{
  "abstract": "Rotavirus vaccines reduce severe gastroenteritis, but reassortment and the emergence of animal-like strains raise concerns about vaccine mismatch. We analyzed hospital-based surveillance in Taiwan during 2005–2017, integrating VP7/VP4 genotyping, whole-genome sequencing (WGS), and a test-negative vaccine-effectiveness study during 2014–2017. Rotavirus positivity among hospitalized children with acute gastroenteritis declined from 25.6% in 2005–2007 to 18.4% in 2008–2011 and 10.3% in 2014–2017, while the detection of G3P[8] strains increased in the late-vaccine period. By 2014, equine-like VP7 G3P[8] viruses had largely replaced previously circulating typical human Wa-like G3P[8] strains; 271/276 G3P[8] detections were equine-like. Whole-genome sequencing of a subset yielded 132 near-complete genomes overall, including 61 G3P[8] genomes; all G3P[8] genomes sequenced from 2005 to 2011 were Wa-like, whereas 37 of 40 sequenced post-2014 G3P[8] genomes had DS-1-like backbones. In the 2014–2017 test-negative vaccine-effectiveness analysis, unconditional logistic regression controlling for age in months, hospital site, calendar year, and calendar month showed high protection against rotavirus-associated hospitalization for Rotarix (82.0%, 95% CI 75.9–86.6) and RotaTeq (90.1%, 95% CI 83.5–94.0). Vaccine effectiveness estimates restricted to WGS-confirmed G3P[8] DS-1-like cases were imprecise and exploratory. These data provide indirect epidemiologic evidence that protection against severe rotavirus hospitalization was maintained during the emergence of the dominant equine-like DS-1-like G3P[8] lineage.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "name": "Daniel E. Velasquez-Portocarrero",
      "orcid": "0000-0001-6520-5777"
    },
    {
      "name": "Kun-Lin Tsai"
    },
    {
      "name": "Ching-Yi Wu"
    },
    {
      "name": "Jacqueline Tate"
    },
    {
      "name": "Baoming Jiang",
      "orcid": "0000-0003-2072-0729"
    },
    {
      "name": "Fang-Tzy Wu",
      "orcid": "0000-0001-5448-677X"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/96entqq4t0zfm.bib",
  "cited_by": 0,
  "doi": "10.1038/s41598-026-73101-w",
  "fulltext_url": null,
  "id": "96entqq4t0zfm",
  "issns": [
    "2045-2322"
  ],
  "landing_url": "https://www.nature.com/articles/s41598-026-73101-w",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2725|Viral gastroenteritis research and epidemiology"
    ]
  ],
  "openalex": "W7214967552",
  "pdf_url": "https://www.nature.com/articles/s41598-026-73101-w_reference.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-09-30",
  "publisher": "Springer Science and Business Media LLC",
  "ris": "https://research.draconitic.com/paper/96entqq4t0zfm.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:19Z",
      "native_id": "10.1038/s41598-026-73101-w",
      "source": "crossref",
      "url": "https://www.nature.com/articles/s41598-026-73101-w"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2725|Viral gastroenteritis research and epidemiology",
      "subfield": "infectious-disease"
    }
  ],
  "title": "Genome-wide replacement by DS-1-like equine-like G3P[8] rotaviruses in Taiwan and implications for vaccine effectiveness",
  "title_text": "Genome-wide replacement by DS-1-like equine-like G3P[8] rotaviruses in Taiwan and implications for vaccine effectiveness",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:19Z",
  "url": "https://research.draconitic.com/paper/96entqq4t0zfm",
  "venue": "Scientific Reports",
  "versions": []
}