{ "abstract": "Atopic dermatitisis a chronic skin disease that requires long-term monitoring, which can be assessed using Atopic Dermatitis Control Tool (ADCT). Achieving minimal disease activity is also becoming an important issue in the treatment of atopic dermatitis. We aimed to identify which minimal disease sctivity patient-reported outcomes most closely reflect ADCT-defined disease control. We conducted a multicentric, observational retrospective study in patients with moderate-to-severe atopic dermatitis treated with upadacitinib. Outcome measures were collected at different time points (Week 0, 4, 16, 32, 52). Longitudinal changes were assessed with the paired Wilcoxon signedrank test; cross-sectional ADCT–patient-reported outcomes associations were evaluated at each visit using Spearman rank correlation coefficient (ρ). A total of 212 were included. All outcomes improved significantly from Week 4 onwards (all p<0.001). An ADCT score<7 was reached by 84.6% of evaluable patients at Week 4 and 90.1% at Week 52. At each timepoint, ADCT showed the strongest correlation with POEM (ρ range: 0.64–0.64) compared to other minimal disease sctivity patient-reported outcomes. These findings indicate that, among the minimal disease sctivity patient-reported outcomes, POEM most closely reflects the patient’s perception of atopic dermatitis control assessed by ADCT. Larger prospective studies are warranted to confirm these preliminary observations.", "abstract_shown": true, "affiliations": [ "Dermatological Department, Istituto Dermopatico dell'Immacolata, IDI-IRCCS, Dermatological Research Hospital, Rome, Italy", "Section of Dermatology, Department of Medical Sciences, University of Ferrara, Ferrara, Italy", "Bioinformatics Unit, Istituto Dermopatico dell'Immacolata, IDI-IRCCS, Dermatological Research Hospital, Rome, Italy", "Dermatologic Clinic, Sapienza University of Rome, Rome, Italy", "Dermatology Unit, Istituto Nazionale di Riposo e Cura per Anziani, Istituto Nazionale di Ricovero e Cura degli Anziani (INRCA)-IRCCS Hospital, Ancona, Italy.x", "Dermatologia, Dipartimento Universitario di Medicina e Chirurgia Traslazionale, Università Cattolica del Sacro Cuore, Rome, Italy; U.O.C. Dermatologia, Dipartimento di Scienze Mediche e Chirurgiche, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy", "Department of Dermatology, University of Pisa, Pisa, Italy; Health Science Interdisciplinary Center, Sant'Anna School of Advanced Studies, Pisa, Italy", "Dermatology Unit, Department of Medical, Surgical and Neurological Sciences, University of Siena, Siena, Italy", "Dermatology Section, Department of Medicine and Surgery, University of Perugia, Perugia, Italy", "Clinic of Dermatology, Department of Medicine and Aging Sciences, University G. D'Annunzio, Chieti, Italy", "Dermatology Unit, AOU of Cagliari, Department Medical Sciences and Public Health, University of Cagliari, Cagliari, Italy", "Department of Systems Medicine, University of Rome “Tor Vergata”, Rome, Italy", "Dermatology Unit, Istituto Nazionale di Riposo e Cura per Anziani, Istituto Nazionale di Ricovero e Cura degli Anziani (INRCA)-IRCCS Hospital, Ancona, Italy.", "U.O.C. Dermatologia, Dipartimento di Scienze Mediche e Chirurgiche, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy", "Health Science Interdisciplinary Center, Sant'Anna School of Advanced Studies, Pisa, Italy", "Department of Systems Medicine, University of Rome “Tor Vergata”, Rome, Italy; Dermatology Unit, Azienda Ospedaliera Universitaria Policlinico Tor Vergata, Rome, Italy" ], "article_type": "research article", "arxiv": null, "author_total": 23, "authors": [ { "affs": [ 0 ], "name": "Filomena Russo", "orcid": "0000-0003-2780-7720" }, { "affs": [ 1 ], "name": "Natale Schettini", "orcid": "0000-0002-6693-766X" }, { "affs": [ 2 ], "name": "Giovanni Scaglione", "orcid": "0000-0001-5622-7843" }, { "affs": [ 3 ], "name": "Ester Del Duca" }, { "affs": [ 4 ], "name": "Tommaso Bianchelli" }, { "affs": [ 5 ], "name": "Niccolò Gori" }, { "affs": [ 6 ], "name": "Flavia Margiotta" }, { "affs": [ 7 ], "name": "Laura Calabrese" }, { "affs": [ 8 ], "name": "Elettra Antonelli" }, { "affs": [ 9 ], "name": "Federica Giuliani" }, { "affs": [ 10 ], "name": "Viviana Piras" }, { "affs": [ 0 ], "name": "Sabatino Pallotta" }, { "affs": [ 1 ], "name": "Chiara Bocchi" }, { "affs": [ 11 ], "name": "Edoardo Mortato" }, { "affs": [ 3 ], "name": "Camilla Chello" }, { "affs": [ 12 ], "name": "Helena Gioacchini" }, { "affs": [ 13 ], "name": "Maria Cannizzaro" }, { "affs": [ 14 ], "name": "Marco Romanelli" }, { "affs": [ 7 ], "name": "Laura Lazzeri" }, { "affs": [ 8 ], "name": "Katharina Hansel" }, { "affs": [ 9 ], "name": "Paolo Amerio" }, { "affs": [ 10 ], "name": "Laura Atzori" }, { "affs": [ 15 ], "name": "Marco Galluzzo" } ], "bibtex": "https://research.draconitic.com/paper/9cthy5p6teqhk.bib", "cited_by": 0, "doi": "10.2340/actadv.v106.adv-2026-0815", "fulltext_url": "https://medicaljournalssweden.se/actadv/article/view/47150", "id": "9cthy5p6teqhk", "issns": [ "0001-5555", "1651-2057" ], "landing_url": "https://doi.org/10.2340/actadv.v106.adv-2026-0815", "language": "en", "licence": "CC-BY-NC", "licence_label": "CC BY-NC", "licence_source": "article", "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/", "metadata_licence": null, "native_subjects": [ [ "heading", "Atopy, Allergy and Eczema" ], [ "heading", "Original Report" ], [ "lcc", "RL1-803" ] ], "openalex": null, "pdf_url": "https://europepmc.org/articles/PMC13725904?pdf=render", "pmcid": "PMC13725904", "pmid": "42969560", "published": "2026-11-02", "publisher": "Medical Journals Sweden", "ris": "https://research.draconitic.com/paper/9cthy5p6teqhk.ris", "sources": [ { "first_seen": "2026-11-02T14:21:15Z", "native_id": "2021d350c34e45e7a96308dd0e0f7e11", "source": "doaj", "url": "https://doi.org/10.2340/actadv.v106.adv-2026-0815" }, { "first_seen": "2026-11-03T15:20:53Z", "native_id": "MED:42969560", "source": "europepmc", "url": "https://europepmc.org/article/MED/42969560" }, { "first_seen": "2026-11-05T12:22:21Z", "native_id": "PMC13725904", "source": "pmc", "url": "https://doi.org/10.2340/actadv.v106.adv-2026-0815" } ], "subjects": [ { "field": "medicine", "origin": "lcc:RL1-803", "subfield": "general" } ], "title": "Explorative Correlation of Atopic Dermatitis Control Tool with Minimal Disease Activity Patient-reported Outcomes in Patients Treated with Upadacitinib: A Retrospective Real-world Study", "title_text": "Explorative Correlation of Atopic Dermatitis Control Tool with Minimal Disease Activity Patient-reported Outcomes in Patients Treated with Upadacitinib: A Retrospective Real-world Study", "type": "peer-reviewed", "updated_at": "2026-11-06T12:21:59Z", "url": "https://research.draconitic.com/paper/9cthy5p6teqhk", "venue": "Acta Dermato-Venereologica", "versions": [] }