{
  "abstract": "Mitochondria regulate intracellular Ca2+ by uptake through the mitochondrial Ca2+ uniporter (MCU) and release via the mitochondrial permeability transition pore (mPTP). In astrocytes, neurotransmitter stimulation evokes Ca2+ signaling, yet the role of mitochondria in shaping these responses remains unclear. We extended a compartmental astrocyte model developed by our group to include MCU- and mPTP-mediated dynamics, and simulated glutamatergic and dopaminergic inputs modeled as Poisson processes driving IP3 synthesis through the phospholipase-C (PLC) pathway. Both unipolar and bifurcated-terminal morphologies were considered, with mitochondria positioned in alternating compartments starting from the soma; distal compartments contained mitochondria only when sufficiently large. Simulations show that mitochondria modulate Ca2+ signaling in a context-dependent manner: under weak glutamatergic input, they reduce oscillation frequency and limit signal propagation, whereas under strong glutamatergic input or dopaminergic modulation, they enhance Ca2+ responses by reducing Ca2+-dependent IP3 degradation. These results suggest that mitochondria can play an important role in shaping the spatial organization of Ca2+ signaling in astrocytes.\n\nSupplementary Information: The online version contains supplementary material available at https://doi.org/10.1007/s10827-026-00956-3.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Physics, School of Philosophy, Sciences and Letters of Ribeirão Preto, University of São Paulo, Bandeirantes avenue, Ribeirão Preto, 14040-900 São Paulo Brazil"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 2,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Thiago Ohno Bezerra"
    },
    {
      "affs": [
        0
      ],
      "name": "Antonio C. Roque"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/96tdh6aa0bjgt.bib",
  "cited_by": 0,
  "doi": "10.1007/s10827-026-00956-3",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13710611/",
  "id": "96tdh6aa0bjgt",
  "issns": [
    "0929-5313",
    "1573-6873"
  ],
  "landing_url": "https://doi.org/10.1007/s10827-026-00956-3",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Research"
    ],
    [
      "openalex",
      "1312|Mitochondrial Function and Pathology"
    ]
  ],
  "openalex": "W7214277770",
  "pdf_url": "https://link.springer.com/content/pdf/10.1007/s10827-026-00956-3.pdf",
  "pmcid": "PMC13710611",
  "pmid": "42789229",
  "published": "2026-09-25",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/96tdh6aa0bjgt.ris",
  "sources": [
    {
      "first_seen": "2026-10-31T12:21:32Z",
      "native_id": "PMC13710611",
      "source": "pmc",
      "url": "https://doi.org/10.1007/s10827-026-00956-3"
    }
  ],
  "subjects": [
    {
      "field": "biochemistry",
      "origin": "openalex:1312|Mitochondrial Function and Pathology",
      "subfield": "molecular-biology"
    }
  ],
  "title": "Context-Dependent modulation of astrocytic Ca2+ signals by mitochondria: a computational study",
  "title_text": "Context-Dependent modulation of astrocytic Ca2+ signals by mitochondria: a computational study",
  "type": "peer-reviewed",
  "updated_at": "2026-10-31T12:21:32Z",
  "url": "https://research.draconitic.com/paper/96tdh6aa0bjgt",
  "venue": "Journal of Computational Neuroscience",
  "versions": []
}