{
  "abstract": "Affinity sensing of nucleic acids is among the most investigated areas in biosensing due to the growing importance of DNA diagnostics in healthcare research and clinical applications. Here, we report a simple electrochemical DNA detection layer, based on poly-l-lysine (PLL), in combination with gold nanoparticles (AuNPs) as a signal amplifier. The layer shows excellent reduction of non-specific binding and thereby high contrast between amplified and non-amplified signals with functionalized AuNPs; the relative change in current was 10-fold compared to the non-amplified signal. The present work may provide a general method for the detection of tumor markers based on electrochemical DNA sensing.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 2,
  "authors": [
    {
      "name": "Almudena Marti"
    },
    {
      "name": "Jurriaan Huskens"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/9c7z3k724r3ph.bib",
  "cited_by": 11,
  "doi": "10.3390/nano12020242",
  "fulltext_url": null,
  "id": "9c7z3k724r3ph",
  "issns": [
    "2079-4991",
    "2079-4991"
  ],
  "landing_url": "https://hal.univ-lorraine.fr/hal-03562538v1",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "hal",
      "0.chim"
    ],
    [
      "hal",
      "1.chim.anal"
    ],
    [
      "hal",
      "1.chim.mate"
    ],
    [
      "openalex",
      "1312|Advanced biosensing and bioanalysis techniques"
    ]
  ],
  "openalex": "W4206661327",
  "pdf_url": "https://hal.univ-lorraine.fr/hal-03562538/document",
  "pmcid": null,
  "pmid": null,
  "published": "2026-09-09",
  "publisher": "MDPI",
  "ris": "https://research.draconitic.com/paper/9c7z3k724r3ph.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:31Z",
      "native_id": "hal-03562538",
      "source": "hal",
      "url": "https://hal.univ-lorraine.fr/hal-03562538v1"
    }
  ],
  "subjects": [
    {
      "field": "chemistry",
      "origin": "hal:1.chim.anal",
      "subfield": "analytical"
    },
    {
      "field": "chemistry",
      "origin": "hal:1.chim.mate",
      "subfield": "materials-polymers"
    }
  ],
  "title": "Au Nanoparticle-Based Amplified DNA Detection on Poly-l-lysine Monolayer-Functionalized Electrodes",
  "title_text": "Au Nanoparticle-Based Amplified DNA Detection on Poly-l-lysine Monolayer-Functionalized Electrodes",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:31Z",
  "url": "https://research.draconitic.com/paper/9c7z3k724r3ph",
  "venue": "Nanomaterials",
  "versions": []
}