{
  "abstract": "Childhood trauma affects neurodevelopment and lifelong risk for posttraumatic stress disorder (PTSD) and alcohol use disorder (AUD). Changes in brain structures and function are observed in young carriers of APOEε4, the genetic factor most associated with Alzheimer's disease. Longitudinal studies of APOEε4, childhood trauma, and neural connectivity in adolescence have not been explored. We studied 837 trauma‐exposed participants (53% female) from the Collaborative Study on the Genetics of Alcoholism prospective sample, using latent growth curve models to assess associations of childhood trauma and APOEε4 on repeated measures of frontal alpha EEG coherence (EEGc) throughout adolescence and young adulthood. Young adult AUD and PTSD symptoms were also examined. Results indicate childhood sexual assaultive trauma (CSAT) and APOEε4 are linked to neural connectivity, with effects differing by brain region and direction. CSAT was associated with a higher EEGc baseline but less growth in three EEGc pairs, while APOEε4 associated with lower left frontocentral (LFC) EEGc baseline and higher slope. EEGc patterns and symptoms of PTSD and AUD were robustly associated. A significant interaction between CSAT‐by‐APOEε4 interaction also emerged, such that among APOEε4 carriers, childhood sexual assaultive trauma was associated with higher baseline PFI and diminished growth in PFI and LFC EEGc. No significant direct links between APOEε4 and PTSD or AUD were observed. Findings highlight how EEGc may help explain connections between genetics, trauma, and psychopathology, guiding at‐risk group identification and informing prevention strategies.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Psychiatry and Behavioral Sciences State University of New York Downstate Health Sciences University Brooklyn New York USA",
    "VA New York Harbor Healthcare System Brooklyn New York USA",
    "Department of Psychiatry Rutgers University, Robert Wood Johnson Medical School Piscataway New Jersey USA",
    "Department of Genetics and Genomic Sciences Icahn School of Medicine at Mount Sinai New York New York USA",
    "Icahn School of Medicine at Mount Sinai, Ronald M. Loeb Center for Alzheimer's Disease New York New York USA",
    "Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics Virginia Commonwealth University Richmond Virginia USA"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 14,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Zoe E. Neale",
      "orcid": "0000-0001-6440-2445"
    },
    {
      "affs": [
        2
      ],
      "name": "Megan E. Cooke"
    },
    {
      "affs": [
        0
      ],
      "name": "Jasmine Cárcamo",
      "orcid": "0009-0004-4067-1359"
    },
    {
      "affs": [
        0
      ],
      "name": "Maissa Trabilsy"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Peter B. Barr",
      "orcid": "0000-0001-9321-657X"
    },
    {
      "affs": [
        0
      ],
      "name": "Chris Chatzinakos"
    },
    {
      "affs": [
        0
      ],
      "name": "Rachel Furhang"
    },
    {
      "affs": [
        0
      ],
      "name": "David B. Chorlian"
    },
    {
      "affs": [
        0
      ],
      "name": "Weipeng Kuang",
      "orcid": "0009-0008-2622-2556"
    },
    {
      "affs": [
        0
      ],
      "name": "Gayathri Pandey",
      "orcid": "0000-0003-0889-3117"
    },
    {
      "affs": [
        3,
        4
      ],
      "name": "Alison M. Goate",
      "orcid": "0000-0002-0576-2472"
    },
    {
      "affs": [
        0
      ],
      "name": "Bernice Porjesz"
    },
    {
      "affs": [
        5
      ],
      "name": "Ananda B. Amstadter",
      "orcid": "0000-0001-6285-9943"
    },
    {
      "affs": [
        0
      ],
      "name": "Jacquelyn L. Meyers"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/9cwdh7fvfbjba.bib",
  "cited_by": 0,
  "doi": "10.1111/gbb.70068",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13736786/",
  "id": "9cwdh7fvfbjba",
  "issns": [
    "1601-1848",
    "1601-183X"
  ],
  "landing_url": "https://doi.org/10.1111/gbb.70068",
  "language": "en",
  "licence": "CC-BY-NC-4.0",
  "licence_label": "CC BY-NC 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Original Article"
    ],
    [
      "openalex",
      "3203|Child Abuse and Trauma"
    ]
  ],
  "openalex": "W4410106853",
  "pdf_url": "https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/gbb.70068",
  "pmcid": "PMC13736786",
  "pmid": "42985910",
  "published": "2026-11-05",
  "publisher": "Wiley",
  "ris": "https://research.draconitic.com/paper/9cwdh7fvfbjba.ris",
  "sources": [
    {
      "first_seen": "2026-11-09T12:22:10Z",
      "native_id": "PMC13736786",
      "source": "pmc",
      "url": "https://doi.org/10.1111/gbb.70068"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:3203|Child Abuse and Trauma",
      "subfield": "psychiatry"
    }
  ],
  "title": "Childhood Trauma and APOEε4 Are Associated With Patterns of Developmental Frontal Alpha Connectivity, Posttraumatic Stress, and Alcohol‐Related Outcomes",
  "title_text": "Childhood Trauma and APOEε4 Are Associated With Patterns of Developmental Frontal Alpha Connectivity, Posttraumatic Stress, and Alcohol‐Related Outcomes",
  "type": "peer-reviewed",
  "updated_at": "2026-11-09T12:22:10Z",
  "url": "https://research.draconitic.com/paper/9cwdh7fvfbjba",
  "venue": "Genes, Brain, and Behavior",
  "versions": []
}