{
  "abstract": "Glioma remains largely refractory to immune-checkpoint blockade, in part because tumor-intrinsic mechanisms sustain programmed death-ligand 1 (PD-L1) and reinforce an immunosuppressive microenvironment. Tripartite motif-containing 14 (TRIM14) is an immune associated protein. However, the role of TRIM14 in PD-L1 homeostasis in glioma is incompletely defined. Here we reported that TRIM14 was increased in malignancies and was particularly associated with overall survival in glioma. Single-nucleus analysis showed that TRIM14-positive nuclei were predominantly malignant, indicating association between TRIM14 and glioma progression. We also found TRIM14 upregulated PD-L1 protein levels without materially changing CD274 mRNA in glioma cells. Additionally, knockout of TRIM14 reduced tumor growth in vivo . Mechanistically, TRIM14 recruits deubiquitinase BRCC3 to reduce K63-linked ubiquitination of PD-L1 in glioma cells, thereby inhibiting p62-mediated autophagic degradation of PD-L1. This pathway prompts that TRIM14 or BRCC3 maybe candidate targets for therapeutic intervention in glioma.",
  "abstract_shown": true,
  "affiliations": [
    "Institute of Precision Medicine, the First Affiliated Hospital, Sun Yat-sen University",
    "MOE Key Laboratory of Gene Function and Regulation, State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University",
    "Department of Critical Care Medicine, The First Affiliated Hospital of Sun Yat-sen University, Sun Yat-sen University",
    "Organ Transplant Center, The First Affiliated Hospital, Sun Yat-sen University"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Yan Wu"
    },
    {
      "affs": [
        1
      ],
      "name": "Xujun Wang"
    },
    {
      "affs": [
        1
      ],
      "name": "Mengqiu Li"
    },
    {
      "affs": [
        1
      ],
      "name": "Rong Wang"
    },
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Yaoxing Wu"
    },
    {
      "affs": [
        1,
        3
      ],
      "name": "Di Liu"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/980mabznqnz9a.bib",
  "cited_by": 0,
  "doi": "10.3389/fimmu.2026.1942769",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13710066/",
  "id": "980mabznqnz9a",
  "issns": [
    "1664-3224"
  ],
  "landing_url": "https://www.frontiersin.org/articles/10.3389/fimmu.2026.1942769/full",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Original Research"
    ],
    [
      "openalex",
      "2730|Cancer Immunotherapy and Biomarkers"
    ]
  ],
  "openalex": "W7221637493",
  "pdf_url": "https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2026.1942769/pdf",
  "pmcid": "PMC13710066",
  "pmid": "42947836",
  "published": "2026-10-13",
  "publisher": "Frontiers Media SA",
  "ris": "https://research.draconitic.com/paper/980mabznqnz9a.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:15Z",
      "native_id": "10.3389/fimmu.2026.1942769",
      "source": "crossref",
      "url": "https://www.frontiersin.org/articles/10.3389/fimmu.2026.1942769/full"
    },
    {
      "first_seen": "2026-10-31T12:21:06Z",
      "native_id": "PMC13710066",
      "source": "pmc",
      "url": "https://doi.org/10.3389/fimmu.2026.1942769"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2730|Cancer Immunotherapy and Biomarkers",
      "subfield": "oncology"
    }
  ],
  "title": "TRIM14 recruits BRCC3 to stabilize PD-L1 by suppressing p62-dependent selective autophagy in glioma",
  "title_text": "TRIM14 recruits BRCC3 to stabilize PD-L1 by suppressing p62-dependent selective autophagy in glioma",
  "type": "peer-reviewed",
  "updated_at": "2026-10-31T12:21:06Z",
  "url": "https://research.draconitic.com/paper/980mabznqnz9a",
  "venue": "Frontiers in Immunology",
  "versions": []
}