{
  "abstract": "Local therapeutic platforms capable of concurrent tumor-cell elimination and antiangiogenic activity are urgently needed. This study presents a Rhein/Pectin@Zn hydrogel fabricated through supramolecular self-assembly and metal-coordination crosslinking and administered by dual-syringe in situ gelation. Hydrogels prepared under standardized ex vivo crosslinking conditions display a porous microstructure, stable gel characteristics, shear-dependent flow behavior, and accelerated cargo release under acidic conditions. Biological evaluations indicate antiproliferative and pro-apoptotic effects against tumor cells, together with reduced endothelial angiogenic signaling. Repeated intratumoral delivery in a subcutaneous B16 melanoma model reduced endpoint tumor volume and weight without overt major-organ histopathological abnormalities in the displayed fields. Integrated transcriptomic and molecular analyses implicated cell-cycle checkpoint disruption and apoptosis-associated signaling in the observed antitumor response. Collectively, this work positions Rhein/Pectin@Zn as an in situ-forming hydrogel for local cancer therapy.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Biomedical Engineering, Southern University of Science and Technology, Shenzhen, Guangdong, PR China.",
    "Department of Immunology, Fourth Military Medical University, Xi'an, Shaanxi, PR China.",
    "Department of Joint and Orthopedics, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, PR China.",
    "Department of Stomatology, Shenzhen University General Hospital, Shenzhen University, Shenzhen, Guangdong, PR China.",
    "Guangdong Provincial Key Laboratory of Advanced Biomaterials, PR China."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 8,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Kai Li"
    },
    {
      "affs": [
        0
      ],
      "name": "Qili Sun"
    },
    {
      "affs": [
        2
      ],
      "name": "Jingle Chen"
    },
    {
      "affs": [
        0
      ],
      "name": "YanSong Wang"
    },
    {
      "affs": [
        0
      ],
      "name": "Enze Zhao"
    },
    {
      "affs": [
        3
      ],
      "name": "Shuaishuai Cao"
    },
    {
      "affs": [
        2
      ],
      "name": "Chao Xie"
    },
    {
      "affs": [
        0,
        4
      ],
      "name": "Bin Tang"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/9cankssfy8csz.bib",
  "cited_by": 0,
  "doi": "10.1016/j.mtbio.2026.103733",
  "fulltext_url": "https://europepmc.org/articles/PMC13685458",
  "id": "9cankssfy8csz",
  "issns": [
    "2590-0064"
  ],
  "landing_url": "https://europepmc.org/article/MED/42910188",
  "language": "eng",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1313|Hydrogels: synthesis, properties, applications"
    ]
  ],
  "openalex": "W7220834412",
  "pdf_url": "https://europepmc.org/articles/PMC13685458?pdf=render",
  "pmcid": "PMC13685458",
  "pmid": "42910188",
  "published": "2026-10-07",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/9cankssfy8csz.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:20:10Z",
      "native_id": "MED:42910188",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42910188"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:1313|Hydrogels: synthesis, properties, applications",
      "subfield": "general"
    }
  ],
  "title": "Coordination-strengthened Rhein/Pectin@Zn dual-network hydrogel for local antitumor therapy.",
  "title_text": "Coordination-strengthened Rhein/Pectin@Zn dual-network hydrogel for local antitumor therapy.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:20:10Z",
  "url": "https://research.draconitic.com/paper/9cankssfy8csz",
  "venue": "Materials today. Bio",
  "versions": []
}