{
  "abstract": "Focused ultrasound (FUS) enables non-invasive, spatially precise modulation of biological tissues. This protocol describes assembly, calibration, and implementation of a diagnostic ultrasound-guided FUS (dUS-FUS) platform for real-time targeting of superficial and deep tissues in small-animal models. We demonstrate reversible sciatic nerve modulation in a rat acute pain model and assess sensory and motor functions using behavioral tests. The platform provides a reproducible workflow for image-guided tissue modulation and can be adapted to diverse preclinical applications. For complete details on the use and execution of this protocol, please refer to Sangwan et al.¹,².",
  "abstract_shown": true,
  "affiliations": [
    "Department of Anesthesiology, Perioperative and Pain Medicine, School of Medicine, Stanford University, Stanford, CA, USA.",
    "SONELE Inc., Markham, ON, Canada.",
    "Department of Anesthesiology, Perioperative and Pain Medicine, School of Medicine, Stanford University, Stanford, CA, USA. Electronic address: tanders0@stanford.edu."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 4,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Namrata Sangwan"
    },
    {
      "affs": [
        1
      ],
      "name": "N Chris Chaggares"
    },
    {
      "affs": [
        1
      ],
      "name": "Zahra Torbatian"
    },
    {
      "affs": [
        2
      ],
      "name": "Thomas Anthony Anderson"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/981ky3w8k9rj4.bib",
  "cited_by": 0,
  "doi": "10.1016/j.xpro.2026.104900",
  "fulltext_url": "https://europepmc.org/articles/PMC13695158",
  "id": "981ky3w8k9rj4",
  "issns": [
    "2666-1667"
  ],
  "landing_url": "https://europepmc.org/article/MED/42895854",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2204|Ultrasound and Hyperthermia Applications"
    ]
  ],
  "openalex": "W7222952983",
  "pdf_url": "https://europepmc.org/articles/PMC13695158?pdf=render",
  "pmcid": "PMC13695158",
  "pmid": "42895854",
  "published": "2026-10-19",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/981ky3w8k9rj4.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:32Z",
      "native_id": "MED:42895854",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42895854"
    }
  ],
  "subjects": [
    {
      "field": "biochemistry",
      "origin": "journal-openalex:1312|Single-cell and spatial transcriptomics",
      "subfield": "molecular-biology"
    }
  ],
  "title": "Image-guided focused ultrasound for non-invasive modulation of superficial and deep tissues.",
  "title_text": "Image-guided focused ultrasound for non-invasive modulation of superficial and deep tissues.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:19:32Z",
  "url": "https://research.draconitic.com/paper/981ky3w8k9rj4",
  "venue": "STAR protocols",
  "versions": []
}