{
  "abstract": "INTRODUCTION: Harmonized cognitive composites are widely used to study longitudinal cognitive decline. Although harmonization places scores on a common latent scale, measurement precision varies across visits, age, and diagnosis, but is typically ignored in longitudinal models.\n\nMETHODS: We analyzed harmonized memory scores and time‐varying standard errors from the National Alzheimer's Coordinating Center Uniform Data Set. We compared a naïve mixed‐effects model that did not incorporate measurement uncertainty with two precision‐aware models: a frequentist precision‐weighted and a Bayesian measurement‐error model. Comparisons were based on estimated age of memory impairment.\n\nRESULTS: Accounting for measurement precision produced age‐dependent differences in estimated memory trajectories. Naïve models predicted higher memory scores at older ages in cognitively normal and mildly impaired participants but lower scores in Alzheimer's dementia (AD). Precision‐aware models estimated threshold crossing 1.5–3 years earlier than the naïve model.\n\nDISCUSSION: Incorporating visit‐specific measurement precision alters estimated cognitive trajectories and the timing of clinically interpretable memory impairment.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Psychiatry and Behavioral Sciences University of Washington Seattle Washington USA",
    "VA Puget Sound Health Care System, GRECC Seattle Washington USA",
    "Bordeaux Population Health Research Center University of Bordeaux, Inserm Bordeaux France",
    "Department of Medicine University of Washington Seattle Washington USA",
    "Department of Neurology Boston University Chobanian & Avedisian School of Medicine Boston Massachusetts USA",
    "Indiana Alzheimer's Disease Research Center and Center for Neuroimaging Indiana University School of Medicine Indianapolis Indiana USA",
    "Department of Medical and Molecular Genetics, Department of Radiology and Imaging Sciences Indiana University School of Medicine Indianapolis Indiana USA"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 8,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Emily H. Trittschuh"
    },
    {
      "affs": [
        2
      ],
      "name": "Phoebe Scollard"
    },
    {
      "affs": [
        3
      ],
      "name": "Paul K. Crane"
    },
    {
      "affs": [
        3
      ],
      "name": "Seo‐Eun Choi"
    },
    {
      "affs": [
        4
      ],
      "name": "Jesse Mez"
    },
    {
      "affs": [
        5,
        6
      ],
      "name": "Andrew J. Saykin"
    },
    {
      "affs": [
        3
      ],
      "name": "Laura E. Gibbons"
    },
    {
      "affs": [
        3
      ],
      "name": "Shubhabrata Mukherjee",
      "orcid": "0000-0003-2522-2884"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/9ab4bgasqfcq7.bib",
  "cited_by": 0,
  "doi": "10.1002/alz.71976",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13736550/",
  "id": "9ab4bgasqfcq7",
  "issns": [
    "1552-5260",
    "1552-5279"
  ],
  "landing_url": "https://doi.org/10.1002/alz.71976",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Research Article"
    ],
    [
      "openalex",
      "2738|Dementia and Cognitive Impairment Research"
    ]
  ],
  "openalex": "W7225257939",
  "pdf_url": "https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/alz.71976",
  "pmcid": "PMC13736550",
  "pmid": "42982742",
  "published": "2026-11-04",
  "publisher": "Wiley",
  "ris": "https://research.draconitic.com/paper/9ab4bgasqfcq7.ris",
  "sources": [
    {
      "first_seen": "2026-11-09T12:21:58Z",
      "native_id": "PMC13736550",
      "source": "pmc",
      "url": "https://doi.org/10.1002/alz.71976"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2738|Dementia and Cognitive Impairment Research",
      "subfield": "psychiatry"
    }
  ],
  "title": "Measurement precision matters: Accounting for uncertainty alters estimated memory trajectories across the cognitive spectrum",
  "title_text": "Measurement precision matters: Accounting for uncertainty alters estimated memory trajectories across the cognitive spectrum",
  "type": "peer-reviewed",
  "updated_at": "2026-11-09T12:21:58Z",
  "url": "https://research.draconitic.com/paper/9ab4bgasqfcq7",
  "venue": "Alzheimer's & Dementia",
  "versions": []
}