207",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2724|Venous Thromboembolism Diagnosis and Management"
    ]
  ],
  "openalex": "W7221706856",
  "pdf_url": "https://europepmc.org/articles/PMC13692137?pdf=render",
  "pmcid": "PMC13692137",
  "pmid": "42921207",
  "published": "2026-10-13",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/96a27qc2r0v40.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:20:33Z",
      "native_id": "MED:42921207",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42921207"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "journal-openalex:2705|Heart Failure Treatment and Management",
      "subfield": "cardiovascular"
    }
  ],
  "title": "Monocyte to large platelet ratio as a diagnostic marker for acute pulmonary embolism.",
  "title_text": "Monocyte to large platelet ratio as a diagnostic marker for acute pulmonary embolism.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:20:33Z",
  "url": "https://research.draconitic.com/paper/96a27qc2r0v40",
  "venue": "American heart journal plus : cardiology research and practice",
  "versions": []
}