{
  "abstract": "A 55-year-old man with lower abdominal pain and diarrhea was referred to our hospital. Computed tomography (CT) revealed a hypovascular liver tumor, lymph node/bone metastases, and peritoneal dissemination. Based on a histological analysis of lymph node metastasis, he was diagnosed with combined hepatocellular-cholangiocarcinoma (cHCC-CCA) and received durvalumab plus gemcitabine and cisplatin (Dur/GC). After treatment, the patient developed grade 2 diarrhea and grade 3 thrombocytopenia. CT after one course of Dur/GC demonstrated tumor shrinkage and expanded peritoneal dissemination, suggesting the need for further studies on the efficacy and safety of this therapy for unresectable cHCC-CCA.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 15,
  "authors": [
    {
      "name": "Daisuke Kobayashi"
    },
    {
      "name": "Manabu Hayashi"
    },
    {
      "name": "Yosuke Takahata"
    },
    {
      "name": "Masashi Fujita"
    },
    {
      "name": "Naoto Abe"
    },
    {
      "name": "Tatsuro Sugaya"
    },
    {
      "name": "Kazuki Akaike"
    },
    {
      "name": "Kentaro Sato"
    },
    {
      "name": "Hiroshi Shimizu"
    },
    {
      "name": "Hiroyuki Asama"
    },
    {
      "name": "Kazumichi Abe"
    },
    {
      "name": "Yasuyuki Kobayashi"
    },
    {
      "name": "Yuko Hashimoto"
    },
    {
      "name": "Takuto Hikichi"
    },
    {
      "name": "Hiromasa Ohira"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/9ctby2am2sxqj.bib",
  "cited_by": 0,
  "doi": "10.2169/internalmedicine.6512-25",
  "fulltext_url": "https://www.jstage.jst.go.jp/article/internalmedicine/65/20/65_6512-25/_article",
  "id": "9ctby2am2sxqj",
  "issns": [
    "1349-7235",
    "0918-2918"
  ],
  "landing_url": "https://www.jstage.jst.go.jp/article/internalmedicine/65/20/65_6512-25/_article",
  "language": null,
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "jstage-journal",
      "medicine/general"
    ],
    [
      "openalex",
      "2721|Hepatocellular Carcinoma Treatment and Prognosis"
    ]
  ],
  "openalex": "W7136127339",
  "pdf_url": "https://www.jstage.jst.go.jp/article/internalmedicine/65/20/65_6512-25/_pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-15",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/9ctby2am2sxqj.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:31Z",
      "native_id": "10.2169/internalmedicine.6512-25",
      "source": "jstage",
      "url": "https://www.jstage.jst.go.jp/article/internalmedicine/65/20/65_6512-25/_article"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2721|Hepatocellular Carcinoma Treatment and Prognosis",
      "subfield": "general"
    }
  ],
  "title": "Combined Hepatocellular-cholangiocarcinoma Patient Treated with Durvalumab Plus Gemcitabine and Cisplatin",
  "title_text": "Combined Hepatocellular-cholangiocarcinoma Patient Treated with Durvalumab Plus Gemcitabine and Cisplatin",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:31Z",
  "url": "https://research.draconitic.com/paper/9ctby2am2sxqj",
  "venue": "Internal Medicine",
  "versions": []
}