{
  "abstract": "While studies have demonstrated improved clinical outcomes with the use of controlled hypothermic storage (CHS) devices in isolated heart transplantation, it has not been evaluated in combined heart transplantation. In this small retrospective study (n=17), we evaluate clinical outcomes after combined heart-liver and heart-kidney transplantation in recipients of donor hearts preserved with conventional ice cold storage (ICS, n=10) versus CHS (n=7). The study found severe early graft dysfunction (EGD) occurred more frequently in the ICS cohort when compared to the CHS cohort (70% vs 0%, respectively). In addition, the CHS cohort had shorter median intensive care unit length of stay (7 days compared to 15.5 days, respectively) as well as fewer post-transplant complications, including sepsis (60% in ICS and 28.6% in CHS), pneumonia (40% in ICS and 14.3% in CHS), stroke (30% in ICS and 0% in CHS), and acute kidney injury requiring dialysis (60% in ICS and 28.6% in CHS). These preliminary findings suggest CHS may improve outcomes in combined heart transplantation.",
  "abstract_shown": true,
  "affiliations": [
    "Adult Cardiac Surgery and Transplantation, Marie Lannelongue Hospital, Groupe Hospitalier Paris Saint Joseph, Le Plessis Robinson, France.",
    "Adult Cardiac Surgery and Transplantation, Hôpital Européen Georges-Pompidou, Paris, France.",
    "Department of Adult Cardiac Disease, Marie Lannelongue Hospital, Groupe Hospitalier Paris Saint Joseph, Le Plessis Robinson, France.",
    "Hepatobiliary Centre, Paul-Brousse Hospital, AP-HP, Paris-Saclay University, INSERM U1193, Villejuif, France.",
    "Nephrology-Dialysis-Transplantation, Bicêtre Hospital, AP-HP, LeKremlin-Bicêtre, France; INSERM U1184, Le Kremlin-Bicêtre, France.",
    "Adult Intensive Care Unit, Marie Lannelongue Hospital, Groupe Hospitalier Paris Saint Joseph, Le Plessis Robinson, France.",
    "Congenital Cardiac Surgery and Transplantation, Marie Lannelongue Hospital, Groupe Hospitalier Paris Saint Joseph, Le Plessis Robinson, France.",
    "Inserm UMR_S1358, Medical School, University of Paris Saclay, Le Kremlin Bicêtre, France."
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 12,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Salem T Argaw"
    },
    {
      "affs": [
        1
      ],
      "name": "Lorenzo Lora Ronco"
    },
    {
      "affs": [
        0
      ],
      "name": "Anouk Frering"
    },
    {
      "affs": [
        2
      ],
      "name": "Martin Kloeckner"
    },
    {
      "affs": [
        1
      ],
      "name": "Guillaume Coutance"
    },
    {
      "affs": [
        3
      ],
      "name": "Audrey Coilly"
    },
    {
      "affs": [
        3
      ],
      "name": "Eric Vibert"
    },
    {
      "affs": [
        4
      ],
      "name": "Renaud Snanoudj"
    },
    {
      "affs": [
        5
      ],
      "name": "Thibaut Genty"
    },
    {
      "affs": [
        1
      ],
      "name": "Paul Achouh"
    },
    {
      "affs": [
        6
      ],
      "name": "Emre Belli"
    },
    {
      "affs": [
        0,
        2,
        7
      ],
      "name": "Julien Guihaire"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/9cy1mffdmavsm.bib",
  "cited_by": 0,
  "doi": "10.1016/j.jhlto.2026.100707",
  "fulltext_url": "https://europepmc.org/articles/PMC13743936",
  "id": "9cy1mffdmavsm",
  "issns": [
    "2950-1334"
  ],
  "landing_url": "https://europepmc.org/article/MED/42999535",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2746|Transplantation: Methods and Outcomes"
    ]
  ],
  "openalex": "W7221754078",
  "pdf_url": "https://europepmc.org/articles/PMC13743936?pdf=render",
  "pmcid": "PMC13743936",
  "pmid": "42999535",
  "published": "2026-10-14",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/9cy1mffdmavsm.ris",
  "sources": [
    {
      "first_seen": "2026-11-09T15:20:41Z",
      "native_id": "MED:42999535",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42999535"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2746|Transplantation: Methods and Outcomes",
      "subfield": "surgery"
    }
  ],
  "title": "Preliminary experience with controlled hypothermic storage of donor heart in combined heart transplantation.",
  "title_text": "Preliminary experience with controlled hypothermic storage of donor heart in combined heart transplantation.",
  "type": "peer-reviewed",
  "updated_at": "2026-11-09T15:20:41Z",
  "url": "https://research.draconitic.com/paper/9cy1mffdmavsm",
  "venue": "JHLT open",
  "versions": []
}