{
  "abstract": "Background: Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is a heterogeneous clinical syndrome that includes NIH category IIIA (inflammatory) and IIIB (noninflammatory) presentations, with pelvic pain, urinary symptoms, sexual dysfunction, and variable immune findings.\n\nAim: To evaluate whether a p38 MAPK/MSK1/NF-κB network could amplify innate immune signaling in an immune-active subset of CP/CPPS.\n\nEvidence synthesis: Human evidence for coordinated p38, MSK1, and NF-κB activation in CP/CPPS is currently incomplete. p38 MAPK and NF-κB findings from prostatitis models and prostate-cell experiments provide disease-relevant support, whereas most MSK1, chromatin, mitochondrial-DAMP, and long-term inflammatory-memory links are extrapolated from non-prostatic inflammatory systems. MSK1 is activated by both p38 and ERK1/2 and has anti-inflammatory MSK1/2–DUSP1/IL-10 feedback functions; p65 Ser276 is one regulatory checkpoint among several NF-κB controls.\n\nConclusions: The proposed MSK1-dependent amplification loop is a testable hypothesis rather than a demonstrated CP/CPPS mechanism. Patient-tissue phosphoproteomics, cell-resolved transcriptomics and ATAC-seq, and phenotype-stratified intervention studies are needed before therapeutic claims can be made. No proposed p38, MSK1, Nrf2, NOX, or NLRP3 strategy currently has established clinical efficacy in CP/CPPS.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Andrology, The First Affiliated Hospital of Henan University of Chinese Medicine",
    "The First Clinical Medical College, Henan University of Chinese Medicine"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 2,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Yihang Shen"
    },
    {
      "affs": [
        0
      ],
      "name": "Baojun Ju"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/99t5pzpcw3a49.bib",
  "cited_by": 0,
  "doi": "10.3389/fimmu.2026.1955957",
  "fulltext_url": "https://www.frontiersin.org/articles/10.3389/fimmu.2026.1955957/full",
  "id": "99t5pzpcw3a49",
  "issns": [
    "1664-3224"
  ],
  "landing_url": "https://www.frontiersin.org/articles/10.3389/fimmu.2026.1955957/full",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "lcc",
      "RC581-607"
    ]
  ],
  "openalex": null,
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-29",
  "publisher": "Frontiers Media SA",
  "ris": "https://research.draconitic.com/paper/99t5pzpcw3a49.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:19Z",
      "native_id": "10.3389/fimmu.2026.1955957",
      "source": "crossref",
      "url": "https://www.frontiersin.org/articles/10.3389/fimmu.2026.1955957/full"
    },
    {
      "first_seen": "2026-10-31T14:22:33Z",
      "native_id": "0bda0c1d82544aa0b14065fb80802b80",
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      "url": "https://doi.org/10.3389/fimmu.2026.1955957"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "issn:1664-3224",
      "subfield": "immunology"
    },
    {
      "field": "medicine",
      "origin": "lcc:RC581-607",
      "subfield": "general"
    }
  ],
  "title": "The p38 MAPK/MSK1/NF-κB axis in chronic prostatitis/chronic pelvic pain syndrome: a testable hypothesis for innate immune inflammatory amplification",
  "title_text": "The p38 MAPK/MSK1/NF-κB axis in chronic prostatitis/chronic pelvic pain syndrome: a testable hypothesis for innate immune inflammatory amplification",
  "type": "peer-reviewed",
  "updated_at": "2026-10-31T14:22:33Z",
  "url": "https://research.draconitic.com/paper/99t5pzpcw3a49",
  "venue": "Frontiers in Immunology",
  "versions": []
}