{
  "abstract": "Oxygen levels in the ocean have decreased worldwide as a result of climate change and nutrient contamination, which has had a significant impact on marine ecosystems. Although deep-sea fish that reside in oxygen minimum zones (OMZs) demonstrate remarkable adaptations to hypoxia, the molecular mechanisms that underlie their resilience are still inadequately understood. The hypoxia-inducible factors (HIFs), regulated by the hypoxia signaling pathway, play a crucial role in maintaining cellular and systemic oxygen homeostasis in response to changes in oxygen supply. In this study, we investigated the HIFs pathway in three deep-sea fish species: Pseudoliparis swirei, Ilyophis sp., and Liparis tanakai. We found that Ilyophis sp. HIF-1α shows stronger transcriptional activity and upregulates hypoxia-response genes more efficiently than the other species. Mutational analysis revealed that the deletion mutation of the nuclear export signal (NES) in Ilyophis sp. HIF-1α may enhance its stability, while Plk3 may function as a negative regulator of deep-sea fish HIF-1α under hypoxic conditions. This study reveals divergent evolutionary strategies in hypoxia adaptation among deep-sea fishes, highlighting how structural and regulatory mechanisms enable survival in oxygen-deprived environments, and provides novel insights into the genetic mechanisms enabling survival in OMZs, advancing our understanding of marine hypoxia resilience and its implications for ecosystem dynamics under global deoxygenation.",
  "abstract_shown": true,
  "affiliations": [
    "Institute of Deep-sea Science and Engineering, Chinese Academy of Sciences, Sanya, Hainan 572000, China",
    "State Key Laboratory of Breeding Biotechnology and Sustainable Aquaculture, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, Hubei 430072, China",
    "University of Chinese Academy of Sciences, Beijing 100049, China"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 11,
  "authors": [
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Geng Ai"
    },
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Wen-Yu Fang"
    },
    {
      "affs": [
        1,
        2
      ],
      "name": "Ya-Nan Song"
    },
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Han Xu"
    },
    {
      "affs": [
        1,
        2
      ],
      "name": "Tong Li"
    },
    {
      "affs": [
        1,
        2
      ],
      "name": "Rui-Tong Hu"
    },
    {
      "affs": [
        1,
        2
      ],
      "name": "Jing Wang"
    },
    {
      "affs": [
        1,
        2
      ],
      "name": "Wu-Han Xiao"
    },
    {
      "affs": [
        0
      ],
      "name": "Li-Sheng He"
    },
    {
      "affs": [
        1
      ],
      "name": "Xiao-Ni Gan"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Shun-Ping He"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/9asvqkzykk4zt.bib",
  "cited_by": 0,
  "doi": "10.24272/j.issn.2095-8137.2025.510",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13720435/",
  "id": "9asvqkzykk4zt",
  "issns": [
    "2095-8137"
  ],
  "landing_url": "https://doi.org/10.24272/j.issn.2095-8137.2025.510",
  "language": "en",
  "licence": "CC-BY-NC-4.0",
  "licence_label": "CC BY-NC 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Article"
    ],
    [
      "openalex",
      "2303|Physiological and biochemical adaptations"
    ]
  ],
  "openalex": "W7133240694",
  "pdf_url": "https://www.zoores.ac.cn/en/article/pdf/preview/10.24272/j.issn.2095-8137.2025.510.pdf",
  "pmcid": "PMC13720435",
  "pmid": "42706785",
  "published": "2026-09-18",
  "publisher": "Editorial Office of Zoological Research, Kunming Institute of Zoology, The Chinese Academy of Sciences",
  "ris": "https://research.draconitic.com/paper/9asvqkzykk4zt.ris",
  "sources": [
    {
      "first_seen": "2026-11-03T12:21:19Z",
      "native_id": "PMC13720435",
      "source": "pmc",
      "url": "https://doi.org/10.24272/j.issn.2095-8137.2025.510"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:2303|Physiological and biochemical adaptations",
      "subfield": "ecology"
    }
  ],
  "title": "Analysis of hypoxia-inducible factors in the deep-sea fish reveals genetic adaptation to hypoxic environments",
  "title_text": "Analysis of hypoxia-inducible factors in the deep-sea fish reveals genetic adaptation to hypoxic environments",
  "type": "peer-reviewed",
  "updated_at": "2026-11-03T12:21:19Z",
  "url": "https://research.draconitic.com/paper/9asvqkzykk4zt",
  "venue": "Zoological Research",
  "versions": []
}