{
  "abstract": "Objective\n\nGiven the established association of interleukin-18 (IL-18) and IL-18 receptor accessory protein (IL-18RAP) with autoimmune liver diseases (AILD), while their specific mechanism remains unclear, this study aimed to investigate the expression and functional significance of IL-18RAP in neutrophils from patients with AILD.Methods\n\nThe expression levels of IL-18RAP were determined by quantitative reverse transcription polymerase chain reaction (qRT-PCR) and Western blot. Serum type I interferon (IFN) concentrations were measured by enzyme-linked immunosorbent assay (ELISA). In vitro cell experiments were conducted to assess chemotactic phagocytosis and to analyze the regulatory effect of IL-18RAP on neutrophil function. In vitro IFN stimulation experiments were performed to analyze the relationship between IL-18RAP expression and type I IFN.Results\n\nIL-18RAP mRNA and protein expression levels were increased in patients with AILD. After IL-18 stimulation, the chemotaxis index and nitroblue tetrazolium (NBT) reduction rate of neutrophils in the AILD group increased (P < 0.05). Serum type I IFN concentrations were elevated in AILD patients (Z = -2.14, P = 0.032). IL-18RAP mRNA expression was upregulated in the group stimulated with high-concentration patient serum and in the human recombinant IFN-α stimulation group, indicating that high concentrations of type I IFN can upregulate IL-18RAP expression in neutrophils.Conclusion\n\nElevated IL-18RAP expression in AILD patients enhanced the chemotactic, phagocytic, and bactericidal functions of neutrophils. Higher serum type I IFN levels in AILD patients upregulated IL-18RAP expression in neutrophils, suggesting that type I IFN contributes to the pathogenesis of AILD by upregulating IL-18RAP.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Clinical Laboratory, Hunan Provincial People's Hospital, Department of Pathology, QiluHospital of Shandong University Dezhou Hospital, Dezhou, China.",
    "Hunan Provincial People's Hospital, The First Affiliated Hospital of Hunan Normal University, No. 61, Jiefang West Road, Changsha, Hunan Province, China, Changsha, 410000, China.",
    "Department of Clinical Laboratory, The Affiliated Huizhou Hospital, Guangzhou Medical University, Huizhou, China.",
    "Changsha County People's Hospital (Xingsha Hospital District of Hunan Provincial People's Hospital), Changsha, China."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 7,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Wenwen Jin"
    },
    {
      "affs": [
        2
      ],
      "name": "Xi Su"
    },
    {
      "affs": [
        2
      ],
      "name": "Lizhi Liu"
    },
    {
      "affs": [
        2
      ],
      "name": "Shilin Du"
    },
    {
      "affs": [
        2
      ],
      "name": "Wenting Xiong"
    },
    {
      "affs": [
        3
      ],
      "name": "Zifei Zhu"
    },
    {
      "affs": [
        2
      ],
      "name": "Cunyan Li"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/9a366pjrn918h.bib",
  "cited_by": 0,
  "doi": "10.1016/j.jtauto.2026.100406",
  "fulltext_url": "https://europepmc.org/articles/PMC13677575",
  "id": "9a366pjrn918h",
  "issns": [
    "2589-9090"
  ],
  "landing_url": "https://europepmc.org/article/MED/42898347",
  "language": "eng",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2721|Liver Diseases and Immunity"
    ]
  ],
  "openalex": "W7215079420",
  "pdf_url": "https://europepmc.org/articles/PMC13677575?pdf=render",
  "pmcid": "PMC13677575",
  "pmid": "42898347",
  "published": "2026-10-01",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/9a366pjrn918h.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:37Z",
      "native_id": "MED:42898347",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42898347"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2721|Liver Diseases and Immunity",
      "subfield": "general"
    }
  ],
  "title": "Type I interferon upregulates IL-18RAP in neutrophils to enhance chemotaxis and bactericidal activity in autoimmune liver diseases.",
  "title_text": "Type I interferon upregulates IL-18RAP in neutrophils to enhance chemotaxis and bactericidal activity in autoimmune liver diseases.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:19:37Z",
  "url": "https://research.draconitic.com/paper/9a366pjrn918h",
  "venue": "Journal of translational autoimmunity",
  "versions": []
}