{
  "abstract": "Plant yield is often maximized by the extensive use of mineral fertilizers, which, however, has severe environmental consequences. Phosphate is particularly problematic, as it represents a globally limited resource, and its runoff and soil erosion threaten open water bodies. Many crops engage in arbuscular mycorrhizal (AM) symbiosis with nutrient-acquiring fungi, aiding in the uptake of phosphate and other mineral nutrients. However, AM colonization is strongly reduced under high soil phosphate levels. A mechanistic understanding of phosphate sensing, phosphate starvation responses, and their connection to AM remains enigmatic. Here, we show that in Lotus japonicus , low-abundant, energy-rich inositol pyrophosphates act as master regulators of AM, orchestrating the crosstalk between phosphate starvation responses and plant root endosymbiosis. These findings hold promise for breeding nutrient-efficient crops.",
  "abstract_shown": true,
  "affiliations": [
    "Symbiosis Signalling Group, Department of Molecular Signal Processing, Leibniz Institute of Plant Biochemistry, 06120 Halle (Saale), Germany",
    "Leibniz Institute of Plant Biochemistry",
    "Institute of Crop Science and Resource Conservation (INRES), University of Bonn, 53115 Bonn, Germany",
    "University of Bonn",
    "Institute of Organic Chemistry and the Center for Integrative Biological Signalling Studies (CIBSS), Albert-Ludwigs-University of Freiburg, 79104 Freiburg, Germany",
    "University of Freiburg",
    "Department of Chemical Biology, Leibniz-Forschungsinstitut für Molekulare Pharmakologie, 13125 Berlin, Germany",
    "Institute of Chemistry, Humboldt-Universität zu Berlin, 12489 Berlin, Germany"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 16,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Kiran Raj",
      "orcid": "0009-0001-9189-8287"
    },
    {
      "affs": [
        2,
        3
      ],
      "name": "Verena Gaugler",
      "orcid": "0000-0002-3249-2922"
    },
    {
      "affs": [
        4,
        5
      ],
      "name": "Mengsi Lu"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Maren Schädel",
      "orcid": "0009-0001-7130-1981"
    },
    {
      "affs": [
        2,
        3
      ],
      "name": "Philipp Gaugler",
      "orcid": "0000-0002-9187-404X"
    },
    {
      "affs": [
        2,
        3
      ],
      "name": "Charlotte M. M. Grothaus",
      "orcid": "0009-0006-1334-1324"
    },
    {
      "affs": [
        2,
        3
      ],
      "name": "Ulrike A. Jochimsen"
    },
    {
      "affs": [
        0,
        5
      ],
      "name": "Athanasios Makris",
      "orcid": "0009-0004-1925-0699"
    },
    {
      "affs": [
        6,
        7,
        3
      ],
      "name": "Simon M. Bartsch",
      "orcid": "0000-0002-2215-7901"
    },
    {
      "affs": [
        2,
        5
      ],
      "name": "Anna M. Frentzen",
      "orcid": "0009-0009-1240-9325"
    },
    {
      "affs": [
        4,
        3
      ],
      "name": "Guizhen Liu",
      "orcid": "0000-0003-1748-6687"
    },
    {
      "affs": [
        2,
        1
      ],
      "name": "Michael Harings",
      "orcid": "0009-0007-1065-818X"
    },
    {
      "affs": [
        6,
        7
      ],
      "name": "Dorothea Fiedler",
      "orcid": "0000-0002-0798-946X"
    },
    {
      "affs": [
        4
      ],
      "name": "Henning Jacob Jessen",
      "orcid": "0000-0002-1025-9484"
    },
    {
      "affs": [
        2
      ],
      "name": "Gabriel Schaaf",
      "orcid": "0000-0001-9022-4515"
    },
    {
      "affs": [
        0
      ],
      "name": "Martina Katharina Ried",
      "orcid": "0000-0003-1582-5016"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/97sd06zv1ye9j.bib",
  "cited_by": 6,
  "doi": "10.1126/sciadv.aec5607",
  "fulltext_url": null,
  "id": "97sd06zv1ye9j",
  "issns": [
    "2375-2548"
  ],
  "landing_url": "https://doi.org/10.1126/sciadv.aec5607",
  "language": "en",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1110|Mycorrhizal Fungi and Plant Interactions"
    ]
  ],
  "openalex": "W4405673903",
  "pdf_url": "https://www.science.org/doi/pdf/10.1126/sciadv.aec5607?download=true",
  "pmcid": "PMC13196753",
  "pmid": "42172331",
  "published": "2026-05-22",
  "publisher": "American Association for the Advancement of Science",
  "ris": "https://research.draconitic.com/paper/97sd06zv1ye9j.ris",
  "sources": [
    {
      "first_seen": "2026-11-03T13:20:32Z",
      "native_id": "W4405673903",
      "source": "openalex",
      "url": "https://doi.org/10.1126/sciadv.aec5607"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:1110|Mycorrhizal Fungi and Plant Interactions",
      "subfield": "plant-biology"
    }
  ],
  "title": "Lotus japonicus VIH2 is an inositol pyrophosphate synthase that regulates arbuscular mycorrhiza",
  "title_text": "Lotus japonicus VIH2 is an inositol pyrophosphate synthase that regulates arbuscular mycorrhiza",
  "type": "peer-reviewed",
  "updated_at": "2026-11-08T13:20:45Z",
  "url": "https://research.draconitic.com/paper/97sd06zv1ye9j",
  "venue": "Science Advances",
  "versions": []
}