{
  "abstract": "Fungal keratitis is a potentially vision-threatening infection that can be difficult to treat when it involves the deep corneal layers. We report the case of a 50-year-old woman who developed deep central fungal keratitis following vegetative ocular trauma. Microbiological analysis identified Aspergillus flavus (A. flavus). Despite intensive topical treatment with voriconazole 1% and amphotericin B 0.15%, the infiltrate progressed after one week. A single intrastromal injection of voriconazole (50 µg/0.1 mL) was administered circumferentially around the infiltrate. Progressive clinical improvement followed, with complete resolution within one month and no recurrence during two years of follow-up. Final visual acuity was 20/100, with residual corneal scarring. This case highlights the potential role of intrastromal voriconazole as a targeted treatment option for deep, refractory fungal keratitis.",
  "abstract_shown": true,
  "affiliations": [
    "Adult Ophthalmology Department, Faculty of Medicine and Pharmacy of Casablanca, 20 August 1953 Hospital, Ibn Rochd University Hospital Center, Hassan II University, Casablanca, MAR."
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Kaoutar Fahmaoui"
    },
    {
      "affs": [
        0
      ],
      "name": "Achraf Aneddame"
    },
    {
      "affs": [
        0
      ],
      "name": "Adil Mchachi"
    },
    {
      "affs": [
        0
      ],
      "name": "Laila Benhmidoune"
    },
    {
      "affs": [
        0
      ],
      "name": "Rachid Rayad"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/972kxrasnsmnq.bib",
  "cited_by": 0,
  "doi": "10.7759/cureus.116869",
  "fulltext_url": "https://europepmc.org/articles/PMC13695504",
  "id": "972kxrasnsmnq",
  "issns": [
    "2168-8184"
  ],
  "landing_url": "https://europepmc.org/article/MED/42927403",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2731|Ocular Infections and Treatments"
    ]
  ],
  "openalex": "W7214150698",
  "pdf_url": "https://europepmc.org/articles/PMC13695504?pdf=render",
  "pmcid": "PMC13695504",
  "pmid": "42927403",
  "published": "2026-09-24",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/972kxrasnsmnq.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:21:18Z",
      "native_id": "MED:42927403",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42927403"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2731|Ocular Infections and Treatments",
      "subfield": "general"
    }
  ],
  "title": "Single Intrastromal Voriconazole Injection for Refractory Aspergillus flavus Keratitis.",
  "title_text": "Single Intrastromal Voriconazole Injection for Refractory Aspergillus flavus Keratitis.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:21:18Z",
  "url": "https://research.draconitic.com/paper/972kxrasnsmnq",
  "venue": "Cureus",
  "versions": []
}