{
  "abstract": "Background and aims: People with diabetes and chronic kidney disease (CKD) may be at increased risk of iatrogenic hypoglycaemia. We compared rates of sensor-detected (SDH) and person-reported hypoglycaemia (PRH) in people with insulin-treated Type 2 diabetes (T2D) with and without CKD in the Hypo-METRICS study. Materials and method: Insulin-treated T2D patients with > 1 hypoglycaemic episode within the last 3 months wore a blinded continuous glucose monitor (CGM) and recorded PRH on the bespoke Hypo-METRICS app for 10 weeks. SDH was defined as per consensus guidelines. The participants were grouped based on estimated glomerular filtration rate (eGFR), that is CKD 1 (eGFR ≥ 90 mL/min; n = 117), CKD 2 (eGFR 60-89 mL/min; n = 140), and CKD 3 (eGFR 30-59 mL/min; n = 56). We used descriptive statistics, Kruskal-Wallis rank sum tests, and a negative binomial models to control for confounders. Results: In total, 313 participants with T2DM were included. Median age increased with declining eGFR (p < 0.001). Median (IQR) events per week for SDH < 3.9 mmol/L were 1.72 (0.66-3.43) in CKD 1, 2.12 (0.85-4.55) in CKD 2, and 2.22 (1.09-4.57) in CKD 3 (p = 0.12). For SDH < 3.0 mmol/L, these rates were 0.20 (0.00-0.50), 0.21 (0.10-0.61), and 0.20 (0.00-0.71), respectively (p = 0.88). PRH events had medians of 1.05 (0.40-2.12), 1.31 (0.61-2.42), and 1.28 (0.68-2.25) for CKD 1, CKD 2, and CKD 3 (p = 0.24). Conclusion: In people with insulin-treated T2DM and CKD stages 2 or 3, the rates of SDH and PRH do not significantly differ from those in people without CKD. Trial registration: ClinicalTRials.gov: NCT04304963.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 15,
  "authors": [
    {
      "name": "Julie Brøsen"
    },
    {
      "name": "Daniel Malmsiø"
    },
    {
      "name": "Patrick Divilly"
    },
    {
      "name": "Gilberte Martine-Edith"
    },
    {
      "name": "Natalie Zaremba"
    },
    {
      "name": "Namam Ali"
    },
    {
      "name": "Rory Mccrimmon"
    },
    {
      "name": "Simon Heller"
    },
    {
      "name": "Mark Evans"
    },
    {
      "name": "Bastiaan de Galan"
    },
    {
      "name": "Julia Mader"
    },
    {
      "name": "Eric Renard"
    },
    {
      "name": "Allan Vaag"
    },
    {
      "name": "Pratik Choudhary"
    },
    {
      "name": "Ulrik Pedersen-Bjergaard"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/99e4rr3r30k3v.bib",
  "cited_by": 0,
  "doi": "10.1111/dom.71247",
  "fulltext_url": null,
  "id": "99e4rr3r30k3v",
  "issns": [
    "1462-8902",
    "1463-1326"
  ],
  "landing_url": "https://hal.science/hal-05735919v1",
  "language": "en",
  "licence": "CC-BY-NC-ND-4.0",
  "licence_label": "CC BY-NC-ND 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "hal",
      "0.sdv"
    ],
    [
      "hal",
      "1.sdv.mhep"
    ],
    [
      "hal",
      "2.sdv.mhep.em"
    ],
    [
      "openalex",
      "2712|Diabetes Management and Research"
    ]
  ],
  "openalex": "W7204911750",
  "pdf_url": "https://hal.science/hal-05735919/document",
  "pmcid": null,
  "pmid": "42677701",
  "published": "2026-09-01",
  "publisher": "Wiley",
  "ris": "https://research.draconitic.com/paper/99e4rr3r30k3v.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:58Z",
      "native_id": "hal-05735919",
      "source": "hal",
      "url": "https://hal.science/hal-05735919v1"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "hal:0.sdv",
      "subfield": "general"
    },
    {
      "field": "medicine",
      "origin": "hal:2.sdv.mhep.em",
      "subfield": "endocrinology-metabolism"
    }
  ],
  "title": "Person‐Reported and Continuous Glucose Monitoring ( CGM ) Recorded Hypoglycaemia in People With Insulin‐Treated Type 2 Diabetes and Mild to Moderate Chronic Kidney Disease; Post Hoc Analysis From the Hypo‐ METRICS Study",
  "title_text": "Person‐Reported and Continuous Glucose Monitoring ( CGM ) Recorded Hypoglycaemia in People With Insulin‐Treated Type 2 Diabetes and Mild to Moderate Chronic Kidney Disease; Post Hoc Analysis From the Hypo‐ METRICS Study",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:58Z",
  "url": "https://research.draconitic.com/paper/99e4rr3r30k3v",
  "venue": "Diabetes, Obesity and Metabolism",
  "versions": []
}