{
  "abstract": "Ribosomes, the molecular machines responsible for protein synthesis, are fundamental to all cellular life. Although the higher-level architecture of ribosomes is conserved, a small subunit acting as the mRNA decoding site and a large subunit that catalyses peptide bond formation, there are differences in the numbers of components of each of the subunits between the 3 domains of life. Despite their well-established role in translating genetic information into functional proteins, many complexities in ribosome biology and functionality are only just being revealed. Defects in ribosomal components contribute to a class of disorders termed ribosomopathies that come with a range of symptoms and severities. Here we show that a mutation in the Drosophila ribosomal protein RpL39 causes an anterior-posterior embryonic patterning defect through impaired accumulation of the hox protein Abdominal-A (abdA). Deletions uncovering subunits of the Nascent peptide-Associated Complex (NAC) and Ribosome-Associated Complex (RAC) act as genetic enhancers of the RpL39 mutation leading us to speculate that RpL39 forms a relay between the nascent peptide in the exit tunnel and the exterior surface of the ribosome, modulating the interaction with these ribosomally-associated complexes. This work enhances our knowledge of the roles played by individual ribosome components and feeds into our understanding of the mechanisms of ribosome quality control.",
  "abstract_shown": true,
  "affiliations": [
    "University of Nottingham"
  ],
  "article_type": "New results",
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "name": "M. R. McFarland"
    },
    {
      "name": "R. Tripathy"
    },
    {
      "name": "J. K. Bergman"
    },
    {
      "name": "M. L. Wood"
    },
    {
      "affs": [
        0
      ],
      "name": "A. D. Renault"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/9aw02tjyf6z3k.bib",
  "cited_by": 0,
  "doi": "10.64898/2026.10.23.761343",
  "fulltext_url": "https://www.biorxiv.org/content/10.64898/2026.10.23.761343v1.full",
  "id": "9aw02tjyf6z3k",
  "issns": [],
  "landing_url": "https://www.biorxiv.org/content/10.64898/2026.10.23.761343v1",
  "language": null,
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "biorxiv",
      "cell biology"
    ],
    [
      "openalex",
      "1312|RNA and protein synthesis mechanisms"
    ]
  ],
  "openalex": "W7223691228",
  "pdf_url": "https://www.biorxiv.org/content/10.64898/2026.10.23.761343v1.full.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-23",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/9aw02tjyf6z3k.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:29:41Z",
      "native_id": "10.64898/2026.10.23.761343",
      "source": "biorxiv",
      "url": "https://www.biorxiv.org/content/10.64898/2026.10.23.761343v1"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "biorxiv:cell biology",
      "subfield": "cell-biology"
    }
  ],
  "title": "A ribosome exit tunnel component is required for robust expression of the Drosophila hox gene, abdominal A",
  "title_text": "A ribosome exit tunnel component is required for robust expression of the Drosophila hox gene, abdominal A",
  "type": "preprint",
  "updated_at": "2026-10-30T12:29:41Z",
  "url": "https://research.draconitic.com/paper/9aw02tjyf6z3k",
  "venue": "bioRxiv",
  "versions": []
}