{
  "abstract": "Chemically resolved analysis of fragile biomolecular systems remains challenging because nanoscale spatial information must be obtained without compromising the mass-spectral clarity. Ferritin serves as an effective nanoscale model system featuring an organic protein shell surrounding an Fe-rich mineral core. Here, ferritin-containing hydrated specimens were prepared using graphene encapsulation and analyzed by THz-pulsed atom probe tomography. Compared with conventional laser-pulsing conditions, THz excitation improved peak definition and reduced spectral background, enabling detection of Fe-containing ions and isolation of an Fe-rich cluster consistent with the ferritin core. Although molecular overlaps and low ion counts still limit unambiguous peak assignment, isotopic, spatial, and signal-quality analyses support the identification of an Fe-rich region within an organic environment with further improvements expected at increased electric field strength. These results demonstrate that terahertz-pulsed atom probe tomography substantially improves the chemical readability of hydrated biological materials, opening new perspectives for their nanoscale studies.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 11,
  "authors": [
    {
      "name": "Florant Exertier"
    },
    {
      "name": "Laurence Chevalier"
    },
    {
      "name": "Simona Moldovan"
    },
    {
      "name": "Leo Guiramand"
    },
    {
      "name": "Matteo de Tullio"
    },
    {
      "name": "Marc Ropitaux"
    },
    {
      "name": "Jonathan Houard"
    },
    {
      "name": "Linda Barbieri"
    },
    {
      "name": "Davide Prosperi"
    },
    {
      "name": "Ammar Hideur"
    },
    {
      "name": "Angela Vella"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/96pt39hf37j25.bib",
  "cited_by": 0,
  "doi": "10.1021/acs.nanolett.6c03708",
  "fulltext_url": null,
  "id": "96pt39hf37j25",
  "issns": [
    "1530-6984",
    "1530-6992"
  ],
  "landing_url": "https://hal.science/hal-05853235v1",
  "language": "en",
  "licence": "CC-BY-NC-ND-4.0",
  "licence_label": "CC BY-NC-ND 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "hal",
      "0.phys"
    ],
    [
      "hal",
      "1.phys.cond"
    ],
    [
      "hal",
      "2.phys.cond.cm-ms"
    ],
    [
      "openalex",
      "2204|Advanced Materials Characterization Techniques"
    ]
  ],
  "openalex": "W7225265816",
  "pdf_url": "https://hal.science/hal-05853235/document",
  "pmcid": null,
  "pmid": null,
  "published": "2026-11-04",
  "publisher": "American Chemical Society",
  "ris": "https://research.draconitic.com/paper/96pt39hf37j25.ris",
  "sources": [
    {
      "first_seen": "2026-11-06T12:20:44Z",
      "native_id": "hal-05853235",
      "source": "hal",
      "url": "https://hal.science/hal-05853235v1"
    }
  ],
  "subjects": [
    {
      "field": "physics",
      "origin": "hal:1.phys.cond",
      "subfield": "condensed-matter"
    }
  ],
  "title": "Toward Nanoscale Chemical Clarity: THz-Pulsed Atom Probe Tomography for Hydrated Biological Materials",
  "title_text": "Toward Nanoscale Chemical Clarity: THz-Pulsed Atom Probe Tomography for Hydrated Biological Materials",
  "type": "peer-reviewed",
  "updated_at": "2026-11-07T12:20:25Z",
  "url": "https://research.draconitic.com/paper/96pt39hf37j25",
  "venue": "Nano Letters",
  "versions": []
}