{
  "abstract": "Efficient synaptic transmission requires coordinated exocytosis and endocytosis at the active zone and adjacent periactive zone, but whether scaffold proteins from these two presynaptic compartments function cooperatively remains unclear. Because the active-zone scaffold CLA-1 L genetically interacts with the periactive-zone scaffolds EHS-1 and ITSN-1 during presynaptic ATG-9 sorting, we tested whether these interactions extend to neurotransmission using aldicarb assays. Although cla-1 (ΔL) , ehs-1 (null) , and itsn-1 (null) mutants each exhibited mild aldicarb resistance, neither ehs-1 (null) nor itsn-1 (null) enhanced the neurotransmission defect of cla-1 (ΔL) mutants.",
  "abstract_shown": true,
  "affiliations": [
    "School of Biology and Ecology, University of Maine, Orono, ME, United States."
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 2,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Elaina Cote"
    },
    {
      "affs": [
        0
      ],
      "name": "Zhao Xuan"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/98mq4v4trsn31.bib",
  "cited_by": 0,
  "doi": "10.17912/micropub.biology.002331",
  "fulltext_url": "https://europepmc.org/articles/PMC13681198",
  "id": "98mq4v4trsn31",
  "issns": [
    "2578-9430"
  ],
  "landing_url": "https://europepmc.org/article/MED/42903352",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1307|Cellular transport and secretion"
    ]
  ],
  "openalex": "W7220387799",
  "pdf_url": "https://europepmc.org/articles/PMC13681198?pdf=render",
  "pmcid": "PMC13681198",
  "pmid": "42903352",
  "published": "2026-10-05",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/98mq4v4trsn31.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:57Z",
      "native_id": "MED:42903352",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42903352"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:1307|Cellular transport and secretion",
      "subfield": "cell-biology"
    }
  ],
  "title": "Loss of periactive-zone scaffold proteins does not enhance neurotransmission defects in cla-1(ΔL) mutants.",
  "title_text": "Loss of periactive-zone scaffold proteins does not enhance neurotransmission defects in cla-1(ΔL) mutants.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:19:57Z",
  "url": "https://research.draconitic.com/paper/98mq4v4trsn31",
  "venue": "MicroPublication biology",
  "versions": []
}