{
  "abstract": "Background\n\nPatients with chronic kidney disease (CKD) may be vulnerable to thiamine insufficiency due to dietary restrictions, altered metabolism, and renal replacement therapy. We aimed to determine the prevalence of functional thiamine deficiency, its distribution across CKD stages, and the associated clinical factors in a Thai population.Areas covered\n\nThiamine status was assessed in red blood cells using the erythrocyte transketolase activity coefficient (ETKAC) assay. Participants (n = 605) were categorized as having normal thiamine status (ETKAC ≤1.25) or functional thiamine deficiency (ETKAC >1.25). The prevalence of functional thiamine deficiency was 6.1% overall and 6.4% among participants with CKD. Univariate analyses of participants with CKD showed that higher systolic blood pressure (SBP), hypertension, and lower estimated glomerular filtration rate (eGFR) were associated with functional thiamine deficiency. In the multivariable analysis adjusted for age, sex, SBP, eGFR, and alcohol intake, hypertension remained independently associated with functional thiamine deficiency (β = 2.202; 95% confidence interval (CI) for the corresponding odds ratio (OR): 2.311-35.383; p = 0.002).Expert opinion/commentary\n\nFunctional thiamine deficiency was observed in a subset of participants, particularly in patients with CKD and hypertension, supporting further investigation of thiamine status in CKD populations.",
  "abstract_shown": true,
  "affiliations": [
    "Research and Innovation Affairs, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.",
    "Chronic Kidney Disease Prevention in the Northeast of Thailand (CKDNET), Khon Kaen University, Khon Kaen, Thailand.",
    "Department of Biochemistry, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.",
    "The Centre for Research and Development of Medical Diagnostic Laboratories, Faculty of Associated Medical Sciences, Khon Kaen University, Khon Kaen, Thailand.",
    "Faculty of Public Health, Khon Kaen University, Khon Kaen, Thailand.",
    "Department of Medical Technology, Faculty of Associated Medical Sciences, Khon Kaen University, Khon Kaen, Thailand.",
    "Department of Internal Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 10,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Kanokwan Nahok"
    },
    {
      "affs": [
        1,
        2
      ],
      "name": "Chalongchai Chalermwat"
    },
    {
      "affs": [
        1,
        2
      ],
      "name": "Ubon Cha'on",
      "orcid": "0000-0002-9909-8671"
    },
    {
      "affs": [
        1,
        3
      ],
      "name": "Apinya Jusakul",
      "orcid": "0000-0001-7652-7771"
    },
    {
      "affs": [
        2
      ],
      "name": "Patcharee Boonsiri",
      "orcid": "0000-0003-0855-1440"
    },
    {
      "affs": [
        2
      ],
      "name": "Angkor Chamdam"
    },
    {
      "affs": [
        1,
        4
      ],
      "name": "Ratthaphol Kraiklang",
      "orcid": "0000-0002-1860-4510"
    },
    {
      "affs": [
        1,
        5
      ],
      "name": "Patcharaporn Tippayawat",
      "orcid": "0000-0002-4452-1284"
    },
    {
      "affs": [
        1,
        6
      ],
      "name": "Sirirat Anutrakulchai",
      "orcid": "0000-0003-1706-4863"
    },
    {
      "affs": [
        1,
        2
      ],
      "name": "Worachart Lert-Itthiporn",
      "orcid": "0000-0002-7223-0169"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/97k428kwc87sa.bib",
  "cited_by": 0,
  "doi": "10.1080/20565623.2026.2738750",
  "fulltext_url": "https://europepmc.org/articles/PMC13656806",
  "id": "97k428kwc87sa",
  "issns": [
    "2056-5623"
  ],
  "landing_url": "https://europepmc.org/article/MED/42852733",
  "language": "eng",
  "licence": "CC-BY-NC",
  "licence_label": "CC BY-NC",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2728|Alcoholism and Thiamine Deficiency"
    ]
  ],
  "openalex": "W7221187231",
  "pdf_url": "https://europepmc.org/articles/PMC13656806?pdf=render",
  "pmcid": "PMC13656806",
  "pmid": "42852733",
  "published": "2026-10-09",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/97k428kwc87sa.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:18:02Z",
      "native_id": "MED:42852733",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42852733"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2728|Alcoholism and Thiamine Deficiency",
      "subfield": "neurology"
    }
  ],
  "title": "Functional thiamine deficiency in patients with chronic kidney disease in Northeast Thailand.",
  "title_text": "Functional thiamine deficiency in patients with chronic kidney disease in Northeast Thailand.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:18:02Z",
  "url": "https://research.draconitic.com/paper/97k428kwc87sa",
  "venue": "Future science OA",
  "versions": []
}