{
  "abstract": "Osteoarthritis (OA) is a chronic, degenerative disease affecting joint tissue. Resveratrol (RES), a natural polyphenolic compound, has anti-inflammatory, antioxidant and anti-apoptotic effects in chondrocytes and macrophages, suggesting therapeutic potential for OA. The present study investigated the molecular mechanisms of RES in OA treatment through network pharmacology analysis and in vitro and in vivo experiments. Network pharmacology was performed to identify potential therapeutic targets and pathways. An OA cell model was established by treating SW1353 cells with IL-1β, followed by RES intervention without or with AMPK inhibitor to evaluate the effects on the AMPK/PPARγ signaling pathway, NLRP3 inflammasome response, and extracellular matrix (ECM) metabolism. For in vivo assays, OA mice were established through the destabilization of the medial meniscus (DMM) surgery, and administered RES through oral gavage. Histopathological changes, serum inflammatory factors and the expression of target proteins in articular cartilage were analyzed. Network pharmacology identified the AMPK/PPARγ pathway as a key mechanism underlying the therapeutic effects of RES in OA. In vitro, RES activated the AMPK/PPARγ pathway and inhibited the NLRP3 inflammasome response, thereby preserving ECM homeostasis in SW1353 cells. In vivo, RES alleviated OA progression by suppressing cartilage degeneration and synovitis, and regulating serum inflammatory levels. The target protein changes were consistent with the in vitro findings. The present study demonstrates that RES effectively regulates the NLRP3 inflammasome response by activating the AMPK/PPARγ signaling pathway, providing a valuable experimental foundation and potential clinical utility for RES as a complementary and alternative therapy for OA.",
  "abstract_shown": true,
  "affiliations": [
    "School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi 710018, P.R. China",
    "College of Medical Technology, Guiyang Kangyang University, Guiyang, Guizhou 550081, P.R. China",
    "Department of Joint Surgery, Translational Medicine Center, Honghui Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi 710054, P.R. China"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 8,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Shanshan Cui"
    },
    {
      "affs": [
        2
      ],
      "name": "Zifan Luo"
    },
    {
      "affs": [
        1
      ],
      "name": "Wen Qin"
    },
    {
      "affs": [
        2
      ],
      "name": "Bo Chen"
    },
    {
      "affs": [
        0
      ],
      "name": "Qiaoxia Zhang"
    },
    {
      "affs": [
        2
      ],
      "name": "Jianbing Ma"
    },
    {
      "affs": [
        0
      ],
      "name": "Jie Ma"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Rui Zhang"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/97ps81k2qpfrg.bib",
  "cited_by": 0,
  "doi": "10.3892/ijmm.2026.6015",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13712497/",
  "id": "97ps81k2qpfrg",
  "issns": [
    "1107-3756",
    "1791-244X"
  ],
  "landing_url": "https://doi.org/10.3892/ijmm.2026.6015",
  "language": "en",
  "licence": "CC-BY-NC-ND-4.0",
  "licence_label": "CC BY-NC-ND 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Articles"
    ],
    [
      "openalex",
      "2745|Osteoarthritis Treatment and Mechanisms"
    ]
  ],
  "openalex": "W7221761441",
  "pdf_url": "http://www.spandidos-publications.com/10.3892/ijmm.2026.6015/download",
  "pmcid": "PMC13712497",
  "pmid": "42885307",
  "published": "2026-10-14",
  "publisher": "Spandidos Publications",
  "ris": "https://research.draconitic.com/paper/97ps81k2qpfrg.ris",
  "sources": [
    {
      "first_seen": "2026-10-31T12:23:03Z",
      "native_id": "PMC13712497",
      "source": "pmc",
      "url": "https://doi.org/10.3892/ijmm.2026.6015"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2745|Osteoarthritis Treatment and Mechanisms",
      "subfield": "general"
    }
  ],
  "title": "Resveratrol alleviates osteoarthritis progression by inhibiting NLRP3 inflammasome response via the AMPK/PPARγ signaling pathway",
  "title_text": "Resveratrol alleviates osteoarthritis progression by inhibiting NLRP3 inflammasome response via the AMPK/PPARγ signaling pathway",
  "type": "peer-reviewed",
  "updated_at": "2026-10-31T12:23:03Z",
  "url": "https://research.draconitic.com/paper/97ps81k2qpfrg",
  "venue": "International Journal of Molecular Medicine",
  "versions": []
}