{
  "abstract": "TH17 cells play a central role in several human autoimmune diseases. We and others reported the nuclear receptor, REV-ERBα, as a cell-intrinsic repressor of TH17-mediated pathogenicity. REV-ERBβ, REV-ERBα's closely related family member, is thought to be functionally redundant to REV-ERBα, which we sought to explore in TH17-mediated immunity. Our data indicate that deletion of REV-ERBβ enhances TH17-mediated pro-inflammatory cytokine expression and exacerbated disease in mouse models of multiple sclerosis and colitis. RNA-sequencing indicates REV-ERBβ and REV-ERBα do not have similar transcriptional profiles in TH17 cells. REV-ERBβ does not appear to strongly rely on interaction with the classic co-repressor NCoR1 to regulate gene expression, which is in contrast to REV-ERBα in TH17 cells, nor does it utilize heme, its known endogenous ligand for its repressive functions. Our results establish that while REV-ERBβ also acts as a negative regulator of TH17-cell function and pathogenicity, it does so in a manner that is non-redundant, independent, and unique to REV-ERBα.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": "Article",
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "name": "Sean Campbell"
    },
    {
      "name": "Sarah A. Mosure"
    },
    {
      "name": "Mohammed Amir"
    },
    {
      "name": "Jonathan Chuck"
    },
    {
      "name": "Qun Lu"
    },
    {
      "name": "Laura A. Solt",
      "orcid": "0000-0001-8807-0342"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/9cbra45nsgma6.bib",
  "cited_by": 0,
  "doi": "10.1016/j.isci.2026.117577",
  "fulltext_url": "https://europepmc.org/articles/PMC13691276",
  "id": "9cbra45nsgma6",
  "issns": [
    "2589-0042"
  ],
  "landing_url": "https://www.cell.com/iscience/fulltext/S2589-0042(26)02956-1",
  "language": "eng",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "http://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Cell biology"
    ],
    [
      "heading",
      "Immunology"
    ],
    [
      "openalex",
      "2403|Psoriasis: Treatment and Pathogenesis"
    ]
  ],
  "openalex": "W7221932809",
  "pdf_url": "https://europepmc.org/articles/PMC13691276?pdf=render",
  "pmcid": "PMC13691276",
  "pmid": "42920935",
  "published": "2026-10-15",
  "publisher": "Elsevier BV",
  "ris": "https://research.draconitic.com/paper/9cbra45nsgma6.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:16Z",
      "native_id": "10.1016/j.isci.2026.117577",
      "source": "feed-cell",
      "url": "https://www.cell.com/iscience/fulltext/S2589-0042(26)02956-1"
    },
    {
      "first_seen": "2026-10-30T12:17:49Z",
      "native_id": "10.1016/j.isci.2026.117577",
      "source": "crossref",
      "url": "https://linkinghub.elsevier.com/retrieve/pii/S2589004226029561"
    },
    {
      "first_seen": "2026-10-30T12:20:33Z",
      "native_id": "MED:42920935",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42920935"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "heading:Cell biology",
      "subfield": "cell-biology"
    },
    {
      "field": "biology",
      "origin": "heading:Immunology",
      "subfield": "immunology"
    }
  ],
  "title": "Negative regulation of TH17-mediated inflammation by the nuclear receptor REV-ERBβ",
  "title_text": "Negative regulation of TH17-mediated inflammation by the nuclear receptor REV-ERBβ",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:20:33Z",
  "url": "https://research.draconitic.com/paper/9cbra45nsgma6",
  "venue": "iScience",
  "versions": []
}