{
  "abstract": "BRI23, composed of the 23 last amino acids of the integral transmembrane protein 2B (ITM2B) C-terminus, is associated with several neurodegenerative diseases, including retinal dystrophy (RD) and familial dementia. Its role in the retina remains poorly understood. This study provides a comprehensive analysis of BRI23 interactome in the human retina. Using a peptide-bead coupling system, we identified 2302 proteins, primarily involved in mitochondrial processes, synaptic transmission and photoreceptor function. Our findings show that the BRI23-RD variant, associated with the ITM2B-related RD (IRRD), exhibits significantly altered protein interactions compared to the wild-type form. Notably, we observed an increased abundance of mitochondrial proteins and synaptic molecules, indicating a potential disruption of cellular pathways driven by the IRRD variant.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 17,
  "authors": [
    {
      "name": "Tasnim Ben Yacoub"
    },
    {
      "name": "Andréa Amprou"
    },
    {
      "name": "Camille Letellier"
    },
    {
      "name": "Christelle Michiels"
    },
    {
      "name": "Julien Navarro"
    },
    {
      "name": "Said El Shamieh"
    },
    {
      "name": "Tual Monfort"
    },
    {
      "name": "Salvatore Azzollini"
    },
    {
      "name": "Juliette Wohlschlegel"
    },
    {
      "name": "Guillaume Chevreux"
    },
    {
      "name": "Véronique Legros"
    },
    {
      "name": "Morgane Lemao"
    },
    {
      "name": "Guy Lenaers"
    },
    {
      "name": "Kate Grieve"
    },
    {
      "name": "Manuela Argentini"
    },
    {
      "name": "Christina Zeitz"
    },
    {
      "name": "Isabelle Audo"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/97ye6wxjmbgtg.bib",
  "cited_by": 0,
  "doi": "10.1038/s41598-026-53283-z",
  "fulltext_url": null,
  "id": "97ye6wxjmbgtg",
  "issns": [
    "2045-2322"
  ],
  "landing_url": "https://hal.science/hal-05797266v1",
  "language": "en",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "hal",
      "0.sdv"
    ],
    [
      "openalex",
      "1312|Retinal Development and Disorders"
    ]
  ],
  "openalex": "W7165668270",
  "pdf_url": "https://www.nature.com/articles/s41598-026-53283-z_reference.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-06-23",
  "publisher": "Nature Publishing Group",
  "ris": "https://research.draconitic.com/paper/97ye6wxjmbgtg.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:56Z",
      "native_id": "hal-05797266",
      "source": "hal",
      "url": "https://hal.science/hal-05797266v1"
    }
  ],
  "subjects": [
    {
      "field": "biochemistry",
      "origin": "openalex:1312|Retinal Development and Disorders",
      "subfield": "molecular-biology"
    }
  ],
  "title": "The ITM2B-associated retinal dystrophy mutation modifies BRI23 peptide interactions in the human retina",
  "title_text": "The ITM2B-associated retinal dystrophy mutation modifies BRI23 peptide interactions in the human retina",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:56Z",
  "url": "https://research.draconitic.com/paper/97ye6wxjmbgtg",
  "venue": "Scientific Reports",
  "versions": []
}