{
  "abstract": "Purpose: To evaluate endophthalmitis rates following intravitreal injection of aflibercept, comparing between vial preparation and prefilled syringe use.\n\nMethods: We retrospectively collected data from ten ophthalmology departments in Israel. The number of intravitreal anti-VEGF injections administered in years 2022 and 2023 was recorded. Endophthalmitis rates in 2022 (vial use) and in 2023 (prefilled syringe use) were compared. Clinical details of endophthalmitis cases were reviewed.\n\nResults : In 2022, out of 119,904 intravitreal injections, 31,991 (27%) were aflibercept injections prepared from vials. In 2023, out of 128,306 intravitreal injections, 35,589 (28%) were aflibercept injections from prefilled syringes. Endophthalmitis rates were similar between vial preparation (1:1991) and prefilled syringe (1:2372) (p = 0.63). Notably, aflibercept injections exhibited significantly higher endophthalmitis rates compared to bevacizumab and ranibizumab combined, in both years (1:1999 vs. 1:5494 in 2022, and 1:2373 vs. 1:7132 in 2023, respectively; p < 0.01 for both).\n\nConclusion: Despite the transit to prefilled aflibercept syringes, endophthalmitis rates following aflibercept injection did not decrease. Post-injection endophthalmitis rates were significantly higher with aflibercept compared to bevacizumab and ranibizumab, with both vial and prefilled syringe.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Ophthalmology, Sheba Medical Center, Faculty of Medical and Health Sciences, Goldschleger Eye Institute, Tel Aviv University, Tel Aviv, Israel",
    "Gray Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv, Israel",
    "Division of Ophthalmology, Tel Aviv Medical Center, Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv, Israel",
    "Department of Ophthalmology, Shaare Zedek Medical Center, Faculty of medicine, Hebrew University of Jerusalem, Jerusalem, Israel",
    "Department of Ophthalmology, Faculty of Medical and Health Sciences, Meir Medical Center, Tel Aviv University, Tel Aviv, Israel",
    "Ophthalmology Institute, Assuta Medical Centers, Tel Aviv, Israel",
    "Faculty of Health Sciences, Ben-Gurion University of the Negev, Beersheba, Israel",
    "Department of Ophthalmology, Rambam Health Care Campus, Haifa, Israel",
    "Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel",
    "Wolfson Medical Center, Holon, Israel",
    "Department of Ophthalmology, Assaf-Harofeh Medical Center, Zerifin, Israel, Affiliated to the Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv, Israel",
    "Department of Ophthalmology, Faculty of Health Sciences, Barzilai Medical Center, Ben-Gurion University, Ashkelon, Be’er Sheba, Israel",
    "Department of Ophthalmology, Hadassah Medical Center, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 16,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Daniel David"
    },
    {
      "affs": [
        2,
        1
      ],
      "name": "Dinah Zur"
    },
    {
      "affs": [
        2,
        1
      ],
      "name": "Amit Biran"
    },
    {
      "affs": [
        3
      ],
      "name": "Sharon Braudo"
    },
    {
      "affs": [
        3
      ],
      "name": "Koby Brosh"
    },
    {
      "affs": [
        4,
        1
      ],
      "name": "Elad Moisseiev"
    },
    {
      "affs": [
        5,
        6
      ],
      "name": "Shiri Shulman"
    },
    {
      "affs": [
        7,
        8
      ],
      "name": "Yoreh Barak"
    },
    {
      "affs": [
        9,
        1
      ],
      "name": "Rita Ehrlich"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Shalev Fried"
    },
    {
      "affs": [
        10,
        1
      ],
      "name": "Alon Peled"
    },
    {
      "affs": [
        11
      ],
      "name": "David Hauser"
    },
    {
      "affs": [
        12
      ],
      "name": "Tareq Jaouni"
    },
    {
      "affs": [
        10,
        1
      ],
      "name": "Eran Pras"
    },
    {
      "affs": [
        11
      ],
      "name": "Hagay Hayat"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Gabriel Katz"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/9cr99fdp2mehd.bib",
  "cited_by": 1,
  "doi": "10.1007/s00417-026-07285-2",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13736327/",
  "id": "9cr99fdp2mehd",
  "issns": [
    "0721-832X",
    "1435-702X"
  ],
  "landing_url": "https://doi.org/10.1007/s00417-026-07285-2",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Research"
    ],
    [
      "openalex",
      "2731|Ocular Infections and Treatments"
    ]
  ],
  "openalex": "W7162798784",
  "pdf_url": "https://link.springer.com/content/pdf/10.1007/s00417-026-07285-2.pdf",
  "pmcid": "PMC13736327",
  "pmid": "42213133",
  "published": "2026-05-29",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/9cr99fdp2mehd.ris",
  "sources": [
    {
      "first_seen": "2026-11-09T12:21:48Z",
      "native_id": "PMC13736327",
      "source": "pmc",
      "url": "https://doi.org/10.1007/s00417-026-07285-2"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2731|Ocular Infections and Treatments",
      "subfield": "general"
    }
  ],
  "title": "Endophthalmitis rates following intravitreal injection of aflibercept using a prefilled syringe – a multicenter study",
  "title_text": "Endophthalmitis rates following intravitreal injection of aflibercept using a prefilled syringe – a multicenter study",
  "type": "peer-reviewed",
  "updated_at": "2026-11-09T12:21:48Z",
  "url": "https://research.draconitic.com/paper/9cr99fdp2mehd",
  "venue": "Graefe's Archive for Clinical and Experimental Ophthalmology",
  "versions": []
}