{
  "abstract": "Clonal hematopoiesis of indeterminate potential (CHIP) is the presence of hematologic malignancy-associated somatic mutations in patients without hematologic malignancies. In multiple myeloma (MM), the implications of CHIP on chimeric antigen receptor (CAR)-T cell outcomes and toxicities have yet to be fully explored. In a retrospective study at UCLA, we explored the association between CHIP and clinical outcomes of 68 adult patients with MM (31% with CHIP mutations) who were undergoing CAR-T cell therapy from 6/1/2021 to 12/31/2024. The overall (95% CHIP vs. 93% no CHIP; p = 0.99) and complete response rates (81% CHIP vs. 67% no CHIP; p = 0.15) did not differ by CHIP status. Similarly, CHIP mutations did not impact progression-free survival (HR 0.83; 95% CI 0.38–1.83; p = 0.65) or overall survival (HR 0.76; 95% CI 0.24–2.45; p = 0.65). Patients with CHIP mutations were more likely to develop CRS (100% vs. 70%; p = 0.007); however, there was no difference in the incidence of ICANS (33% CHIP vs. 17% no CHIP, p = 0.20). Our results show that although CHIP did not negatively influence response rate, complete response rate, survival, or progression-free survival in MM patients after CAR-T cell therapy, it did confer a higher risk of inflammatory response with increased frequency and grade of CRS.\n\nSupplementary Information: The online version contains supplementary material available at https://doi.org/10.1007/s12185-026-04249-4.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Medicine, Division of Hematology/Oncology, UCLA, Los Angeles, CA USA",
    "Department of Medical Oncology, Massachusetts General Hospital, Boston, MA USA",
    "Department of Medicine Statistics Core, UCLA, Los Angeles, CA USA",
    "Department of Pathology and Laboratory Medicine, UCLA, Los Angeles, CA USA",
    "Department of Pathology & Laboratory Medicine, School of Medicine, University of California, Irvine, CA USA"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 8,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Sophie G. Carlson",
      "orcid": "0009-0007-6686-1494"
    },
    {
      "affs": [
        1
      ],
      "name": "Benjamin R. Puliafito"
    },
    {
      "affs": [
        2
      ],
      "name": "Kosuke Kawai"
    },
    {
      "affs": [
        3
      ],
      "name": "T. Niroshi Senaratne"
    },
    {
      "affs": [
        3,
        4
      ],
      "name": "Thomas D. Lee"
    },
    {
      "affs": [
        0
      ],
      "name": "Tasha Lin"
    },
    {
      "affs": [
        0
      ],
      "name": "John Timmerman"
    },
    {
      "affs": [
        0
      ],
      "name": "Sarah M. Larson"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/9a1gb07a22nqc.bib",
  "cited_by": 0,
  "doi": "10.1007/s12185-026-04249-4",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13719782/",
  "id": "9a1gb07a22nqc",
  "issns": [
    "0925-5710",
    "1865-3774"
  ],
  "landing_url": "https://doi.org/10.1007/s12185-026-04249-4",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Original Article"
    ],
    [
      "openalex",
      "2730|CAR-T cell therapy research"
    ]
  ],
  "openalex": "W7169649982",
  "pdf_url": "https://link.springer.com/content/pdf/10.1007/s12185-026-04249-4.pdf",
  "pmcid": "PMC13719782",
  "pmid": "42470580",
  "published": "2026-07-18",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/9a1gb07a22nqc.ris",
  "sources": [
    {
      "first_seen": "2026-11-02T12:23:41Z",
      "native_id": "PMC13719782",
      "source": "pmc",
      "url": "https://doi.org/10.1007/s12185-026-04249-4"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2730|CAR-T cell therapy research",
      "subfield": "oncology"
    }
  ],
  "title": "Impact of clonal hematopoiesis of indeterminate potential on treatment outcomes in multiple myeloma patients undergoing CAR-T cell therapy",
  "title_text": "Impact of clonal hematopoiesis of indeterminate potential on treatment outcomes in multiple myeloma patients undergoing CAR-T cell therapy",
  "type": "peer-reviewed",
  "updated_at": "2026-11-03T12:20:47Z",
  "url": "https://research.draconitic.com/paper/9a1gb07a22nqc",
  "venue": "International Journal of Hematology",
  "versions": []
}