{
  "abstract": "Background: Doxorubicin-induced cardiotoxicity can manifest years after exposure and may mimic other cardiomyopathies in young patients, making the diagnosis of delayed doxorubicin cardiotoxicity challenging in these patients.\n\nCase Summary: A 26-year-old physically active man with childhood Burkitt’s lymphoma treated with doxorubicin (120 mg/m2 cumulative) presented with exertional chest discomfort and palpitations. Resting electrocardiogram and ambulatory monitoring were unremarkable. Transthoracic echocardiography demonstrated preserved ejection fraction (55%-60%) but reduced global longitudinal strain (−15%). Cardiac magnetic resonance revealed low-normal biventricular function with nonischemic septal late gadolinium enhancement and reduced strain. Exercise stress testing demonstrated impaired contractile reserve, septal mechanical dyssynchrony, and exercise-induced QRS prolongation. Coronary computed tomography angiography excluded coronary artery disease.\n\nDiscussion: This case highlights that anthracycline cardiotoxicity may present late, mimic myocardial ischemia, arrhythmogenic cardiomyopathy, and other cardiomyopathies.\n\nTake-Home Message: A high index of suspicion is required for late cardiotoxicity in young cancer survivors.",
  "abstract_shown": true,
  "affiliations": [
    "Allina Health Minneapolis Heart Institute, Abbott Northwestern Hospital, Minneapolis, Minnesota, USA",
    "Minneapolis Heart Institute Foundation, Minneapolis, Minnesota, USA"
  ],
  "article_type": "case report",
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Maroun Chedid"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Collin Barrett"
    },
    {
      "affs": [
        1
      ],
      "name": "Melanie Sun"
    },
    {
      "affs": [
        0
      ],
      "name": "Andrew Lesser"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Katarxyna Hryniewicz"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/99wcmgm1cjqqm.bib",
  "cited_by": 1,
  "doi": "10.1016/j.jaccas.2026.110273",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13699096/",
  "id": "99wcmgm1cjqqm",
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    "2666-0849"
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  "landing_url": "https://doi.org/10.1016/j.jaccas.2026.110273",
  "language": "en",
  "licence": "CC-BY-NC-ND-4.0",
  "licence_label": "CC BY-NC-ND 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Cardio-Oncology"
    ],
    [
      "heading",
      "Clinical Case"
    ],
    [
      "lcc",
      "RC666-701"
    ],
    [
      "openalex",
      "2705|Chemotherapy-induced cardiotoxicity and mitigation"
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  "openalex": "W7212112477",
  "pdf_url": "https://www.jacc.org/doi/pdf/10.1016/j.jaccas.2026.110273?download=true",
  "pmcid": "PMC13699096",
  "pmid": "42726042",
  "published": "2026-09-11",
  "publisher": "Elsevier",
  "ris": "https://research.draconitic.com/paper/99wcmgm1cjqqm.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:46Z",
      "native_id": "PMC13699096",
      "source": "pmc",
      "url": "https://doi.org/10.1016/j.jaccas.2026.110273"
    },
    {
      "first_seen": "2026-10-30T13:43:16Z",
      "native_id": "d1ed91ca818340e981e826b867da86e6",
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      "url": "https://doi.org/10.1016/j.jaccas.2026.110273"
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  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2705|Chemotherapy-induced cardiotoxicity and mitigation",
      "subfield": "cardiovascular"
    }
  ],
  "title": "Late Anthracycline Cardiotoxicity Mimicking Arrhythmogenic Cardiomyopathy in a Young Adult",
  "title_text": "Late Anthracycline Cardiotoxicity Mimicking Arrhythmogenic Cardiomyopathy in a Young Adult",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T13:43:16Z",
  "url": "https://research.draconitic.com/paper/99wcmgm1cjqqm",
  "venue": "JACC Case Reports",
  "versions": []
}